A5100399175- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Lung Cancer Research Studies
- Colorectal Cancer Treatments and Studies
- Cancer-related molecular mechanisms research
- Peptidase Inhibition and Analysis
- Gastric Cancer Management and Outcomes
- Cancer, Hypoxia, and Metabolism
- Protein Kinase Regulation and GTPase Signaling
- Glycosylation and Glycoproteins Research
- Epigenetics and DNA Methylation
- Synthesis and biological activity
- Melanoma and MAPK Pathways
- Ubiquitin and proteasome pathways
- Angiogenesis and VEGF in Cancer
- MicroRNA in disease regulation
- Galectins and Cancer Biology
- FOXO transcription factor regulation
- Advanced Proteomics Techniques and Applications
- Advanced biosensing and bioanalysis techniques
- Ferroptosis and cancer prognosis
- Protein Degradation and Inhibitors
- Medicinal Plant Pharmacodynamics Research
- Drug Transport and Resistance Mechanisms
- Circular RNAs in diseases
National University of Singapore
2025
Tianjin Medical University Cancer Institute and Hospital
2010-2024
Peking University Shenzhen Hospital
2024
National Clinical Research
2020-2023
Nanjing University
2021
First Affiliated Hospital of Anhui Medical University
2020
Anhui Medical University
2020
Chengdu Research Base of Giant Panda Breeding
2019
Nantong University
2011-2012
Affiliated Hospital of Nantong University
2012
Abstract Epidermal growth factor (EGF) mediates breast cancer cell chemotaxis and metastasis through mechanisms that involve the growth-regulatory mammalian target of rapamycin (mTOR) complex mTORC2, but involved remain obscure. Here, we report rapamycin-insensitive mTORC2 component protein Rictor is a critical mediator in cells. In patients with ductal carcinoma, expression was associated increased lymph node metastasis. EGF induced translocation colocalization kinase Cζ (PKCζ), pivotal...
Growing evidence suggests that reactive oxygen species such as hydrogen peroxide (H(2)O(2)) can function important signaling molecules in vascular cells. H(2)O(2)-activated redox-sensitive pathways mediate both physiological and pathological responses given the location concentration of H(2)O(2). We showed previously for first time calcium/calmodulin-dependent protein kinase II (CaMKII) is endothelial cells, mediating H(2)O(2) upregulation nitric oxide synthase. This response always...
Some studies have reported that activated ribosomes are positively associated with malignant tumors, especially in hepatocellular carcinoma (HCC). The RNA-binding protein PNO1 is a critical ribosome rarely human tumors. This study aimed to explore the molecular mechanisms of HCC. Using 150 formalin-fixed and paraffin-embedded samples 8 fresh samples, we found high expression HCC tumor tissues through Western blotting RT-PCR. Moreover, higher was poor prognosis patients. In vitro vivo...
Metastasis and chemoresistance are major causes of poor prognosis in patients with esophageal squamous cell carcinoma (ESCC), manipulated by multiple factors including deubiquitinating enzyme (DUB). DUB PSMD14 is reported to be a promising therapeutic target various cancers. Here, we explored the antitumor activity Thiolutin (THL), inhibitor, as new therapy strategy ESCC. Methods: Through 4-NQO-induced murine ESCC model, investigated expression tumorigenesis. Ubiquitin-AMC assay was...
Targeted covalent inhibitors (TCIs) play an essential role in the fields of kinase research and drug discovery. Most existing TCIs are however cysteine‐ or lysine‐reactive, thus severely limiting their potential applications. New types capable covalently targeting other nucleophilic amino acids that readily available proteins urgently needed. We report herein a glyoxal‐based, arginine‐reactive strategy to generate potent selective small‐molecule Mcl‐1 (an important anti‐apoptotic protein) by...
Abstract Many studies have shown that the hyperactivation of ribosome biogenesis plays essential roles in initiation and progression cancers. As a assembly factor, PNO1 an important role biogenesis. However, little is known about expression function human tumors. In our present study, we aimed to explore functional underlying molecular mechanisms lung adenocarcinoma (LUAD). Both bioinformatics databases tumor tissues demonstrated LUAD was higher than adjacent predicted poor survival...
Abstract FOXJ1 is a member of the forkhead box (FOX) family transcription factors. Recent studies suggested that may function as tumor suppressor gene in breast cancer. To investigate potential roles hepatocellular carcinoma (HCC), expression was first examined eight paired frozen HCC and adjacent noncancerous liver tissues by Western blot, we found upregulated specimens. In addition, immunohistochemistry performed to confirm our results 108 samples. Moreover, also evaluated its relation...
Ubiquitination is a reversible process that not only controls protein synthesis and degradation, but also essential for transport, localization biological activity. Deubiquitinating enzyme (DUB) dysfunction leads to various diseases, including cancer. In this study, we aimed explore the functions mechanisms of crucial DUBs in head neck squamous cell carcinoma (HNSCC). Based on bioinformatic analysis immunohistochemistry detection, YOD1 was identified be significantly downregulated HNSCC...
Numerous studies have reported the regulatory effects of miR-21-5p and reversine in human breast cancer (HBC). However, mechanism has not been fully investigated HBC. The aim current study was to assess action reversine, with or without miR-21-5p, HBC progression. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) Western blot results confirmed upregulation downregulation sprouty RTK signaling antagonist 2 (SPRY2) Bioinformatics analysis luciferase assay identified...
Perbenzoylated sialooligosaccharides were found to be stable derivatives, giving intense signals during the matrix-assisted laser desorption/ionization (MALDI) mass spectrometric analysis in positive-ion mode. Terminal Neu5NAcα2→3 and α2→6Gal units of oligosaccharides undergo characteristic structural changes benzoylation, yielding easily recognizable spectral patterns. Subpicomole carbohydrate samples successfully benzoylated analyzed through MALDI spectrometry.
Phospholipase C-γ1 (PLC-γ1) hydrolyzes phosphatidylinositol 4,5-bisphosphate to the second messengers inositol 1,4,5-trisphosphate and diacylglycerol (DAG). PLC-γ1 is implicated in a variety of cellular signalings processes including mitogenesis calcium entry. However, numerous studies demonstrate that lipase activity not required for mediate these events. Here, we report phospholipase plays an essential role nerve growth factor (NGF)-triggered Raf/MEK/MAPK pathway activation PC12 cells....
There is evidence that probiotics have a broad antitumor effect in colorectal cancer (CRC). However, the mechanism remains obscure. Here, we investigated of Bornlisy (BO)-cocktails three on colitis-associated colon (CAC) and underlying mechanism. The treatment CAC mice with BO resulted decreased tumor loads as compared their counterparts. also inhibited proliferation metastasis CRC cells vitro. Furthermore, cell through downregulating glycolysis. Activating glycolysis reversed protective...
Heat shock proteins (HSPs) are a group of highly conserved found in wide range organisms. In recent years, members the HSP family were overexpressed various tumors and widely involved oncogenesis, tumor development, therapeutic resistance. our previous study, DNAJC24, member DNAJ/HSP40 HSPs, was to be closely associated with malignant phenotype hepatocellular carcinoma. However, its relationship other malignancies needs further explored. Herein, we demonstrated that DNAJC24 exhibited...
Metastasis is a major cause of mortality among lung cancer patients. In previous high-throughput screening 20,000 compounds to identify inhibitors cell migration, 4-methyl-3-nitrobenzoic acid was found inhibit the migration nine tumor lines. The present study used human non-small (NSCLC) treatment with significantly inhibited epithelial growth factor (EGF)-induced chemotaxis and chemokinesis cells in NSCLC cells. defect likely due impairment EGF-induced cofilin phosphorylation actin...