A5100411023- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Microfluidic and Capillary Electrophoresis Applications
- Catalytic Processes in Materials Science
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- Hepatitis B Virus Studies
- Advanced Glycation End Products research
- Catalysts for Methane Reforming
- Immunotherapy and Immune Responses
- Hepatitis C virus research
- Peroxisome Proliferator-Activated Receptors
- Metabolomics and Mass Spectrometry Studies
- Acute Myocardial Infarction Research
- Lipid metabolism and disorders
- Innovative Microfluidic and Catalytic Techniques Innovation
- Circular RNAs in diseases
- Atrial Fibrillation Management and Outcomes
- Drug Transport and Resistance Mechanisms
- Immune cells in cancer
- Catalysis and Oxidation Reactions
- Colorectal Cancer Surgical Treatments
- Glycosylation and Glycoproteins Research
- Advanced biosensing and bioanalysis techniques
- Ubiquitin and proteasome pathways
Affiliated Hospital of Nantong University
2015-2025
Zhejiang University of Science and Technology
2025
Nantong University
2014-2024
Jilin University
2024
First Hospital of Lanzhou University
2024
Second Affiliated Hospital of Nantong University
2020-2024
Nanjing Medical University
2024
Lanzhou University
2024
First Affiliated Hospital of Fujian Medical University
2024
Fujian Medical University
2024
The aim of this study is to assess if left bundle branch pacing (LBBP) can preserve physiological cardiac synchrony and deliver favorable hemodynamic effects.
The bone marrow microenvironment plays a role in myeloma cell proliferation and adhesion-mediated drug resistance. In this study, we investigated microRNA-21 (miR-21) expression changes cells that adhered to stromal (BMSCs). addition, studied the synergistic effect of miR-21 inhibition with dexamethasone (Dex), doxorubicin (Dox), or bortezomib (Bort) on survival. We found up-regulation was partially driven by nuclear factor-κB (NF-κB) signaling via adhesion BMSCs. also confirmed RhoB is...
Accumulating evidence indicates that oxidative stress and inflammation are the pathological basis of allergic diseases. Inhibition NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome could ameliorate rhinitis (AR). Here, we explored effects mechanisms underlie NLRP3 inhibition on in AR.
Progression of critically ill patients from Systemic Inflammatory Response Syndrome (SIRS) to Multiple Organ Dysfunction (MODS) accounts for more than 75% deaths in adult surgical intensive care units. Currently, there is no practical clinical technique predict the progression SIRS or MODS. In this report, we describe an NMR-based metabonomic method aid detection these conditions based on abnormal metabolic signatures. We applied pattern recognition methods analyze one-dimensional (1)H NMR...
Glioblastoma (GBM) remains one of the most challenging and lethal brain cancers, with limited treatment options. While CAR-T cells have shown promise in some patients, sustaining T-cell activity overcoming immunosuppressive tumour microenvironment (TME) remain significant hurdles. Here, we present an armoured cell design to address these challenges enhance persistence GBM tumours. We developed a highly specific humanised single-domain antibody (VHH) targeting IL13Rα2 included it alongside...
Accurate imaging of tumor hypoxia in vivo is critical for early cancer diagnosis and clinical outcomes, highlighting the great need its detection specificity sensitivity. In this report, we propose a probe (HTRNP) that simultaneously has hypoxia-targeting hypoxia-responsive capabilities to enhance efficiency. HTRNP was successfully prepared through encapsulation Pt(II)-tetrakis(pentafluorophenyl)porphyrin (PtPFPP), which exhibits hypoxia-dependent phosphorescence, within amphiphilic block...
Abstract FOXJ1 is a member of the forkhead box (FOX) family transcription factors. Recent studies suggested that may function as tumor suppressor gene in breast cancer. To investigate potential roles hepatocellular carcinoma (HCC), expression was first examined eight paired frozen HCC and adjacent noncancerous liver tissues by Western blot, we found upregulated specimens. In addition, immunohistochemistry performed to confirm our results 108 samples. Moreover, also evaluated its relation...
Background and Aims The regulation of hepatic very‐low‐density lipoprotein (VLDL) secretion is vital for lipid metabolism whose pathogenetic status involved in fatty liver disease dyslipidemia seen steatosis. Accumulated evidence suggest that apolipoprotein E (ApoE) closely related to VLDL secretion. Here, we report the expression patatin‐like phospholipase domain containing protein 7 (PNPLA7) strongly induced by steatosis positively correlates with plasma triacylglycerol (TAG) levels human...
Currently, insufficient clinical data are available to address whether low-level viremia (LLV) observed during antiviral treatment will adversely affect the outcome or strategies should be altered if LLV occurs. This study compared outcomes of patients with a maintained virological response (MVR) and who experienced their strategies.A retrospective cohort 674 chronic hepatitis B virus (HBV) infection received for more than 12 months was analyzed development end-stage liver disease follow-up...
The fatality rate for cardiovascular disease (CVD) has increased in recent years and higher levels of triglyceride have been shown to be an independent risk factor atherosclerotic CVD. Dysfunction endothelial cells (ECs) is also a key APOC3 important molecule lipid metabolism that closely associated with hyperlipidemia developing But the direct effects on ECs were still unknown. This study was aimed at determining inflammation, chemotaxis exudation ECs. ELISA, qRT-PCR, immunofluorescence,...
Plasma ceramides (Cer) have been used to evaluate risk of cardiovascular (CV) events in patients with coronary heart disease. We investigated the performance and ceramide score (CERT) hypertensive at high CV risk.Seven were analyzed using ultra-performance liquid chromatography-tandem mass spectrometry 920 essential hypertension risk, who visited Beijing Anzhen Hospital from September 2016 2018 (median age: 49 years, 562 males). All followed up for major adverse (MACE), which included...
To identify a proliferation-inducing ligand (APRIL) expression profile in tumor tissue and sputum of lung cancer, evaluate the possibility an assistant diagnosis cancer by real-time fluorescence quantitative polymerase chain reaction (RTQ-PCR) as well, authors analyzed APRIL mRNA 75 samples 71 corresponding RTQ-PCR their correlation. protein was also observed tissues Western blot immunohistochemistry. The analysis revealed elevated non-small cell (NSCLC) located membrane cytoplasm cells...
Background: A proliferation-inducing ligand (APRIL) is a newly-found member in the tumor necrosis factor (TNF) superfamily. Our previous studies have already confirmed that APRIL overexpressed pancreatic cancer tumors, however, it not expressed or has weak expression normal gland tissues. Furthermore, there no report on serum patients with diseases. Herein, order to explore clinical implication of cancer, APRIL, together carcinoembryonic antigen (CEA) and carbohydrate (CA)19-9, was examined.