A5100439852- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Breast Cancer Treatment Studies
- Ferroptosis and cancer prognosis
- Digestive system and related health
- Cancer Cells and Metastasis
- RNA Research and Splicing
- Breast Implant and Reconstruction
- Autophagy in Disease and Therapy
- RNA regulation and disease
- Nanoplatforms for cancer theranostics
- Animal Genetics and Reproduction
- TGF-β signaling in diseases
- Helicobacter pylori-related gastroenterology studies
- Diet and metabolism studies
- Immune cells in cancer
- Drug-Induced Hepatotoxicity and Protection
- Global Cancer Incidence and Screening
- Seed and Plant Biochemistry
- Hippo pathway signaling and YAP/TAZ
- Dietary Effects on Health
Northwest A&F University
2025
Wuhan Polytechnic University
2021-2024
Hebei Agricultural University
2022
Fudan University Shanghai Cancer Center
2022
Zhengzhou University
2017-2022
Affiliated Hospital of Nantong University
2021
Nantong University
2021
Second Affiliated Hospital of Nantong University
2021
Third Affiliated Hospital of Sun Yat-sen University
2017-2020
Sun Yat-sen University
2017-2020
Abstract The abnormal expression of long noncoding RNAs (lncRNAs) plays an important role in the regulation human cancer progression and drug resistance. lncRNA OPI5‐AS1 is a crucial regulator some cancers; however, its cisplatin resistance osteosarcoma remains unclear. We found that OIP5‐AS1 was significantly upregulated cisplatin‐resistant (CR) cells MG63‐CR SaOS2‐CR compared with corresponding parental cells. silencing suppressed cell growth vitro vivo, promoted apoptosis cells,...
Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide and third cancer in Asia. HCC has heterogeneous etiologic molecular profiles a varied response to therapeutics. The high recurrence rate curtailed survival this are attributed its resistance therapy. ultimate goal develop more effective personalized therapeutic strategy for HCC, but first step system classifying disease on basis of biomarkers. To that end, we performed mRNA microRNA (miRNA) expression profiling 100...
// Ping Chen 1, 2 , Jing-Yang Zhang Bei-Bei Sha Yan-Er Ma Tao Hu Yang-Cheng Hao Sun 3 Jian-Xiang Shi Zi-Ming Dong Pei Li 1 Cancer Chemoprevention Collaborative Innovation Center in Henan Province, Zhengzhou University, Zhengzhou, Henan, 450001, China Department of Pathophysiology, College Basic Medical Sciences, Public Health, Key Laboratory for Tumor Epidemiology, Affiliated Hospital, Correspondence to: Li, email: lipeifreemai@zzu.edu.cn Dong, Dongzm@zzu.edu.cn Shi, jianxiangshi@zzu.edu.cn...
Regulation of cancer angiogenesis could be a useful strategy in therapy. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is long non-coding RNA (lncRNA), and can induce cell proliferation, while lncRNAs, generally are able to act as microRNA (miRNA) sponges. The latter type competitive endogenous (ceRNA) that regulates expression the targeting miRNAs protein-coding genes. This study investigated proliferative role MALAT1 human umbilical vein endothelial cells (HUVECs)...
MicroRNAs (miRs) play important roles in cancer. MiR-936 has been reported to suppress glioma and non-small cell lung cancer proliferation invasion. However, the role of miR-936 laryngeal squamous carcinoma (LSCC) is still unknown. In our present study, we have demonstrated that was significantly downregulated LSCC tissues compared with adjacent normal tissues. Furthermore, overexpression inhibited proliferation, migration, invasion drug resistance cells. Moreover, could improve sensitivity...
Long noncoding RNAs (lncRNAs) play critical roles in carcinoma occurrence and metastasis. LINC00941 has been found to mediate the development of gastric cancer, was negatively associated with longer overall survival lung adenocarcinoma patients. Herein, our aim investigate effects mechanisms NSCLC progression. Microarray used identify change lncRNAs NSCLC, increase tumor tissues patients’ plasma. Knockdown didn’t modulate proliferation cells, but inhibition cells suppressed angiogenesis...
The objective of this study was to detect the effect NADPH oxidase (NOX) inhibition on metastasis lung cancer. Primary human cancer cells were isolated from surgical tissues using Cancer Cell Isolation Kit. Invasion detected BD Biocoat Matrigel Chamber assay. Expressions microRNA-21 (miR-21), PTEN, MMP9, and p47 by qPCR. Groups nude mice challenged with A549 or without DPI for tumor survival. NOX in significantly reduced their invasive potential vitro. vivo led decreased prolonged survival...
Abstract The burgeoning functions of many microRNAs (miRs) have been well study in cancer. However, the level and function miR-1205 laryngeal squamous cell cancer remains unknown. In current research, we validated that was notably downregulated human carcinoma (LSCC) samples comparison with tissues adjacent to LSCC, correlated T stage, lymph node metastasis, clinical stage. Using Kaplan–Meier analysis indicates high expression has a favorable prognosis for patients LSCC. Functional assays...
OBJECTIVES: PFKFB3 regulates glycolysis in tumor cells, might function as an oncogene, and is associated with cancer metastasis. However, its role gastric (GC) remains largely unknown. METHODS: expression was assessed by immunohistochemistry (IHC) GC tissues paired paracancerous histological normal (PCHNTs). The associations of clinical features HIF-1α, Ki-67, E-cadherin, Snail, Vimentin levels were assessed. A series vivo vitro experiments performed to investigate the effects on growth,...
Abstract Background Emerging evidence suggested that long intergenic noncoding RNA (lincRNA) 00887 (NR_024480) reduced the invasion and metastasis of non-small cell lung cancer by sponging miRNAs degradation. However, role regulatory mechanism linc00887 in progression cervical remain largely unknown. Methods In vivo or vitro, RT-qPCR assay was used to detect expression human normal (N = 30), tissues epithelial cells (Ect1/E6E7) lines (HeLa, C33A). Then, CCK-8 Transwell assays were examine...
Compared with older patients, young women breast cancer (YWBCs) have a poorer prognosis and higher risk of recurrence. Ages ≤35 years are independent factors for local recurrence cancer. Surgery is the most important treatment YWBC, there still lack prospective studies comparing surgical options survival. We retrospectively compared effects on disease-free survival (DFS) overall (OS) YWBC at Fudan University Shanghai Cancer Center (FUSCC).
The incorporation of cereals in yogurt has recently gained increasing consumer approval, for its high nutritional value and health benefits, all over the world. Following this emerging trend, Tartary buckwheat (TB) was supplemented into as a natural functional ingredient order to develop with enhanced product characteristics acceptability. impact TB addition on physicochemical properties (pH, acidity, apparent viscosity, etc.) viability lactic acid bacteria investigated. It is found that...
Scope Proliferation and differentiation of intestinal stem cells (ISCs) are crucial for functional restoration after injury, which can be regulated by nutritional molecules. Aspartate is implicated in maintaining barrier but underlying mechanisms remain elusive. Here, this study seeks to investigate if aspartate alleviates colonic epithelial damage regulating ISC function, elucidate its mechanisms. Methods results Eight‐week‐old male C57BL/6 mice supplement with or without 1% L‐aspartate...
The aim is to study the role of miR-675-5p coded by long non-coding RNA H19 in development Nasopharyngeal Cancer (NPC) and whether regulates invasion metastasis NPC through targeting SFN (14-3-3σ). further validated relationship between H19, their with NPC. Western blot was used detect expression 14-3-3σ protein immortalized normal nasopharyngeal epithelial cells NP69 different metastatic potential cells, 6-10B 5-8F. At same time, find out miR-675-5p, nasopharynx varied carcinoma 5-8F were...
The beneficial effects of glycine were tested in piglets with diquat-induced hepatic injury.Thirty-two assigned by a 2×2 factorial experimental design including supplementation and diquat challenge. After 3 weeks feeding basic diet or 1% supplemented diet, challenged saline. 1 week later, the slaughtered samples collected.Our results indicated that alleviated induced morphological injury, decreased activities plasma alanine aminotransferase, aspartate aminotransferase glutamyl transpeptidase...
It has been proved that polyphenols have positive effects against inflammatory response and oxidative stress. We investigated whether dietary supplementation of the holly (HP) might relieve a liver injury induced by lipopolysaccharide (LPS) in weaned pigs. Twenty-four pigs were fed diets containing 0 or HP saline LPS challenge 2×2 factorial arrangement treatments. On d 17, intraperitoneally injected with an saline. Dietary reduced plasma AST GGT activities MDA levels, increased ALB TP GSH...