An electrochemical oxydihalogenation of alkynes has been developed for the first time. Using this sustainable protocol, a variety α,α-dihaloketones can be prepared with readily available CHCl3, CH2Cl2, ClCH2CH2Cl, and CH2Br2 as halogen source under conditions at room temperature.

A new bifunctional phosphine catalyst, (2'-hydroxy-biphenyl-2-yl)-diethylphosphane (LBBA-1), was developed for the highly stereoselective synthesis of cis-2,3-dihydrobenzofurans via an aza-Morita-Baylis-Hillman/umpolung addition domino reaction salicyl N-thiophosphinyl imines with electron-deficient allenes. Dual activation both nucleophile and electrophile by catalyst accounts observed high reactivity stereoselectivity.

A novel domino reaction catalyzed by triphenylphosphine was developed for synthesis of the highly functionalized chroman derivatives. The first example that gamma-CH(3) allenoate undergoes cyclization to form derivates reported.

Abstract In recent years, Morita‐Baylis‐Hillman (MBH) carbonates have been extensively used in domino reactions for the synthesis of novel cyclic and acyclic compounds. This review highlights progress made last decade a series compounds from an uncyclized reaction or annulation MBH carbonates, which demonstrates that excellent reactivity high research value as representative substrates organic synthesis. We hope summary understanding can inspire chemists to apply these design more efficient...

The [4+3] annulation reaction of crotonate-derived sulfur ylides with thioaurones has, for the first time, been reported using NaH as base. A diverse array 2,5-dihydrobenzo[4,5]thieno[3,2-b]oxepines is obtained in good to excellent yields. proposed mechanism investigated and supported by DFT calculations.

PPh3-Catalyzed aza-MBH domino reaction of salicyl N-tosylimines with γ-CH3 substituted allenoates is reported. Readily available imines and are converted to benzoxazepine derivatives in one step. Wherein, functionalization C–H bonds γ-substituted allenoate has been developed this process.

Solvent-controlled switchable domino reactions between 2-alkylidenebenzothiophene-3(2H)-ones and Morita–Baylis–Hillamn (MBH) carbonate were developed. All exhibited excellent regioselectivity, producing a broad spectrum of benzothiophene-fused α-pyran, 2,3-dihydrooxepine, oxatricyclodecene derivatives. Furthermore, [4 + 2], 3], related from identical substrates can be controlled.

Abstract Treatment of 2‐phenylpyridines with amino(1,3,2‐dioxaborolan‐2‐yl)diphenylsilane produced fluorosilylated in good to excellent yields under palladium catalysis. This reaction is the first example CH fluorosilylation. Single‐crystal X‐ray structure analysis revealed a Lewis acid–base interaction between silicon and nitrogen atoms, obtained products are silafluorene equivalents. The showed stronger fluorescence than corresponding derivative.

An electrochemical sulfonylation of alkynes with sodium sulfinates was achieved for the first time at room temperature. Employing this electrolysis strategy, reaction occurs efficiently under transition-metal-free, external oxidant-free, and base-free conditions furnishes diverse alkynyl sulfones in satisfactory yield broad functional group tolerance.

This review summarizes the recent advances in cyclization reactions involving pyridinium 1, n -zwitterions ( = 4 and 5) highlights applications of efficient construction heterocycles.

Simple domino reaction: The first aza-MBH/Michael/aldol/dehydrate reaction has been described. In the presence of a bifunctional phosphine organocatalyst N-sulfonated imines and acrolein gave tetrahydropyridine derivatives aza-MBH products selectively in good to excellent yields (see scheme; aza-MBH=aza-Morita–Baylis–Hillman). A practical efficient construction highly functionalized diversified molecules from simple starting materials is desirable remains great challenge. process very...

A straightforward electrosynthesis of carbonyls from aliphatic carboxylic acids has been developed through electrochemical decarboxylative oxygenation. This newly transformation features metal free, ubiquitous substrates, good functional group tolerance, and mild conditions. Diverse primary, secondary, as well tertiary were amenable to this sequence, furnishing valuable ketones, aldehydes, amides in excellent yields. Moreover, preliminary mechanistic studies indicate that the...

The electrochemical triamination of alkynes has been developed, affording a variety 2,3-diimino indolines and 2,3-diamino indoles.

A novel bifunctional phosphine-catalyzed reaction was developed. Cross-Rauhut–Currier, Michael and aldol reactions were successfully combined into a domino process. This method offers powerful approach to the construction of highly substituted cyclohexene skeletons.

Substrate-controlled domino reactions between thioaurones or their analogues and crotonate-derived sulfur ylides were developed produced a broad spectrum of benzothiophene-fused pyran derivatives, substituted chromene derivatives. In these reactions, acting as two-carbon synthons (α β carbons γ carbons) in annulation are reported for the first time. These investigations nicely complement expand previously studied ylides. addition, reaction mechanisms proposed, one which is supported by DFT...

A protocol for the direct functionalization of N–H/α,α,β,β-C(sp³)–H piperidine without any metal or external oxidants is reported.

Addressing the digital divide that plagues rural areas has become an important issue in narrowing urban-rural gap and achieving common prosperity. This article examines impact of network infrastructure on households' ability to cross by using "broadband rural" strategy as a proxy variable for combining data from China Family Panel Studies (CFPS) with score propensity matched difference-in-differences model (PSM-DID). The results show can help farmers access use divide, but does not...

Two efficient synthetic protocols were developed for the synthesis of dibenzothiophene and 1,4-dihydrodibenzothiophene using thioaurones allylic phosphonium salt. Mild reaction conditions, a one-pot procedure, easily accessible starting materials make these powerful tools compounds, which are often used in material pharmaceutical sciences.

Eight-membered cyclic and [5,5]-bicyclic sulfides were synthesized via a domino reaction between thioaurone analogues arynes. Density functional theory calculations performed to elucidate the mechanism, which involves elementary steps of [3 + 2] cycloaddition, 1,2-hydrogen shift, C(sp2)–S bond cleavage as well substituent effect.

The reaction of thioaurone derivatives with allenoate catalyzed by tris(4-methoxyphenyl)phosphane (P(4-MeOC6H4)3) resulted in a domino annulation to produce benzothiophene-fused bridged bicyclic ring, 40-91% yields. advantages the methodology include diastereoselective formation ring single step, very mild conditions, and success resulting from broad functional group. proposed mechanism was tested supported DFT calculations.