A5100655195- Fluorine in Organic Chemistry
- Cyclopropane Reaction Mechanisms
- Catalytic C–H Functionalization Methods
- Synthesis and Reactions of Organic Compounds
- Catalytic Alkyne Reactions
- Drug Solubulity and Delivery Systems
- Synthesis and Biological Evaluation
- Synthesis and Catalytic Reactions
- Crystallization and Solubility Studies
- Asymmetric Hydrogenation and Catalysis
- Corrosion Behavior and Inhibition
- Radical Photochemical Reactions
- Protein purification and stability
- Chemistry and Chemical Engineering
- Nanoparticle-Based Drug Delivery
- Ziziphus Jujuba Studies and Applications
- Catalytic Processes in Materials Science
- Oxidative Organic Chemistry Reactions
- Asymmetric Synthesis and Catalysis
- Catalysis and Oxidation Reactions
- Drug Transport and Resistance Mechanisms
- Chemical Synthesis and Analysis
- biodegradable polymer synthesis and properties
- Inorganic Fluorides and Related Compounds
- Electrochemical sensors and biosensors
Wenzhou Medical University
2025
First Affiliated Hospital of Wenzhou Medical University
2025
Tianjin Chengjian University
2024
Baise University
2020-2023
Xuchang University
2021
Xi'an Shiyou University
2014
Shanghai Institute of Organic Chemistry
2010-2013
Huazhong University of Science and Technology
2012
Chinese Academy of Sciences
2012
The gold(I)-catalyzed synthesis of 2-fluoroalkyl imidazole derivatives was developed. Catalyzed by gold(I), propargyl amidines underwent a 5-exo-dig cyclization to afford 2-fluoroalkyl-5-methyl imidazoles. Also, imidazole-5-carbaldehydes were obtained in the presence NIS. A mechanism investigation manifested probable process and carbonyl oxygen derived from O(2).
A new Rh-catalyzed intramolecular coupling reaction of a CF2Br group with 2-aryl indole or pyrrolevia C–H bond activation is presented. This represents way incorporating difluoromethylene groups into organic compounds. Preliminary mechanistic studies suggest that this might not occur via conventional free radical pathway.
Catalyzed by ligand free Pd(OAc)(2), 2,5-disubstituted imidazole was prepared in good yield the reaction of fluorinated propargyl amidines with iodoarene. Mechanistic studies indicated that this transformation occurs through a nitropalladation-reductive elimination pathway.
The first example of Bi(<sc>iii</sc>)-catalyzed aminooxygenation was developed to synthesize 2-fluoroalkyl imidazole-5-carbaldehydes that would decarbonylate efficiently in the presence KO<italic>t</italic>-Bu.
A N-iodosuccinimide (NIS)-mediated divergent and efficient tandem reaction between fluorinated propargyl amidines aromatic o-diamines without any metal catalyst additive under mild conditions was developed for the synthesis of benzo-fused bisimidazoles in moderate to excellent yields. Preliminary mechanistic studies suggested that this proceeded by an intermediate secondary amine derived from 5-iodomethyl imidazole, NIS played another role oxidation reagent promote formation a benzimidazole motif.
A mild and efficient method for the synthesis of N-substituted 2-fluoromethylbenzimidazoles via [bis(trifluoroacetoxy)-iodo]benzene-mediated intramolecular cyclization N,N′-disubstituted bromodifluoro (or trifluoro) ethanimidamides was described.
We hereby describe an instance of diastereoselective trifluoromethanesulfonic acid catalyzed 1,3-dipolar cycloaddition a trifluoromethylated azomethine imine with α,β-ethenyl ketones. Using two different reaction conditions, trifluoroacetaldehyde phenylhydrazone and chalcone derivatives gave polysubstituted pyrazolidines pyrazolines efficiency high diastereoselectivity.
To study the pharmacokinetic effect of different combined administration with monarch drug Ziziphi Spinosae Semen on its main components in rats. Sprague-Dawley (SD) rats were randomly divided into group, Semen-Fructus Schisandrae Chinensis spinosae Semen-Salviae Miltiorrhize Radix et Rhizoma group and Zaoren Ansheng prescription group. After oral administration, HPLC was eluted mobile phase acetonitrle-0.03% phosphate acid water a gradient mode. The detection wavelength 280 nm. parameters...
Abstract Environmental Engineering Organic Hybrid Functionalized Materials A Pd/phosphoramidite‐selenide‐catalyzed highly enantioselective C‐3 allylic alkylation with a wide range of indole nucleophiles has been developed, giving the corresponding products up to 95 % yield and 99 ee.
JFD (N-isoleucyl-4-methyl-1,1-cyclopropyl-1-(4-chlorine)phenyl-2-amylamine·HCl) is a novel investigational anti-obesity drug without obvious cardiotoxicity. The objective of this study was to characterize the key physicochemical properties JFD, including solution-state characterization (ionization constant, partition coefficient, aqueous and pH-solubility profile), solid-state (particle size, thermal analysis, crystallinity hygroscopicity) drug-excipient chemical compatibility. A supporting...
The latest research progress in citrate esters plasticizers at home and abroad was introduced. advance the catalysts for syn thesis of application were reviewed detail. synthesis included sulfonic acid, solid super heteropolyacids, ionic liquids inorganic salts. citric acid ester applied fields food packaging, children's toys medical instrument. development prospects outlined.
Abstract Density functional theory calculations have been performed to explore the mechanism of copper‐catalyzed hydroboration 1,3‐diyne with HBpin. The catalytic cycles are composed three elementary processes in succession, namely, generation copper hydride species, migratory insertion and σ‐bond metathesis, among which metathesis step is rate‐determining a free‐energy barrier 19.7 kcal/mol. syn ‐addition selectivity originates from high for converting ( Z )‐product E )‐product. Effects...
The purpose of this study was to compare the in vitro release and vivo pharmacokinetics bilayer tablets with conventional dispersible nimesulide. were administered beagle dogs plasma levels nimesulide determined by high-performance liquid chromatography-MS/MS. pharmacokinetic parameters calculated using a noncompartmental model. showed biphasic pattern initial burst sustained following quasi-Fickian diffusion-based mechanism. C(max), t(max), mean residence time (MRT), area under curve from 0...
Reported is the synthesis of 2-fluoromethylated quinolines through a copper-catalyzed cyclization N-aryl-fluorinated imidoyl iodides with terminal alkynes. The reaction proceeds in modest to excellent yields and tolerates ortho-, meta- para-substitution on aryl component, although meta-substitution leads mixture products. presence α-H alkyne was found be integral for success this reaction. When non-fluorinated alkynylimines were used as starting materials, pyrrole products formed. This...
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Microbial method with high efficiency and low pollution on oilfield sewage treatment, has more advantages than others, however, the salinity of is rather due to content calcium magnesium ions, sulfate carbonate ions. High results in strong fouling resistance, crystals scale will easily gather deposit microbial surface hinder matter energy exchange processes between outside cell. The worst case that impact normal production. This paper explores principles characteristics dirt deposited...
Abstract A new procedure for the synthesis of fluorinated imidazole derivatives from propargyl amidines is presented.
Abstract leading to 2,5‐disubstituted N‐arylimidazoles