A5078048108- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Cancer, Stress, Anesthesia, and Immune Response
- Prostate Cancer Treatment and Research
- Epigenetics and DNA Methylation
- Pesticide and Herbicide Environmental Studies
- Weed Control and Herbicide Applications
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Plant tissue culture and regeneration
- Ferroptosis and cancer prognosis
- Cancer-related gene regulation
- Cancer Research and Treatments
- Autophagy in Disease and Therapy
- Protein Kinase Regulation and GTPase Signaling
- Glutathione Transferases and Polymorphisms
- Bladder and Urothelial Cancer Treatments
- Gyrotron and Vacuum Electronics Research
- Plant Gene Expression Analysis
- Garlic and Onion Studies
- Inflammatory mediators and NSAID effects
- Endoplasmic Reticulum Stress and Disease
- PI3K/AKT/mTOR signaling in cancer
- RNA Research and Splicing
- Chemokine receptors and signaling
Southern Medical University
2016-2025
Aerospace Information Research Institute
2023-2024
Chinese Academy of Sciences
2021-2024
University of Chinese Academy of Sciences
2021-2023
Institut Pasteur of Shanghai
2021-2023
The Affiliated Yongchuan Hospital of Chongqing Medical University
2015-2020
Chongqing Medical University
2015-2020
Hubei University of Medicine
2017-2019
Taihe Hospital
2017-2019
Guangdong Medical College
2017-2018
Cell death limits pathogens During infection, Yersinia inhibition of the protein kinase TAK1 triggers cleavage pore-forming gasdermin D (GSDMD), which leads to a kind inflammatory cell called pyroptosis. In genome-wide screen, Zheng et al. identified lysosome-tethered regulatory supercomplex as being critical driver -induced The activity GTPase Rag and lysosomal tethering Rag-Ragulator were required recruit activate RIPK1 protease caspase-8 cleave GSDMD, causes infection. By contrast, was...
Phosphoglycerate dehydrogenase (PHGDH), the rate-limiting enzyme in first step of serine synthesis pathway (SSP), is overexpressed multiple types cancers. The androgen receptor inhibitor enzalutamide (Enza) primary therapeutic drug for patients with castration-resistant prostate cancer (CRPC). However, most eventually develop resistance to Enza. association SSP Enza remains unclear. In this study, we found that high expression PHGDH was associated CRPC cells. Moreover, increased led...
This study was to explore the infiltration pattern of immune cells in prostate cancer (PCa) microenvironment and evaluate possibility specific infiltrating as potential prognostic biomarkers PCa.Infiltrating percentage 22 were extracted from 27 normalized datasets by CIBERSORT algorithm. Samples with p-value < 0.05 subsequently merged divided into normal or tumor groups. The differences between tissues analyzed along correlations among Gleason grades. SNV data TCGA used calculate TMB score....
Toll-like receptor 4 (TLR4) sensing of lipopolysaccharide (LPS), the most potent pathogen-associated molecular pattern gram-negative bacteria, activates NF-κB and Irf3, which induces inflammatory cytokines interferons that trigger an intense response, is critical for host defense but can also cause serious pathology, including sepsis. Although TLR4 inhibition attractive therapeutic approach suppressing overexuberant signaling, previously identified antagonists have not shown any clinical...
Glioblastoma (GBM) is a highly aggressive form of brain tumor characterized by dysregulated metabolism. Increased fatty acid oxidation (FAO) protects cells from lipid peroxidation-induced cell death, although the precise mechanisms involved remain unclear. Herein, we report that loss necrosis factor receptor-associated 3 (TRAF3) in GBM critically regulates peroxidation and tumorigenesis controlling polyunsaturated acids (PUFAs). TRAF3 frequently repressed due to promoter hypermethylation....
Protein kinase D (PKD) is a family of novel diacylglycerol/phorbol ester targets that regulate many important cellular functions including cell growth and survival. We now provide experimental evidence to indicate PKD3 contributes prostate cancer Expression as well PKD1 was significantly higher in human tumors compared with normal tissues revealed by immunohistochemistry. Moreover, exhibited marked increase nuclear localization tumor tissues, which correlated grade. Isoforms PKD were...
Although protein kinase D3 (PKD3) has been shown to contribute prostate cancer cell growth and survival, the role of PKD in motility remains unclear. Here, we show that PKD2 PKD3 promote nuclear factor kappa B (NF-κB) signaling urokinase-type plasminogen activator (uPA) expression/activation, which are crucial for invasion. Silencing endogenous and/or markedly decreased migration invasion, reduced uPA receptor (uPAR) expression increased inhibitor-2 (PAI-2) expression. These results were...
This study investigated the protective properties and mechanisms of D-mannose against hepatic steatosis in experimental alcoholic liver disease (ALD). Drinking-water supplementation significantly attenuated a standard mouse ALD model established by chronic-binge ethanol feeding, especially hepatocyte lipid deposition. function on accumulation hepatocytes was also confirmed using ethanol-treated primary (PMHs) with supplement. Meanwhile, regulated metabolism rescuing ethanol-mediated...
Mast cells are being increasingly recognized as critical components in the tumor microenvironment. Protein Kinase D (PKD) is essential for progression of prostate cancer, but its role cancer microenvironment remains poorly understood.The expression PKD, mast and microvessel density were examined by IHC. The clinical significance was determined statistical analyses. biological function PKD underlying mechanisms investigated using vitro vivo models.PKD2/3 contributed to MCs recruitment...
Pyruvate kinase M2 (PKM2) is a key enzyme of glycolysis, which highly expressed in many tumor cells, and has emerged as an important player progression metastasis. However, the functional roles PKM2 metastasis remain elusive. Here we showed that promoted prostate cancer via extracellular-regulated protein (ERK)–cyclooxygenase (COX-2) signaling. Based on public databases, found expression was upregulated positively associated with Further analysis cell migration/invasion...
Background The human insulin-like growth factor 2 mRNA binding proteins 1–3 (IGF2BP1–3, also called IMP1–3) play essential roles in regulation, including its splicing, translocation, stability, and translation. However, knowledge regarding the involvement of IGF2BPs tumor immunity stemness across cancer types is still lacking. Methods In this study, we comprehensively analyzed pan-cancer multi-omic data to determine correlation protein expression with various parameters such as mutation...
Cathepsin V (CTSV) is a cysteine cathepsin protease that plays crucial role in extracellular matrix degradation. CTSV correlated with poor prognosis various cancers, but the underlying mechanism remains elusive. Here, we observed CSTV upregulated lung cancer and factor for cancer. acts as driver metastasis of both vitro vivo. promotes by downregulating adhesion molecules, including fibronectin, E-cadherin, N-cadherin. Our data revealed functions mediating fragmentation N-cadherin cleavage,...
Chronic stress is well known to promote tumor progression, however, little whether chronic stress-mediated regulation of osteoblasts contributes the migration and invasion metastatic cancer cells.The proliferation, prostate cells were assessed by CCK-8 transwell assay. HIF-1α expression epithelial-mesenchymal transition (EMT) markers examined Western blot. The mRNA level cytokines associated with bone metastasis in EMT PC-3 DU145 performed qRT-PCR. Functional rescue experiment using siRNA,...
Liver fibrosis represents a hallmark of most chronic liver diseases (CLD) triggered by recurrent injury and subsequent myofibroblast transdifferentiations resident hepatic stellate cells (HSCs). Mannan-binding lectin (MBL) is potentially involved in CLD through unclear mechanisms. Therefore, we investigated the crosstalk between MBL HSCs, consequent effects on progression.
Abstract Bladder cancer (BCa) is a prevalent malignancy with poor prognosis. SLC7A7 has been linked to BCa progression and angiogenesis, but its specific role remains unclear. We established SLC7A7-knockdown cell line investigate effects on angiogenesis. In vivo experiments assessed tumor vascularization, while in vitro studies explored exosome involvement. MiRNA sequencing identified miR-152-3p as key regulator. Further investigation using dual-luciferase reporter assays, qRT-PCR, Western...
Protein kinase D (PKD) has been implicated in many aspects of tumorigenesis and progression, is an emerging molecular target for the development anticancer therapy. Despite recent advancement potent selective PKD small molecule inhibitors, availability vivo active inhibitors remains sparse. In this study, we describe discovery a novel inhibitor, SD-208, from targeted inhibitor library screen, synthesis series analogs to probe structure-activity relationship (SAR) vs. PKD1. SD-208 displayed...
Hepatocellular carcinoma (HCC) is one of the leading causes cancer-related deaths worldwide. Although sorafenib a standard first-line molecule-targeted drug against advanced HCC, resistance development and adverse side effects usually limit its efficacy. This study investigated effect fucoidan on sensitivity sorafenib-resistant human HCC cell line HepG2-SR established by long-time exposure HepG2 to sorafenib. We demonstrated combined with synergistically promoted apoptosis cycle arrest...