Cancer is a genetic disease with frequent somatic DNA alterations. Studying recurrent copy number aberrations (CNAs) in human cancers would enable the elucidation of mechanisms and prioritization candidate oncogenic drivers causal roles oncogenesis. We have comprehensively systematically characterized CNAs accompanying gene expression changes tumors matched nontumor liver tissues from 286 hepatocellular carcinoma (HCC) patients. Our analysis identified 29 recurrently amplified 22 deleted...

Although many therapeutic strategies for Alzheimer's disease (AD) have been explored, these are seldom used in the clinic. Therefore, AD research is still urgently needed. One major challenge field of nanotherapeutics to increase selective delivery drugs a targeted location. Herein, we devised and tested strategy nanoparticles neurons inhibit tau aggregation by directly targeting p-tau.Curcumin (CUR) loaded onto red blood cell (RBC) membrane-coated PLGA particles bearing T807 molecules...

Melatonin is a well-known anti-inflammatory and antioxidant molecule, which plays crucial role in various physiological functions. In this study, mice received single dose of 15 Gy radiation delivered to the lungs daily intraperitoneal administration melatonin. After 7 days, were processed harvest either bronchoalveolar lavage fluid for cytokine assays or flow cytometry histopathological studies. Herein, we showed that melatonin markedly alleviated oxidative stress injury, especially...

SAG (sensitive to apoptosis gene) was cloned as an inducible gene by 1,10-phenanthroline (OP), a redox-sensitive compound and inducer. encodes novel zinc RING finger protein that consists of 113 amino acids with calculated molecular mass 12.6 kDa. is highly conserved during evolution, identities 70% between human Caenorhabditis elegans sequences 55% yeast sequences. In tissues, ubiquitously expressed at high levels in skeletal muscles, heart, testis. localized both the cytoplasm nucleus...

Ethnopharmacological relevance: Sanguinarine (SAG), a natural benzophenanthridine alkaloid derived from the root of Sanguinaria canadensis Linn. (Bloodroot), possesses potential anticancer activity. Lung carcinoma is chief cause malignancy-related mortality in China. Non-small cell lung (NSCLC) main subtype and accounts for about eighty-five percent this disease. Current treatment controlling curing NSCLC remains deficient.The role underlying mechanism SAG repressing growth metastasis were...

Rationale: It has been proposed that cancer stem/progenitor cells (or tumor-initiating cells, TICs) account for breast initiation and progression. Sirtuins are nicotinamide adenine dinucleotide (NAD+)-dependent class-III histone deacetylases mediate various basic biological processes, including metabolic homeostasis. However, interplay cross-regulation among the sirtuin family not fully understood. As one of least studied members, mitochondrial SIRT4 is a tumor suppressor gene in cancers....

Cell-mediated drug delivery system (CDDS) has shown great potential for cancer therapy. However, a single cell-mediated mechanism not generally been successful, particularly systemic administration. To augment the antitumor therapy efficacy, herein, we propose strategy of cell relay-delivery use artificially damaging/aging erythrocytes to hitchhike on circulating monocytes/macrophages intratumoral accumulation anticancer drugs. This biomimetic was derived from manner in which body...

To explore the effect of long-term traditional Chinese medicine (TCM) treatment on survival time colorectal cancer (hereinafter referred to as CRC).Our clinical study included patients who were diagnosed with CRC clinically or pathologically. Patients divided into TCM group and control according whether modified Anti-cancer Decoction II Formula was applied for more than six months. Propensity score matching PSM) used further balance covariates between groups. One-year six-year...

Abstract Sepsis was redefined as life-threatening organ dysfunction caused by a dysregulated host response to infection in 2016. One of its most common causes is Staphylococcus aureus, especially methicillin-resistant aureus (MRSA), which leads significant increase morbidity and mortality. Therefore, innovative effective approaches combat MRSA are urgently needed. Recently, host-directed therapy (HDT) has become new strategy the treatment infectious diseases, those antibiotic-resistant...

Autophagy is a host machinery that controls cellular health. Dysfunction of autophagy responsible for the pathogenesis many human diseases include atherosclerosis obliterans (ASO). Physiologically, removes aging organelles and delays formation atherosclerotic plaque. However, in ischemia event, dysregulated can be induced to trigger autosis, leading an inevitable death. Grb2-associated binder 1 (GAB1) docking/scaffolding adaptor protein regulates cell processes including autophagy. Our study...

Background Clinical trials showed limited benefit of anti-PD-1 (programmed cell death 1) monotherapy in pancreatic adenocarcinoma patients and immune-related adverse events caused by immune checkpoint inhibitors were rarely reported adenocarcinoma. Here, we report the first case durable along with systemic lupus erythematosus following immunotherapy mismatch repair-proficient cancer. Case presentation We describe a 57-year-old woman resected stage ⅢB cancer who underwent several lines...

Abstract Increasing evidence shows the oncogenic function of FAM83D in human cancer, but how exerts its remains largely unclear. Here, we investigated importance FAM83D/FBXW7 interaction breast cancer (BC). We systematically mapped FBXW7-binding sites on through a comprehensive mutational analysis together with co-immunoprecipitation assay. Mutations at led to that lost capability promote ubiquitination and proteasomal degradation FBXW7; cell proliferation, migration, invasion vitro; tumor...

It has been demonstrated that epidermal growth factor receptor (EGFR) signal pathway had an important role in the oncogenesis and development of non-small cell lung cancer (NSCLC). Small-molecule tyrosine kinase inhibitors (TKIs) target at domain EGFR are recently developed therapy reagents for treatment NSCLC patients. Previous studies revealed different patient groups response differently to EGFR-TKI, which is based on gene status. The aim this research was define clinicopathologic...

Chinese herbal Fu‐Zheng‐Qu‐Xie (FZQX) prescription has been found to improve the immune function and survival of patients with early‐stage lung cancer. However, therapeutic efficacy needs be evaluated objectively, precise mechanism remains unclear. In present study, a double‐center, prospective cohort study was carried out assess clinical FZQX in preventing recurrence metastasis postoperative adenocarcinoma. Our results indicated that could significantly reduce 3‐year rate life quality....

Yu-Ping-Feng (YPF) formula is a classical prescription used for enhancing the body’s immunity function in traditional Chinese medicine (TCM). In clinical practice, YPF has been reported to exhibit antilung cancer and immunomodulatory effect. However, relationship between them remains unclear. The present study aimed investigate effect of its immune-related mechanisms. C57BL/6 tumor-bearing mice model was established randomly divided into group control group. Tumor volume, spleen weight,...

To explore the efficacy of long-term use Chinese herbal medicine (CHM) on survival time lung cancer.We conducted a retrospective cohort study cancer patients. A propensity score matching (PSM) was performed to balance covariates. Progression-free (PFS) primary endpoint and overall (OS) secondary endpoint. Patients who received CHM therapy from initial date diagnosis were included in group. not treated with during same interval categorized control Cox regression model used prognostic factors...

BACKGROUND Lung adenocarcinoma (LUAD) is the predominant histological type of lung cancer with high morbidity and mortality. Ferroptosis regarded as a new pattern programmed cell death concerned progression characterized by lipid peroxidation. Nevertheless, prognostic role ferroptosis-related genes for LUAD warrant to be explored. MATERIAL AND METHODS RNA sequencing relevant clinical patient data were obtained from public-access databanks. A model was constructed through LASSO Cox regression...

Lung cancer is a malignancy characterized by high morbidity and mortality, with lung adenocarcinoma being the most prevalent subtype. Our preliminary studies have demonstrated that Juan-Liu-San-Jie (JLSJ) prescription, Traditional Chinese Medicine possesses anti-lung properties. However, molecular mechanism underlying therapeutic effects of JLSJ prescription for remains incompletely elucidated. To address knowledge gap, present study employed network pharmacology to identify potential...

Aristolochic acid I (AAI) is a natural bioactive substance found in plants from the Aristolochiaceae family and impairs spermatogenesis. However, whether AAI-induced spermatogenesis impairment starts at early stages of has not yet been determined. Spermatogonial stem cells (SSCs) are undifferentiated spermatogonia that balance self-renewing differentiating divisions to maintain throughout adult life only capable passing genes onto next generation. The objective this study was investigate AAI...

Gallbladder carcinoma (GBC) with proficient mismatch repair (pMMR)/microsatellite stable (MSS) is associated limited response to programmed death-1 (PD-1) inhibitor monotherapy. Limited data of PD-1 blockade combined anti-angiogenic therapy in GBC are reported. One recurrent patient pMMR/MSS was treated camrelizumab plus apatinib. After 4 cycles combination therapy, the achieved a durable complete manageable toxicity. The next-generation sequencing and immunohistochemistry analysis showed...