A5100764864- Animal Nutrition and Physiology
- Autophagy in Disease and Therapy
- MicroRNA in disease regulation
- Data Visualization and Analytics
- Medical Imaging Techniques and Applications
- Aquaculture Nutrition and Growth
- Mesenchymal stem cell research
- Network Security and Intrusion Detection
- Extracellular vesicles in disease
- Effects of Environmental Stressors on Livestock
- Advanced X-ray and CT Imaging
- Genomics, phytochemicals, and oxidative stress
- Endoplasmic Reticulum Stress and Disease
- Ovarian function and disorders
- Cryptography and Data Security
- Chemotherapy-induced organ toxicity mitigation
- Digital Radiography and Breast Imaging
- Berberine and alkaloids research
- Cell Adhesion Molecules Research
- Cancer-related gene regulation
- Technology and Security Systems
- Wnt/β-catenin signaling in development and cancer
- Alkaloids: synthesis and pharmacology
- Advanced Differential Geometry Research
- Agriculture Sustainability and Environmental Impact
First People's Hospital of Foshan
2024
Jiangsu University
2022-2024
Shandong Agricultural University
2020-2024
Ministry of Agriculture and Rural Affairs
2023-2024
Second Hospital of Shandong University
2020-2024
Guizhou Provincial People's Hospital
2023
Taihe Hospital
2022
Hubei University of Medicine
2022
Star Technology and Research (United States)
2022
Renji Hospital
2018-2021
Induced pluripotent stem cell (iPSC) derived endothelial cells (ECs) is a novel therapeutic option for ischemic diseases.Although the detailed mechanism of this therapy remains unknown, emerging evidence has demonstrated that exosomes from hiPSC-ECs play critical role in approach.In study, we first isolated and characterized iPSCs-ECs (hiPSC-EC-Exo) determined functional roles hiPSC-EC-Exo neovascularization underlying mechanism.Further, evaluated effect hiPS-ECs on promoting angiogenesis...
Bile acids (BA), a series of hydroxylated steroids secreted by the liver, are involved in digestion and absorption dietary fats. In present study, effect exogenous BAs on performance liver lipid metabolism laying hens was investigated. Three hundred sixty 50-wk-old Hy-line Brown were randomly allocated into three groups subjected to one following treatments: fed with basal diet (control, Con), supplemented 0.1 g/kg (0.1 BAs), or 0.2 (0.2 BAs) porcine BAs. Laying performance, egg quality,...
Gliomas arise in the glial cells of brain or spine and are most prevalent devastating type tumors. Studies tumor immunology have established importance micro-environment as a driver oncogenesis. Inflammatory mediators such IL-1β IL-18 released by monocytes regulate transcriptional networks that required for malignant cell growth. Berberine is natural botanical alkaloid widely found Berberis species. Although it has been used an anti-diarrheal treatment North America several decades, our...
Abstract ORMDL sphingolipid biosynthesis regulator 3 (ORMDL3) is a universally confirmed susceptibility gene for asthma and has recently emerged as crucial modulator in lipid metabolism, inflammation endoplasmic reticulum (ER) stress-the mechanisms also closely involved atherosclerosis (AS). Here we first presented the evidence of two single nucleotide polymorphisms regulating ORMDL3 expression (rs7216389 rs9303277) significantly associated with AS risk increased cases compared to controls,...
The genetic association of orosomucoid-like 3 (ORMDL3) with an array immunoinflammatory disorders has been recently unraveled in multiple ethnic groups, and functional exploration received attention the particular relevance this gene endoplasmic reticulum stress, lipid metabolism, inflammatory response. In study, we demonstrated upregulation ORMDL3 both patients systemic lupus erythematosus mice compared controls. By establishing knockout (Ormdl3-/-), showed that silencing Ormdl3 vivo...
The present study was designed to investigate whether L-arginine (Arg) supplementation would influence the production performance and reproductive traits of laying hens fed low crude protein (LCP) diets. Hy-Line brown were randomly assigned dietary treatments control, LCP, LCP supplemented with 0.05, 0.10, 0.15, or 0.20% Arg for 7 wk. results showed no significant variations on performance, relative organ indexes hens. However, transcriptional structural changes evident along HPG axis...
Dietary energy density influences feed intake and development of layer-type pullets. A total 384 9-week-old Hy-Line Brown pullets were randomly assigned to one three dietary treatments: fed a diet with 2,600, 2,750, 2,900 Kcal metabolizable energy/kg (ME/kg) from 10 21 weeks age. The results showed that the 2,600 ME groups had lower (P < 0.01) heavier body weight (BW) longer shank length 0.05) at age than 2,750 group. eggshell percentage was increased by kcal/kg treatments = 0.002). Serum...
Orosomucoid-like 3 (ORMDL3) has been associated with asthma and a series of autoimmune disorders, is involved in endoplasmic reticulum-mediated inflammatory responses. However, its clinical significance the molecular mechanism underlying expression are still largely unclear. To elucidate mechanisms human ORMDL3 transcriptional regulation, we cloned 1.5 kb genomic DNA fragment containing putative promoter region evaluated activity luciferase reporter system by deletion analysis. We identified...
Nutrition during the pre-lay period takes effect on production performance in laying flock. This study evaluated effects of dietary energy and protein levels diet whole egg quality, bone mRNA expression hypothalamus-pituitary-gonadal (HPG) axis-related genes hens at end cycle. A total 1,856 15-wk old Hy-Line brown pullets were randomly assigned to one four treatments: using a 2 × factorial arrangement with (2,700 2,800 kcal/kg ME, respectively) (15 16.5% CP, respectively). Pullets fed ad...
Autophagy is a host machinery that controls cellular health. Dysfunction of autophagy responsible for the pathogenesis many human diseases include atherosclerosis obliterans (ASO). Physiologically, removes aging organelles and delays formation atherosclerotic plaque. However, in ischemia event, dysregulated can be induced to trigger autosis, leading an inevitable death. Grb2-associated binder 1 (GAB1) docking/scaffolding adaptor protein regulates cell processes including autophagy. Our study...
Calcium (Ca) and phosphorus (P) transporters are responsible for their absorption transport in small intestine kidney, contributing to eggshell formation. The light-dark cycle is a primary cue the reproduction of laying hen. In this study, we investigated effect different programs on quality expression genes related Ca P transportation hens. Seventy-two 56-week-old hens were randomly divided into two groups reared at 16-h light 8-h dark (control) or 9-h 15-h regime (long phase, LDP)....
To analyze the types and functions of CD34
Studies have shown that the inflammatory activation of miroglia (MG) and nuclear factor kappa B ( NF-κB ) play a dominant role in response. Previous studies sinomenine, an anti-inflammatory agent extracted from Sinomenium acutum, can directly protect neurons against cerebral ischemia injury. However, there are no reports on its effect ischemia/reperfusion-induced MG. In present study, vitro ischemia/reperfusion model was developed with mouse BV-2 microglia cells, oxygen-glucose...
Primary pulmonary epithelioid angiosarcoma is a rare tumor type without any specific clinical and imaging features. Therefore, it associated with high rates of misdiagnosis. The present study reports the case 54‑year‑old female patient who was admitted after complaining cough, expectoration bloody sputum for >5 months in May 2021. reported previous history papillary thyroid carcinoma 2003 had undergone treatment through surgery, postoperative chemotherapy iodine131 therapy. Chest computed...
Lung cancer has become a global health issue in recent decades. Approximately 80-85% of cases are non-small-cell lung (NSCLC). Despite the high rate resistance, cisplatin-base chemotherapy is still main treatment for NSCLC patients. Thus, overcoming cisplatin resistance urgently needed therapy. In this study, we identify NADPH metabolism and reactive oxygen species (ROS) levels as causes accounting resistance. Based on small panel consisting common drugs or compounds, APR-246 proved to be an...
Parecoxib, a non-steroidal anti-inflammatory drug, has been reported to possess protective effects against sepsis. However, its detailed role and underlying mechanisms in septic cardiomyopathy remain unclear. Therefore, the goal of present study was clarify function investigate parecoxib lipopolysaccharide (LPS)-treated H9c2 rat cardiomyocytes. TNF-α, IL-1β IL-6 expression levels parecoxib-treated cells stimulated with LPS were assessed using ELISA. Parecoxib-treated tested for viability...
High ambient temperature is a major environmental stressor affecting poultry production, especially in the tropical and subtropical regions of world. Nutritional interventions have been adopted to combat thermal stress poultry, including use amino acids. L-citrulline nonessential acid that involved nitric oxide generation thermoregulation, however, molecular mechanisms behind L-citrulline's regulation body are still unascertained. This study investigated global gene expression hypothalamus...
The underlying mechanism behind the deteriorated laying performance of aged hens remains unclear. In present study, and gene expression along hypothalamus-pituitary-gonad axis were determined. A total 300 healthy 90-wk-old ISA with similar body weights classified into three groups according to their rate between 90 94 wk age. experimental low (<60%, LLR), high (>85%, HLR), intermediate (60% < 85%, MLR) hens. At end age, eight randomly selected from each group for tissue collection. hormones...
Ligustrazine is a Chinese herb (Chuanxiong) approved for use as medical drug in China. Recent evidence suggests that ligustrazine has promising antitumor properties. Our preliminary results showed could inhibit the growth of human renal cell carcinoma (RCC) lines. However, complicated molecular mechanism not been fully revealed. Therefore, purpose this study to investigate resistance RCC cells. Cell proliferation, migration, invasion, and colony-formation ability cells A498 were detected by...
Abstract Background: Arteriosclerosis obliterans (ASO) is a major cause of adult limb loss worldwide. Autophagy vascular endothelial cell (VEC) contributes to the ASO progression. However, molecular mechanism that controls VEC autophagy remains unclear. In this study, we aimed explore role GRB2 associated binding protein 1 (GAB1) in regulating autophagy. Methods: vivo and vitro studies were applied determine adapt GAB1 association with Histological expression was measured sclerotic intima...