A5101856388- Bladder and Urothelial Cancer Treatments
- Cancer Research and Treatments
- Cancer Immunotherapy and Biomarkers
- Urinary and Genital Oncology Studies
- Renal cell carcinoma treatment
- Ferroptosis and cancer prognosis
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Urological Disorders and Treatments
- Epigenetics and DNA Methylation
- Renal and related cancers
- Prostate Cancer Treatment and Research
- Cancer Cells and Metastasis
- Nutritional Studies and Diet
- Prostate Cancer Diagnosis and Treatment
- Immune cells in cancer
- Virus-based gene therapy research
- Urinary Bladder and Prostate Research
- Pediatric Urology and Nephrology Studies
- Cancer, Hypoxia, and Metabolism
- Kidney Stones and Urolithiasis Treatments
- Cancer, Lipids, and Metabolism
- Adrenal and Paraganglionic Tumors
- Hormonal Regulation and Hypertension
- Immune Cell Function and Interaction
Nanfang Hospital
2016-2025
Southern Medical University
2016-2025
National Natural Science Foundation of China
2013
Nanchang University
2012
Zero to Three
2009
BACKGROUNDCurrent methods for the detection and surveillance of bladder cancer (BCa) are often invasive and/or possess suboptimal sensitivity specificity, especially in early-stage, minimal, residual tumors.METHODSWe developed an efficient method, termed utMeMA, urine tumor DNA methylation at multiple genomic regions by MassARRAY. We identified BCa-specific markers combined analyses cohorts from Sun Yat-sen Memorial Hospital (SYSMH), The Cancer Genome Atlas (TCGA), Gene Expression Omnibus...
Abstract Background Regulatory B cells (Bregs), a specialized subset of that modulate immune responses and maintain tolerance in malignant tumors, have not been extensively investigated the context bladder cancer (BLCA). This study aims to elucidate roles Bregs Breg-related genes BLCA. Methods We assessed Breg infiltration levels 34 pairs BLCA corresponding paracancerous tissues using immunohistochemical staining. conducted transwell wound healing assays evaluate impact on phenotype SW780...
Abstract Aberrant expression of transforming growth factor‐β1 (TGF‐β1) is associated with renal cell carcinoma (RCC) progression by inducing cancer metastasis. However, the downstream effector(s) in TGF‐β signaling pathway not fully characterized. In present study, elevation secreted protein acidic and rich cysteine (SPARC) as a regulated gene RCC was identified applying differentially expressed analysis microarray analysis, we further confirmed this result several lines. Clinically, these...
Globally, bladder cancer is the tenth most common cancer. Mitophagy, a critical process regulating mitochondrial quantity and quality, has attracted increasing attention for its pivotal function in Nonetheless, roles underlying mechanisms are yet to be elucidated. Therefore, this study, 16 mitophagy-related genes were screened construct robust prognostic model with exceptional predictive accuracy outcomes of patients Of these genes, DARS2 was identified as key regulator that significantly...
Abstract Bladder cancer (BCa) is a prevalent malignancy with poor prognosis. SLC7A7 has been linked to BCa progression and angiogenesis, but its specific role remains unclear. We established SLC7A7-knockdown cell line investigate effects on angiogenesis. In vivo experiments assessed tumor vascularization, while in vitro studies explored exosome involvement. MiRNA sequencing identified miR-152-3p as key regulator. Further investigation using dual-luciferase reporter assays, qRT-PCR, Western...
The prevalence of primary aldosteronism is much higher than previously thought. Recent studies have shown that related to a risk cardiovascular events. However, the underlying mechanism not yet clear. Here we investigate characteristics, including inflammation, fibrosis, and adipokine expression, adipose tissues from different deposits in patients with aldosterone-producing adenoma (APA). Inflammation fibrosis changes were evaluated perirenal subcutaneous obtained APA (n = 16), normotension...
Abstract Platelets and M2 macrophages both play crucial roles in tumorigenesis, but their relationship the prognosis value of relative genes bladder cancer (BLCA) remain obscure. In present study, we found that platelets stimulated by BLCA cell lines could promote macrophage polarization, were significantly associated with infiltration samples. Through bioinformatic analyses, A2M , TGFB3 MYLK which macrophages, identified verified vitro then included predictive model. A platelet...