A5021078477- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Minerals Flotation and Separation Techniques
- Diet and metabolism studies
- Bariatric Surgery and Outcomes
- Gut microbiota and health
- Lung Cancer Treatments and Mutations
- Fibroblast Growth Factor Research
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Cancer-related gene regulation
- Mechanisms of cancer metastasis
- Neuroendocrine Tumor Research Advances
- Ubiquitin and proteasome pathways
- Cancer Mechanisms and Therapy
- Cancer, Lipids, and Metabolism
- Traditional Chinese Medicine Analysis
- Cancer-related Molecular Pathways
- Geoscience and Mining Technology
- Cancer Cells and Metastasis
- TGF-β signaling in diseases
- Acupuncture Treatment Research Studies
- Immune Cell Function and Interaction
- Plant-based Medicinal Research
Second Military Medical University
2014-2025
Changhai Hospital
2014-2025
Zhejiang Chinese Medical University
2024-2025
First Affiliated Hospital of Xinxiang Medical University
2015-2025
China Pharmaceutical University
2025
Central Hospital of Zibo
2025
Community Health Center
2025
Second Hospital of Shandong University
2025
First Hospital of Shanxi Medical University
2025
Shanxi Medical University
2023-2025
Fibroblast growth factor (FGF)-1 mitogenic signal transduction is mediated in part by gene products that are specifically expressed response to cell surface receptor binding and activation. We have used a targeted differential display method identify FGF-1-inducible genes murine NIH 3T3 fibroblasts. Here we report one of these predicted encode novel serine/threonine-specific protein kinase. This putative kinase has been named Fnk, for FGF-inducible The deduced Fnk amino acid sequence 49, 36,...
The binding of polypeptide growth factors to their appropriate cell surface transmembrane receptors triggers numerous biochemical responses, including the transcriptional activation specific genes. We have used a differential display approach identify fibroblast factor-1-inducible genes in murine NIH 3T3 cells. Here, we report that factor-inducible-14 (Fn14) gene is factor-regulated, immediate-early response expressed developmental stage- and adult tissue-specific manner <i>in vivo</i>. This...
// Ben Liu 1, * , Jinli Qu Fangxiu Xu 1 Yan Guo Yu Wang Herbert 2 Biyun Qian 3 Department of Epidemiology and Biostatistics, Key Laboratory Breast Cancer Prevention Therapy, Ministry Education, Tianjin, National Clinical Research Center Cancer, Tianjin Medical University Institute Hospital, 300060, China Program, Hawaii Center, Honolulu, HI 96813, USA Hongqiao International Medicine, Shanghai Tongren Hospital Faculty Public Health, Jiao Tong School 200025, These authors have contributed...
Our aim was to investigate whether microRNAs can predict the clinical outcome of patients with gastric cancer. We used integrated analysis microRNA and mRNA expression profiles identify cancer subtypes their underlying regulatory scenarios.MicroRNA-based were identified by consensus clustering 90 tissues. Activated pathways in gene profiles. Further conducted model a network for each subtype. RNA protein analyzed RT-PCR tissue microarray, respectively, cohort 385 cases (including profiling)...
// Xinyuan Xu 1, * , Jianying Li Xiang Sun 2, Yan Guo Dake Chu 3 Wei 4 Xia 1 Guodong Yang Xinping Liu Libo Yao Jian Zhang Lan Shen The State Key Laboratory of Cancer Biology, Department Biochemistry and Molecular Fourth Military Medical University, Xi'an, Shaanxi, China 2 Prosthodontics, School Stomatology, Gastrointestinal Surgery, Xijing Hospital Digestive Diseases, Obstetrics Gynecology, Hospital, These authors have contributed equally to this work Correspondence to: Zhang, e-mail:...
Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide and third cancer in Asia. HCC has heterogeneous etiologic molecular profiles a varied response to therapeutics. The high recurrence rate curtailed survival this are attributed its resistance therapy. ultimate goal develop more effective personalized therapeutic strategy for HCC, but first step system classifying disease on basis of biomarkers. To that end, we performed mRNA microRNA (miRNA) expression profiling 100...
Abstract Recent work with gut microbiota after bariatric surgery is limited, and the results have not been in agreement. Given role of regulating host metabolism, we explored effect Roux‐en‐Y gastric bypass (RYGB) sleeve gastrectomy (SG) on modifications regard to potential influence food intake and/or weight loss examined their links metabolism. Zucker diabetic fatty rats were divided into following groups: RYGB; sham‐operated pair‐fed as fed ad libitum ; SG. The metabolic effects profile...
Dysbiosis of gut microbiota impairs the homeostasis immune and metabolic systems. Although previous studies have revealed correlation between various diseases, function diabetic nephropathy (DN) has not been discovered distinctly. In this study, we tried to investigate profile in DN.A total 100 people were enrolled study. Twenty healthy people, 20 diabetes patients, 60 DN patients. The patients divided into three stages including stage III, IV, V. We conducted taxonomic analyses different...
Backgrounds Diabetes nephropathy (DN) is a growing public health concern worldwide. Renal dysfunction impairment in DN intimately linked to ER stress and its related signaling pathways. Nonetheless, the underlying mechanism biomarkers for this function of remain unknown. Methods Microarray datasets were retrieved from Gene Expression Omnibus (GEO) database, stress-related genes (ERSRGs) downloaded MSigDB GeneCards database. We identified hub ERSRGs progression by intersecting with...
The aim of the study was to determine occurrence and risk factors diabetes mellitus (DM) in Chinese patients with chronic pancreatitis (CP), particular emphasis on those endoscopic or surgical therapy for CP.Four hundred forty-five contacted CP our hospital between January 1, 1997, July 31, 2007, were followed up. Risk DM determined a multivariate analysis after exclusion 58 patients.The cumulative rate 51.5% (SD, 8%) at 20 years onset 27.8% 6%) 10 endotherapy surgery, without significant...
Tamoxifen, an endocrine therapy drug used to treat breast cancer, is designed interrupt estrogen signaling by blocking the receptor (ER). However, many ER-positive patients are low reactive or resistant tamoxifen. Metformin a widely anti-diabetic with noteworthy anti-cancer effects. We investigated whether metformin has additive effects tamoxifen in cancer therapy. The efficacy of alone and combination against was analyzed cell survival, DNA replication activity, plate colony formation,...
The tumor suppressor gene PTEN is one of the most often deleted genes in human prostate cancer. Loss an important event carcinogenesis. Metabolic reprogramming induced by loss fuels malignant growth and proliferation cancer cells. Targeted metabolomics analysis was used to investigate effects on intracellular metabolic pathways DU-145 cells were transfected with siRNAs (siRNA-1 siRNA-2) for 48 h, endogenous expression monitored western blotting. Changes metabolites determined liquid...
The Warburg effect is one of the important hallmarks cancer.The activation oncogene and inactivation tumor suppressor gene contribute to enhancement glycolytic enzymes effect.The N-myc downstream regulated 2 (NDRG2) a frequently lost in various types cancer.However, little known about function therapeutic value NDRG2 hepatocellular carcinoma (HCC).In this study, we found that lactate dehydrogenase A (LDHA) were aberrantly expressed HCC closely related correlation between LDHA expression...
Abstract The protein methyltransferase SET and MYND domain-containing 2 (SMYD2) is a transcriptional regulator that methylates histones nonhistone proteins. As an oncogene, SMYD2 has been investigated in numerous types of cancer. However, its involvement lung cancer remains elusive. prognostic value expression adenocarcinoma (LUAD) was determined through bioinformatics analysis, reverse-transcription polymerase chain reaction, western blotting, immunohistochemistry. effect on LUAD cell...
Abstract Sialic acid-binding immunoglobulin-like lectin 15 (Siglec-15) is an immune checkpoint molecule with sequence homology to programmed cell death ligand 1 (PD-L1), which mainly expressed on macrophages and tumor cells. However, whether Siglec-15-induced immunosuppression poor prognosis are independent of PD-L1 remains unclear. In this study, we collected samples 135 non-small lung cancers found that Siglec-15 expression were in cancer by multiple immunofluorescence staining....
Autism is a pervasive neurodevelopmental disorder,thought to be caused by combination of genetic heritability and environmental risk factors. Some autistic-like traits have been reported in mothers autistic children. We hypothesized that dysregulation oxytocin (OXT), Arg-vasopressin (AVP) sex hormones, found children, may also exist their mothers.We determined plasma levels OXT (40 autism vs. 26 control group), AVP 17) hormones (61 47) normal children enzyme immunoassay radioimmunoassay,...