A5021251366- Urinary Bladder and Prostate Research
- Lipid Membrane Structure and Behavior
- Cellular transport and secretion
- Cancer Genomics and Diagnostics
- Neuroscience of respiration and sleep
- Head and Neck Cancer Studies
- Hippo pathway signaling and YAP/TAZ
- Genetic factors in colorectal cancer
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Melanoma and MAPK Pathways
- Pelvic floor disorders treatments
- Nerve injury and regeneration
- Fibroblast Growth Factor Research
- Urological Disorders and Treatments
- Cancer-related Molecular Pathways
- Retinal Development and Disorders
- Supramolecular Self-Assembly in Materials
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Treatments and Mutations
- HER2/EGFR in Cancer Research
- Advances in Cucurbitaceae Research
- Ear and Head Tumors
Augusta University Health
2024-2025
Augusta University
2025
Khoo Teck Puat Hospital
2024
National University Hospital
2011-2024
Sibu Hospital
2024
Chinese University of Hong Kong
1989-2018
University of Hong Kong
2006-2014
UPMC Hillman Cancer Center
2014
University of Pittsburgh
1999-2013
University of Michigan
1999
We observed that a number of patients with severe acute respiratory syndrome (SARS) developed affective psychosis during the phase their illness. reviewed all SARS-related psychiatric consultations in Hong Kong and investigated risk factors for among SARS matched case-control study. Patients received higher total doses steroids had rates family history The findings present study suggest steroid toxicity, personal vulnerability, and, probably, psychosocial stressors jointly contributed to...
Neuropeptides are slowly released from a limited pool of secretory vesicles. Despite decades research, the composition this has remained unknown. Endocrine cell studies support hypothesis that population docked vesicles supports first minutes hormone release. However, it been proposed mobile cytoplasmic dominate releasable neuropeptide pool. Here, to determine cellular basis pool, single green fluorescent protein-labeled were visualized in neuronal growth cones with use an inducible...
Objective: RAC1 aberrations in head and neck squamous cell carcinoma (HNSCC) remain clinically inactionable today. Methods: Here, we investigated the clinical significance potential druggability of genomic HNSCC. Results: Notably, HPV(−)HNSCC patients bearing unique HNSCC-prevalent RAC1-A159V hotspot mutation, P29S G-box domain mutations, copy number increases all displayed dismal overall survival (TCGA-HNSCC). demonstrated that five HNSCC patient-relevant tested (A159V K116N, G15S, N39S)...
Abstract We have developed a flash radiometry technique for the determination of thermal diffusivity polymer films that consists flashing laser pulse on front surface sample and monitoring radiation from rear as function time using an infrared detector. This method is applicable to thickness 14–250 μm in wide temperature range between 150 500 K. performed measurements four polymers, including polycarbonate, polyimide, polyvinylidene fluoride, polyethylene terephthalate. The dependence...
Nasopharyngeal carcinoma (NPC) is an Asian-prevalent head and neck cancer with high invasiveness. Although several important risk factors for NPC development have been identified, there currently no preventive strategy NPC, even in endemic regions. Signal transducer activator of transcription 3 (STAT3) has implicated carcinogenesis, which may serve as a potential target prevention. Here, we examined the chemopreventive Cucurbitacin I, natural-occurring selective inhibitor JAK/STAT3, models....
No AccessJournal of UrologyInvestigative Urology1 Oct 2008Sonic Hedgehog Mediator Gli2 Regulates Bladder Mesenchymal Patterningis accompanied byConserved Molecular Paradigms Pattern Smooth Muscle in Urogenital Developmentis companion ofThe Relevance Urodynamic Studies for Urge Syndrome and Dysfunctional Voiding: A Multicenter Controlled Trial Children Wei Cheng, Chung-Kwong Yeung, Yuen-Keng Ng, Jian-Rong Zhang, Chi-Chung Hui, Peter C.W. Kim ChengWei Cheng Division Paediatric Surgery,...
It has been speculated that neurosecretion can be enhanced by increasing the motion, and hence, availability of cytoplasmic secretory vesicles. However, facilitator‐induced physical mobilization vesicles not observed directly in living cells, recent experimental results call this hypothesis into question. Here, high resolution green fluorescent protein (GFP)‐based measurements nerve growth factor‐differentiated PC12 cells are used to test whether altering dense core vesicle (DCV) motion...
In vitro preparations of whole urinary bladders neonatal rats exhibit prominent myogenic spontaneous contractions, the amplitude and frequency which can be increased by muscarinic agonists. The receptor subtype responsible for this facilitation was examined in present experiments. Basal contractions from 1- to 2-wk-old Sprague-Dawley were not affected M2 or M3 antagonists. However, administration 0.5 microM physostigmine, an anticholinesterase agent that increases levels endogenous...
Spontaneous bladder contractions (SBCs) in the neonatal rat urinary change from a high-amplitude, low-frequency pattern to low-amplitude, high-frequency during first 6 wk of life. Understanding mechanism this developmental may provide insights into causes overactivity adults. In vitro whole preparations Sprague-Dawley rats were used study modulation SBCs by calcium-activated potassium channels (K(Ca)) and electrical field stimulation 3 days 3-day-old bladders unmasked treatment with...
The BRAF inhibitor vemurafenib is currently used for treating patients with V600E mutant melanoma. However, the responses to are generally partial and of relatively short duration. Recent evidence suggests that activation epidermal growth factor receptor (EGFR)/erbB signaling pathway may be responsible development resistance in melanoma patients. In this study, we characterized erbB family receptors ligands cell lines examined whether targeting both provided enhanced antitumor activity...
Four and a Half LIM protein 2 (FHL2) is domain only that able to form various complexes regulate gene transcription. Recent findings showed FHL2 potential tumor suppressor was down-regulated in hepatocellular carcinoma (HCC). Moreover, can bind activate the TP53 promoter hepatic cells. In this study, activity of two promoters FHL2, 1a 1b, were determined human embryonic kidney cell line HEK293 activation these by p53 investigated. Our results 1b has higher than HEK 293 cells but more...
The thermal diffusivity D of three metallic glasses Fe80B20, Fe40Ni40P14B6, and Fe32Ni36Cr14P12B6 has been measured from 160 to 500 K by the laser-flash radiometry method conductivity calculated these data. accuracy is 6% 8%, respectively. electronic contribution (Ke) conductivity, evaluated using Wiedemann–Franz law, increases almost linearly with increasing temperature. phonon Kph follows temperature dependence exhibited all amorphous dielectrics, i.e., roughly proportional specific heat,...
The present investigation was focused on the ultrastructural changes in neurons and glial cells retina of rats with experimentally-induced glaucoma. An experimental glaucoma model created by limbal-derived vein cauterization. Animals were sacrificed at 1, 3 weeks months post-operation. Retinae dissected processed for electron microscopy. Neuronal degeneration observed all different layers both 1 Some degenerating found ganglion cell layer (GCL), inner nuclear (INL) outer (ONL). And dying...
PC12 cells, like endocrine chromaffin undergo neuronal-like differentiation in response to nerve growth factor (NGF). Here we report that this phenotype conversion produces major changes release of a green fluorescent protein-tagged neuropeptide–hormone. First, the spatial distribution releasable pool is altered; peptide from untreated cells supported predominantly by membrane-proximal vesicles, whereas diffuse at ends processes used NGF-treated cells. Second, time course evoked photolysis...
The putative tumor suppressor Mst1, when cleaved to its 36kDa form, amplifies apoptotic signals. We found that Mst1 was predominantly expressed in full-length form 76% (17/25 cases) of hepatocellular carcinoma (HCC) tumors. cleavage basically absent HCC cells. Ectopic expression increased the growth cells by 55-80% within 3days after transfection. Expression exogenous NORE1B, a commonly lost tumors (~56% our cohort), sufficient suppress promotion Mst1. Hence, exhibits promoting activity upon...
Abstract Dysregulated activation of the epidermal growth factor receptor (ErbB) family (EGFR, ErBB2, ErbB3, and ErbB4) is involved in promoting cellular human melanoma. EGFR, ErbB4 are promising targets malignant melanoma for new molecular drug development. However, biology ErbB signaling pathways indicates that functional redundancy heterodimerization among members can greatly compromise therapeutic efficacy single targeting tyrosine kinase inhibitors (TKIs). In fact, Phase II clinical...