Lin Chen

ORCID: 0000-0003-3569-6637
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About
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Research Areas
  • Head and Neck Cancer Studies
  • Renal cell carcinoma treatment
  • Nonlinear Waves and Solitons
  • COVID-19 and healthcare impacts
  • Advanced Mathematical Physics Problems
  • Nonlinear Photonic Systems
  • Voice and Speech Disorders
  • COVID-19 Clinical Research Studies
  • Cancer-related molecular mechanisms research
  • Cancer Immunotherapy and Biomarkers
  • Obstructive Sleep Apnea Research
  • Medical Research and Treatments
  • Tracheal and airway disorders
  • MRI in cancer diagnosis
  • Cholangiocarcinoma and Gallbladder Cancer Studies
  • Cancer, Hypoxia, and Metabolism
  • Bladder and Urothelial Cancer Treatments
  • Gastric Cancer Management and Outcomes
  • Renal and related cancers
  • Long-Term Effects of COVID-19
  • Lung Cancer Treatments and Mutations
  • Head and Neck Anomalies
  • Testicular diseases and treatments
  • Airway Management and Intubation Techniques
  • Spinal Cord Injury Research

Air Force Medical University
2000-2023

Xijing Hospital
2023

Xuzhou Medical College
2023

Vanderbilt University
2002-2022

Simcere Pharmaceutical (China)
2022

Shaoxing People's Hospital
2022

Vanderbilt University Medical Center
2022

Fudan University
2010-2021

YangPu Geriatric Hospital
2021

Tongji Hospital
2021

BACKGROUNDCurrent methods for the detection and surveillance of bladder cancer (BCa) are often invasive and/or possess suboptimal sensitivity specificity, especially in early-stage, minimal, residual tumors.METHODSWe developed an efficient method, termed utMeMA, urine tumor DNA methylation at multiple genomic regions by MassARRAY. We identified BCa-specific markers combined analyses cohorts from Sun Yat-sen Memorial Hospital (SYSMH), The Cancer Genome Atlas (TCGA), Gene Expression Omnibus...

10.1172/jci139597 article EN Journal of Clinical Investigation 2020-08-20

Abstract Background The ongoing epidemics of coronavirus disease 2019 (COVID-19) have caused serious concerns about its potential adverse effects on pregnancy. There are limited data maternal and neonatal outcomes pregnant women with COVID-19 pneumonia. Methods We conducted a case-control study to compare clinical characteristics, without Results During January 24 February 29, 2020, there were sixteen confirmed pneumonia eighteen suspected cases who admitted labor in the third trimester. Two...

10.1101/2020.03.10.20033605 preprint EN medRxiv (Cold Spring Harbor Laboratory) 2020-03-13

Abstract Background Since December 2019, a novel coronavirus pneumonia (COVID-19) rapidly spread in China, reached multiple continents currently.We aimed to reveal the infectious characteristics of COVID-19 that provide more information for research coronavirus. Methods We performed retrospective study on clinical 128 cases with laboratory-confirmed from Xiangyang No 1 Hospitalad during January 2020 16 February 2020. Results Female patients account 53.1%. The aged below 20 years accounts...

10.1101/2020.02.23.20026963 preprint EN cc-by-nc-nd medRxiv (Cold Spring Harbor Laboratory) 2020-02-25

The ongoing outbreak of coronavirus disease 2019 (COVID-2019) caused by severe acute respiratory syndrome 2 (SARS-CoV-2) has been declared a pandemic the World Health Organization (WHO) and imposed large burden on global medical systems.1 Although most elective surgeries have postponed in endemic areas, patients with potentially fatal abdomen still require urgent surgical interventions (eg, those gastrointestinal perforation or purulent appendicitis) while relevant evidence is scarce....

10.1097/sla.0000000000003961 article EN Annals of Surgery 2020-04-13

The aim of this study was to explore the value contrast-enhanced ultrasound (CEUS) in differentiating small renal masses. A total 102 masses (≤ 3 cm) 99 patients were examined using conventional (CUS) and CEUS, findings reviewed evaluated comparison pathology. Significant differences between cell carcinomas (RCCs) angiomyolipomas (AMLs) noted terms orientation echogenicity on CUS (p < 0.05 for both), but location, shape, margins, homogeneity, blood flow signals RCCs color Doppler imaging...

10.5582/bst.2015.01080 article EN BioScience Trends 2015-01-01

Normal pregnancy involves extensive remodeling of uterine and spiral arteries matrix metalloproteinases (MMPs)-mediated proteolysis extracellular (ECM). Preeclampsia is characterized by hypertension in (HTN-Preg) intrauterine growth restriction (IUGR) with unclear mechanisms. Initial faulty placentation reduced perfusion pressure (RUPP) could release cytoactive factors trigger an incessant cycle suppressed trophoblast invasion arteries, further RUPP, progressive placental ischemia leading to...

10.1152/ajpheart.00602.2019 article EN AJP Heart and Circulatory Physiology 2019-12-13

Background: A proliferation-inducing ligand (APRIL) is a newly-found member in the tumor necrosis factor (TNF) superfamily. Our previous studies have already confirmed that APRIL overexpressed pancreatic cancer tumors, however, it not expressed or has weak expression normal gland tissues. Furthermore, there no report on serum patients with diseases. Herein, order to explore clinical implication of cancer, APRIL, together carcinoembryonic antigen (CEA) and carbohydrate (CA)19-9, was examined.

10.1515/cclm.2011.608 article EN Clinical Chemistry and Laboratory Medicine (CCLM) 2011-01-01

Patients with head and neck cancer (HNC) face a unique set of unmet needs. A subset these patients experience symptom control challenges related to their disease burden treatments. multidisciplinary approach involving palliative medicine is underutilized but crucial identify address concerns. There limited information on integration oncology.Case series planned data collection.Academic quaternary care center.We provide descriptive analyses HNC, including psychodiagnostic assessment validated...

10.1177/0194599820912029 article EN Otolaryngology 2020-03-17

BackgroundThere is heterogeneity in the clinical manifestations and responses to drugs RA patients due variety of factors such as genes environment. Despite advances treatment rheumatoid arthritis (RA), approximately 40% still do not achieve primary outcomes randomized trials, its low remission rate high economic consumption remain unresolved, especially developing countries. Iguratimod (IGU) a new disease-modifying anti-rheumatic drug (DMARD) with price that has demonstrated good efficacy...

10.1016/j.lanwpc.2021.100128 article EN cc-by-nc-nd The Lancet Regional Health - Western Pacific 2021-03-23

We investigate the clinicopathologic and treatment factors associated with use of postoperative radiation therapy (PORT) its effect on overall survival (OS) for patients oral cavity verrucous carcinoma (VC).Retrospective cohort study.A retrospective study National Cancer Database (NCDB) from 2006 to 2015 was performed. Multivariable logistic regression used identify independent predictive PORT. Cox Regression propensity score analyses were evaluate PORT mortality.A total 356 adult primary VC...

10.1002/lary.30009 article EN The Laryngoscope 2022-01-06

Forty-two preeclamptic patients between 36 and 41 weeks gestation were investigated for baseline fetal heart rate (FHR) variability 1 hour after the initiation of magnesium therapy, at midlabor, time delivery. With a standard regimen intravenous sulfate mean maternal serum levels three different sampling times statistically (f = 6.94, p less than 0.01 by one-way analysis variance), documenting cumulative effect continuous administration. The majority fetuses (86%) that exhibited decrease in...

10.1055/s-2007-999687 article EN American Journal of Perinatology 1988-07-01

We developed the method of cervical spinal cord decompression through durotomy followed by duroplasty and analyzed its efficacy. To develop a tactic for treatment severe injury(SCI) with extensive edema without intramedullary hematoma, to demonstrate effectiveness this method. From October 2016 January 2018, 17 operations were performed in spine patients SCI. Decompression laminectomy was done first group patients. In second group, after durotomy. A total patients, 16 males (94%) 1 female...

10.26599/jnr.2018.9040017 article EN cc-by-nc Journal of Neurorestoratology 2018-12-01
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