A5100651423- Fermentation and Sensory Analysis
- Plant-Microbe Interactions and Immunity
- Plant Stress Responses and Tolerance
- Gut microbiota and health
- Plant Molecular Biology Research
- Clostridium difficile and Clostridium perfringens research
- Plant tissue culture and regeneration
- Food Quality and Safety Studies
- Microbial Metabolism and Applications
- Tea Polyphenols and Effects
- Plant Pathogenic Bacteria Studies
- Plant Gene Expression Analysis
- Legume Nitrogen Fixing Symbiosis
- Pediatric Hepatobiliary Diseases and Treatments
- Plant responses to water stress
- Hedgehog Signaling Pathway Studies
- Meat and Animal Product Quality
- Phytochemicals and Antioxidant Activities
- Wastewater Treatment and Nitrogen Removal
- Plant biochemistry and biosynthesis
- Intestinal Malrotation and Obstruction Disorders
- Plant Virus Research Studies
- Gastrointestinal motility and disorders
- Probiotics and Fermented Foods
- Microbial Metabolites in Food Biotechnology
Chengdu Women's and Children's Central Hospital
2024-2025
University of Electronic Science and Technology of China
2024-2025
Jilin Agricultural University
2024-2025
Changchun University of Technology
2025
Xinjiang Production and Construction Corps
2025
Tarim University
2025
Yunnan University
2025
Shaanxi University of Science and Technology
2022-2024
Huazhong Agricultural University
2012-2024
Hohai University
2023-2024
Summary Fusarium head blight ( FHB ) and seedling FSB of wheat, caused by pathogens, are devastating diseases worldwide. We report the expression RNA interference i) sequences derived from an essential F usarium graminearum Fg virulence gene, chitin synthase Chs 3b, as a method to enhance resistance wheat plants fungal pathogens. Deletion Chs3b was lethal ; disruption other gene family members generated knockout mutants with diverse impacts on . Comparative analyses revealed that among...
Innate immunity against pathogen infection is an evolutionarily conserved process among multicellular organisms. Arabidopsis SNC1 encodes a Resistance protein that combines attributes of multiple mammalian pattern recognition receptors. Utilizing snc1 as autoimmune model, we identified discrete complex containing at least three members--MOS4 (Modifier Of snc1, 4), AtCDC5, and PRL1 (Pleiotropic Regulatory Locus 1)--that are all essential for plant innate immunity. AtCDC5 has DNA-binding...
Abstract Necrotizing enterocolitis (NEC) is a severe, currently untreatable intestinal disease that predominantly affects preterm infants and driven by poorly characterized inflammatory pathways. Here, human murine NEC intestines exhibit an unexpected predominance of type 3/T H 17 polarization. In NEC, pro-inflammatory 3 NKp46 − RORγt + Tbet innate lymphoid cells (ILC3) are 5-fold increased, whereas ILC1 protective ILC3 obliterated. Both species dysregulation TLR repertoires, with TLR4 TLR8...
Wheat-originated microbes play an important role in shaping the quality of high-temperature Daqu which is commonly used as a starter for producing sauce-flavor Baijiu . However, shifts microbiota from raw material to fresh and then mature remain unclear. Hence, present study, inner outer were collected explore correlation between metabolites well source Results indicated that activities amylase protease varied significantly while both parts became similar after maturation. The predominant...
The microbial composition and volatile components of fermented grains (FG) pit mud (PM) are crucial for the quality flavor compound-flavor baijiu (CFB). physicochemical indices, culturable microorganisms, communities, FG PM were analyzed correlated in our research. Considering PM, amplicon sequencing was used to analyze community detected by headspace solid-phase microextraction-gas chromatography-mass spectrometry (HS-SPME). For FG, redundancy analysis correlation perfume Circos clarify...
Assessing the geological suitability of urban underground space development is crucial for mitigating risks. Traditional 2D evaluation methods fail to capture complex vertical variations in space, hindering precise planning. This paper presents an innovative 3D-CWC framework, combining a weighted cloud model with three-dimensional modeling, address complexity and uncertainty assessments. The study area, located northern part Kunming’s Second Ring Road, divided into 22 million 25 m × 1 3D...
CaWRKY40 is known to act as a positive regulator in the response of pepper (Capsicum annuum) Ralstonia solanacearum inoculation (RSI) or high temperature-high humidity (HTHH), but underlying mechanism remains elusive. Herein, we report that CabZIP63, bZIP family member, participates this process by regulating expression CaWRKY40. CabZIP63 was found localize nuclei, be up-regulated RSI HTHH, bind promoters both CabZIP63(pCabZIP63) and CaWRKY40(pCaWRKY40), activate pCabZIP63- pCaWRKY40-driven...
In clinical practice, fecal microbiota transplantation (FMT) has been used to treat inflammatory bowel disease (IBD), and shown certain effects. However, the selection of FMT donors mechanism underlying effect intervention in IBD require further exploration. this study, dextran sodium sulfate (DSS)-induced colitis mice were determine differences protection symptoms, inflammation, intestinal barrier, by from two donors. Intriguingly, pre-administration healthy bacterial fluid significantly...
The bladder, the largest smooth-muscle organ in human body, is responsible for urine storage and micturition. P63, a homolog of p53 tumor-suppressor gene, essential development all stratified epithelia, including bladder urothelium. N-terminal truncated isoform p63, DeltaNp63, known to have anti-apoptotic characteristics. We established that DeltaNp63 not only predominant expressed throughout but also preferentially ventral urothelium during early development. observed host defects p63-/-...
Abstract Transient receptor potential ankyrin 1 (TRPA1) plays an important role in different cardiovascular diseases. However, the of TRPA1 dilated cardiomyopathy (DCM) remains unclear. Here, we aimed to investigate DCM induced by doxorubicin (DOX) and explore its possible mechanisms. GEO data were used expression patients. DOX (2.5 mg/kg/week, 6 weeks, i.p.) was induce DCM. Bone marrow‐derived macrophages (BMDMs) neonatal rat cardiomyocytes (NRCMs) isolated macrophage polarization,...
This work revealed the importance of microbial succession to microbiota structure and metabolites. Multi-inoculations would promote deterministic assembly. It facilitate regulation metabolic profile. In addition, we established a model predict final metabolites based on genera related succession. was beneficial for optimizing inoculation microbiota. be helpful controlling spontaneous food fermentation directionally improving quality.
Abstract PcINF1 was previously found to induce pepper defense response by interacting with SRC2-1, but the underlying mechanism remains uninvestigated. Herein, we describe involvement of SGT1 in PcINF1/SRC2-1-induced immunity. observed be up-regulated Phytophthora capsici inoculation and synergistically transient overexpression / SRC2-1 plants. -silencing compromised HR cell death, blocked H 2 O accumulation downregulated HR-associated hormones-dependent marker genes’ expression triggered...
Abstract CaWRKY40 is a positive regulator of pepper ( Capsicum annum ) response to Ralstonia solanacearum inoculation (RSI), but the underlying mechanism remains largely unknown. Here, we functionally characterize CaCDPK15 in defense signaling mediated by CaWRKY40. Pathogen-responsive TGA, W, and ERE boxes were identified promoter (p ), p -driven GUS expression was significantly enhanced RSI exogenously applied salicylic acid, methyl jasmonate, abscisic ethephon. Virus-induced gene silencing...
Summary Chitin is a structural and functional component of the fungal cell wall also serves as pathogen‐associated molecular pattern (PAMP) that triggers innate immune responses host plants. However, no or very little chitin found in fungus‐like oomycetes. In Phytophthora spp., presence has not been demonstrated so far, although putative synthase (CHS) genes, which encode enzymes synthesize chitin, are present their genomes. Here, we revealed zoospores released sporangia , this most...
Phytophthora capsici is a broad-host range oomycete pathogen that can cause severe phytophthora blight disease of pepper and hundreds other plant species worldwide. Natural resistance against P. inadequate, it very difficult to control by most existing chemical fungicides. Therefore, urgent develop alternative strategies this pathogen. Recently, host-induced or spray-induced gene silencing essential virulent genes provided an effective strategy for controls. Here, we demonstrate effectively...