A5015849886- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- Lung Cancer Treatments and Mutations
- Immunotherapy and Immune Responses
- Colorectal Cancer Treatments and Studies
- Immune Cell Function and Interaction
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Genetic factors in colorectal cancer
- Lung Cancer Research Studies
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Cancer-related molecular mechanisms research
- Immune cells in cancer
- RNA modifications and cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- T-cell and B-cell Immunology
- Bladder and Urothelial Cancer Treatments
- Gastric Cancer Management and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- vaccines and immunoinformatics approaches
- Hip disorders and treatments
- Orthopaedic implants and arthroplasty
- Immune Response and Inflammation
Southern Medical University
2020-2024
Capital Medical University
2012-2024
Genecast (China)
2018-2024
Beijing Shijitan Hospital
2021-2024
Nanfang Hospital
2022-2024
Foshan University
2024
Taiyuan Institute of Technology
2018-2024
Hebei Normal University of Science and Technology
2024
Shanxi University
2024
Beijing Ditan Hospital
2017-2023
PD-L1 expression on neutrophils contributes to the impaired immune response in infectious disease, but detailed role of HCC remains unclear. We investigated phenotype and morphology infiltrated tumour tissues from both patients with hepatoma-bearing mice. found that dominantly peritumoural region. The neutrophil-to-T cell ratio (NLR) was higher tissue than intratumoural negatively correlated overall survival HCC. Infiltrating displayed a frequency programmed death ligand 1 (PD-L1) positive...
Background Tumor mutational burden (TMB) is a significant predictor of immune checkpoint inhibitors (ICIs) efficacy. This study investigated the correlation between deep learning radiomic biomarker and TMB, including its predictive value for ICIs treatment response in patients with advanced non-small-cell lung cancer (NSCLC). Methods CT images from 327 TMB data (TMB median=6.067 mutations per megabase (range: 0 to 42.151)) were retrospectively collected randomly divided into training...
HBV infection continues to be an important worldwide cause of morbidity and mortality. Patients with chronic hepatitis B can successfully treated using nucleoside/nucleotide analogues. However, drug-resistant mutants frequently arise, leading treatment failure progression liver disease. Here, we report the effects GLS4, a non-nucleosidic inhibitor that exhibits novel highly specific anti-HBV activity.The median inhibitory concentrations (IC(50)s) GLS4 on were measured by Southern blotting....
To depict the genomic landscape of Chinese early-stage lung squamous cell carcinoma (LUSC) and investigate its correlation with tumor mutation burden (TMB), PD-L1 expression, immune infiltrates. Whole-exome sequencing was performed on 189 surgically resected LUSC. TMB defined as sum nonsynonymous single nucleotide indel variants. CD8+ tumor-infiltrating lymphocyte (TIL) density expression were evaluated by immunohistochemistry. Six infiltrates estimated using an online database. The median...
Several targeted immunotherapies have recently showed significant advances in treatment of non-small cell lung cancer (NSCLC), including antibodies and inhibitors targeting programmed death-1 (PD-1) its ligand (PD-L1).Tumor tissue samples were prospectively collected from 183 patients with NSCLC adenocarcinoma (ADC) squamous carcinoma (SQCC). PD-L1 expression level was measured by immunohistochemistry assay tumor mutational burden (TMB) status assessed next generation sequencing....
Background The global outbreak of coronavirus disease 2019 (COVID-19) has turned into a worldwide public health crisis and caused more than 100,000,000 severe cases. Progressive lymphopenia, especially in T cells, was prominent clinical feature COVID-19. Activated HLA-DR + CD38 CD8 cells were enriched over prolonged period from the lymphopenia patients who died Ebola influenza infection infected with SARS-CoV-2. However, population reported to play contradictory roles SARS-CoV-2 infection....
The genomic spectrum of biliary tract carcinoma (BTC) has been characterized and is associated with distinct anatomic etiologic subtypes, yet limited studies have linked alterations personalized therapies in BTC patients.
Epidermal growth factor receptor (EGFR) is reportedly overexpressed in most esophageal squamous cell carcinoma (ESCC) patients, but anti-EGFR treatments offer limited survival benefits. Our preclinical data showed the promising antitumor activity of afatinib EGFR-overexpressing ESCC. This proof-of-concept, phase II trial assessed efficacy and safety pretreated metastatic ESCC patients (n = 41) with EGFR overexpression (NCT03940976). The study met its primary endpoint, a confirmed objective...
Background Despite the great achievements made in immune-checkpoint-blockade (ICB) cancer therapy, there are no effective predictive biomarkers gastrointestinal (GI) cancer. Methods This study included 93 metastatic GI patients treated with ICBs. The first cohort comprising 73 were randomly assigned into discovery (n=44) and validation (n=29) cohorts. Comprehensive genomic profiling was performed on all samples to determine tumor mutational burden (TMB) copy-number alterations (CNAs). A...
Programmed cell death ligand 1 (PD-L1) expressed on tumor and immune cells are both associated with the response to programmed (PD-1) pathway blockade therapy. Here, we examine role of CD8+PD-L1+ tumor-infiltrating lymphocyte (Tils) in microenvironment non-small lung cancer (NSCLC).Tumor tissue samples a total 378 patients from two NSCLC cohorts were collected retrospectively. Tumor genetic variations measured by targeted next-generation sequencing 543 oncogenes. Tils assessed multiplex...
Although traditional treatments confer survival benefits to patients with gastric cancer (GC), many experience relapse soon after postoperative adjuvant therapy. Immune-related mechanisms play an important role in GC, and immunotherapeutic strategies are considered be a promising direction for the treatment of GC. Thus, our study aimed investigate expression prognostic significance immune-related genes GC.Formalin-fixed, paraffin-embedded samples were collected from 48 resectable GC...
Objective Immune imbalance between regulatory T (Treg) and Th17 cells is a characteristic of systemic sclerosis (SSc). The functional heterogeneity among Treg can be elucidated by separating into different subsets based on the expression FoxP3 CD45RA. aim this study was to investigate role in immune naïve SSc. Methods Peripheral blood mononuclear (PBMCs) 31 SSc patients 33 healthy controls were analyzed for CD4, CD25, CD45RA, CTLA-4, FoxP3, IL-17 using flow cytometry. immunesuppression...
Immune checkpoint inhibitors (ICIs) have revolutionized the therapeutic landscape of gastrointestinal cancer. However, biomarkers correlated with efficacy ICIs in cancer are still lacking. In this study, we performed 395-plex immune oncology (IO)-related gene target sequencing tumor samples from 96 patients metastatic treated ICIs, and a linear support vector machine learning strategy was applied to construct predictive model. ResultsAll were randomly assigned into discovery (n=72)...
Background DNA damage repair (DDR) genes were recently implicated in the anti-tumor immune response. Therefore, it is worthwhile to unravel implications of DDR pathways shaping responsiveness colorectal cancer (CRC) patients receiving checkpoint inhibitors (ICI). Methods We analyzed publicly available genomic data from a cohort treated with ICI Memorial Sloan Kettering Cancer Center (MSK cohort). To characterize impact mutation, The Genome Atlas (TCGA) adenocarcinoma (COADREAD) dataset was...
Background This study was designed to screen potential biomarkers in plasma cell-free DNA (cfDNA) for predicting the clinical outcome of immune checkpoint inhibitor (ICI)-based therapy advanced hepatobiliary cancers. Methods Three cohorts including 187 patients with cancers were recruited from trials at Peking Union Medical College Hospital. Forty-three received combination programmed cell death protein 1 (PD-1) lenvatinib (ICI cohort 1), 108 ICI-based 2) and 36 non-ICI (non-ICI cohort). The...
Several clinical trials have shown the safety and effectiveness of PD-1/PD-L1 inhibitors in neoadjuvant therapy resectable non-small cell lung cancer (NSCLC). However, 18-83% patients can benefit from it. In this study, we aimed to assess association PD-L1 expression, tumor mutation burden, copy number alteration (CNA, including gain loss) burden with pathologic response PD-1 blockade investigate changes immune microenvironment (TIME) during immunotherapy NSCLC. Pre-immunotherapy treatment...
Immune checkpoint inhibitors (ICIs) have dramatically improved survival in advanced gastrointestinal (GI) cancer patients, but also resulted immune-related adverse events (irAEs). This study aimed to evaluate serological biomarkers of irAEs and treatment response GI patients.Metastatic patients were enrolled between August 1, 2015, July 31, 2017. Serum samples collected at baseline, a panel 59 serum was tested. The occurrence analyzed, biomarker expression correlated with irAE incidence...
Viral infection is a common cause of olfactory dysfunction. The complexities studying post-viral loss in humans have impaired further progress understanding the underlying mechanism. Recently, evidence from clinical studies has implicated Parainfluenza virus 3 as causal agent. An animal model post viral disorders (PVOD) would allow better disease pathogenesis and represent major advance field.To develop mouse PVOD by evaluating effects Sendai (SeV), murine counterpart virus, on function...