A5020249985- Nanoparticle-Based Drug Delivery
- Drug Solubulity and Delivery Systems
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Advanced Drug Delivery Systems
- Crystallization and Solubility Studies
- Advanced biosensing and bioanalysis techniques
- Advancements in Transdermal Drug Delivery
- Graphene and Nanomaterials Applications
- HIV Research and Treatment
- Lipid Membrane Structure and Behavior
- Extracellular vesicles in disease
- Erythrocyte Function and Pathophysiology
- Drug Transport and Resistance Mechanisms
- Analytical Methods in Pharmaceuticals
- Curcumin's Biomedical Applications
- Immune cells in cancer
- Alzheimer's disease research and treatments
- Inhalation and Respiratory Drug Delivery
- Traumatic Brain Injury and Neurovascular Disturbances
- Nanoparticles: synthesis and applications
- Radiation Therapy and Dosimetry
- Pediatric health and respiratory diseases
- HIV/AIDS drug development and treatment
- Heavy Metal Exposure and Toxicity
Henan University
2021-2024
Naval University of Engineering
2024
Academy of Military Medical Sciences
2022
Shenyang Pharmaceutical University
2021-2022
Union Hospital
2022
Anshan Hospital
2003-2021
Institute of Pharmacology
2015
Huazhong Agricultural University
2013
Neuronal mitochondrial dysfunction caused by excessive reactive oxygen species (ROS) is an early event of sporadic Alzheimer's disease (AD), and considered to be a key pathologic factor in the progression AD. The targeted delivery antioxidants mitochondria injured neurons brain promising therapeutic strategy for A safe effective drug system (DDS) which able cross blood-brain barrier (BBB) target neuronal necessary. Recently, bioactive materials-based DDS has been widely investigated...
Morinda officinalis oligosaccharides (MOO) are an oral drug approved in China for the treatment of depression China. However, MOO is hardly absorbed so that their anti-depressant mechanism has not been elucidated. Here, we show acted on tryptophan → 5-hydroxytryptophan (5-HTP) serotonin (5-HT) metabolic pathway gut microbiota. could increase hydroxylase levels microbiota which accelerated 5-HTP production from tryptophan; meanwhile, inhibited decarboxylase activity, thus reduced 5-HT...
Glioma is a fatal disease with limited treatment options and very short survival. Although chemotherapy one of the most important strategies in glioma treatment, it remains extremely clinically challenging largely due to blood-brain barrier (BBB) tumor (BBTB). Thus, development nanoparticles both BBB BBTB penetrability, as well glioma-targeting feature, for therapy glioma. New findings nanomedicine are promoting novel biomaterials. Herein, we designed red blood cell membrane-coated solid...
Reactive oxygen species (ROS)-induced neuronal mitochondrial dysfunction is a key pathologic factor in sporadic Alzheimer's disease (AD). Neuronal mitochondria have been proposed to be promising therapeutic target for AD, especially the failures of phase III clinical trials on conventional amyloid-β (Aβ) targeted therapy. However, efficient intravenous delivery agents brain remains major challenge due complicated physiological environment. Recently, biomaterials-based nanomedicine has widely...
Nanosuspensions, as a new drug delivery system for insoluble drugs, are only composed of and small amount stabilizer, which is dispersed in an aqueous solution with high drug-loading, particle size, dispersion, large specific surface area. It can significantly improve the dissolution, bioavailability, efficacy drugs. In this study, paclitaxel nanosuspensions ((PTX)NS) were prepared by ultrasonic precipitation method, characteristics simple preparation easy repetition. With help homologous...
Although many therapeutic strategies for Alzheimer's disease (AD) have been explored, these are seldom used in the clinic. Therefore, AD research is still urgently needed. One major challenge field of nanotherapeutics to increase selective delivery drugs a targeted location. Herein, we devised and tested strategy nanoparticles neurons inhibit tau aggregation by directly targeting p-tau.Curcumin (CUR) loaded onto red blood cell (RBC) membrane-coated PLGA particles bearing T807 molecules...
Abstract Background Glioma is one of the deadliest human cancers. Although many therapeutic strategies for glioma have been explored, these are seldom used in clinic. The challenges facing treatment not only involve development chemotherapeutic drugs and immunotherapeutic agents, but also lack a powerful platform that could deliver two moieties to targeted sites. Herein, we developed chemoimmunotherapy delivery vehicles based on C6 cell membranes DC create hybrid membrane-coated DTX...
Abstract Hollow structured materials with easily modifiable surfaces and enclosed interior spaces have emerged as the most promising candidates in drug delivery systems (DDS). With various functional components inspiring cavities for creative reinvention, response regulation of external internal microenvironment hollow structures enable their ideal capabilities by improving aggregation targeted sites maintaining plasma concentrations at optimal therapeutic ranges. This review begins an...
Colchicine (COL), a widely used natural drug, has potent anti-inflammatory effects; however, as narrow therapeutic index its clinical application is limited by serious gastrointestinal adverse effects, and only oral formulations are currently marketed worldwide. Recent studies have shown that transdermal, injection, drug delivery the three main strategies for COL. This article elaborates on research progress of different in terms toxicity reduction efficacy enhancement, depicting transdermal...
Intratumoral injection is a palliative treatment that aims at further improvement in the survival and quality of life patients with advanced or recurrent carcinomas, cancer severe comorbidities those poor performance status.In this study, solvent-injection method was used to prepare paclitaxel-cholesterol complex-loaded lecithin-chitosan nanoparticles (PTX-CH-loaded LCS_NPs) for intratumoral therapy, physicochemical properties NPs were well characterized.The particle size zeta potential...
Penetration of the blood-brain barrier (BBB) and tumor (BBTB) remains a significant challenge for delivery drugs in treatment glioma. Therefore, development targeted preparations with ability to penetrate BBB BBTB, target gliomas, is an important approach if we are improve efficacy glioma treatment. In current study, active targeting preparation based on PLGA nanoparticles coated erythrocyte membranes (RBCNPs) dual-modified DWSW NGR peptide ligands (DWSW/NGR-RBCNPs). Euphorbia factor L1...
Therapeutic outcome for the treatment of glioma was often limited due to non-targeted nature drugs and physiological barriers, including blood-brain barrier (BBB) tumor (BBTB). An ideal glioma-targeted delivery system must be sufficiently potent cross BBB BBTB then target cells with adequate optimized physiochemical properties biocompatibility. However, it is an enormous challenge researchers engineer above-mentioned features into a single nanocarrier particle. New frontiers in nanomedicine...
Therapeutic outcome for the treatment of glioma was often limited due to non-targeted nature and low permeability drugs across blood-brain barrier (BBB). An ideal glioma-targeted delivery system need traverse BBB then target cells with adequate optimized physiochemical properties biocompatibility. However, it is an enormous challenge researchers engineer above-mentioned features into a single nanocarrier particle. New frontiers in nanomedicine are advancing research new biomaterials. In this...