A5082744746- Spine and Intervertebral Disc Pathology
- MicroRNA in disease regulation
- Cell Adhesion Molecules Research
- Electrospun Nanofibers in Biomedical Applications
- Musculoskeletal pain and rehabilitation
- interferon and immune responses
- Shoulder Injury and Treatment
- Cancer-related molecular mechanisms research
- Pancreatic and Hepatic Oncology Research
- RNA Research and Splicing
- Tendon Structure and Treatment
- Angiogenesis and VEGF in Cancer
- Immunotherapy and Immune Responses
- Circular RNAs in diseases
- Mesenchymal stem cell research
- Bone Metabolism and Diseases
- Gallbladder and Bile Duct Disorders
- Metabolism, Diabetes, and Cancer
- Wound Healing and Treatments
- Cardiac Imaging and Diagnostics
- PI3K/AKT/mTOR signaling in cancer
- Central Venous Catheters and Hemodialysis
- Ocular Diseases and Behçet’s Syndrome
- RNA modifications and cancer
- Sphingolipid Metabolism and Signaling
Dalian Medical University
2014-2025
First Affiliated Hospital of Dalian Medical University
2025
Ningbo Institute of Industrial Technology
2025
Chinese Academy of Sciences
2025
Army Medical University
2015-2024
Southwest Hospital
2013-2024
Sichuan Agricultural University
2024
Qingdao University
2015-2024
Affiliated Hospital of Qingdao University
2018-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2010-2024
Tissue engineering techniques using novel scaffolding materials offer potential alternatives for managing tendon disorders. An ideal tissue engineered scaffold should mimic the three-dimensional (3D) structure of natural extracellular matrix (ECM) native tendon. Here, we propose a electrospun nanoyarn network that is morphologically and structurally similar to ECM tissues. The nanoyarn, random nanofiber, aligned nanofiber scaffolds synthetic biodegradable polymer,...
Abstract Stem cells are promising for the treatment of myocardial infarction (MI) and large animal models should be used to better understand full spectrum stem cell actions preclinical evidences. In this study, bone marrow mesenchymal (BM-MSCs) were transplanted into swine heart ischemia model. To detect glucose metabolism in global left ventricular myocardium regional myocardium, combined with assessment cardiac function, positron emission tomography-computer tomography (PET-CT) magnetic...
Accumulating literatures have indicated that long non-coding RNAs (lncRNAs) are potential biomarkers play key roles in tumor development and progression. Urothelial cancer associated 1 (UCA1) is a novel lncRNA acts as biomarker involved the of cancers. However, molecular mechanism UCA1 renal still needed to further explore.The relative expression level was determined by Real-Time qPCR total 88 patients with urothelial different cell lines. Loss-of-function experiments were performed...
Abstract The abnormal expression of long noncoding RNAs (lncRNAs) plays an important role in the regulation human cancer progression and drug resistance. lncRNA OPI5‐AS1 is a crucial regulator some cancers; however, its cisplatin resistance osteosarcoma remains unclear. We found that OIP5‐AS1 was significantly upregulated cisplatin‐resistant (CR) cells MG63‐CR SaOS2‐CR compared with corresponding parental cells. silencing suppressed cell growth vitro vivo, promoted apoptosis cells,...
The multi‑kinase inhibitor sorafenib is the only drug for which randomized control trials have shown improved patient survival in advanced hepatocellular carcinoma (HCC). However, life expectancy extended these cases by a few months. anti‑type II diabetes agent metformin was used this study an effort to find more efficient approach HCC treatment. Sorafenib effectively reversed activation status of mTORC2 induced and enhanced suppression mTORC1 MAPK pathway cells, may be responsible reduced...
Abstract Premature senescence of nucleus pulposus (NP) cells and inflammation are two common features degenerated discs. This study investigated the effects inflammatory cytokine TNF-α on premature NP molecular mechanism behind this process. Rat were cultured with or without different concentrations for 1 3 days. The inhibitor LY294002 was used to determine role PI3K/Akt pathway. that incubated days followed by recovery in control medium analyze cellular senescence. Results showed promoted...
Central venous catheters (CVCs) have been an effective access for chemotherapy instead of peripherally intravenous catheters. There were limited studies on the choices and effects different types CVCs chemotherapy. The aim this study was to compare complications, cost, patients' quality life satisfaction three commonly used chemotherapy, such as implanted port, inserted central (PICCs), external non-tunneled (NTCs).A double-center prospective cohort carried out from March 2014 December 2016....
// Chunhong Cao 1, * , Deguang Sun Liang Zhang 1 Lei Song Department of General Surgery, The Second Affiliated Hospital Dalian Medical University, Dalian, 116027 Liaoning, China These authors have contributed equally to this work as the co-first author Correspondence to: Zhang, email: zhangliangdlmu@163.com Song, songleidlmu@163.com Keywords: miR-186, Twist1, GC Received: September 12, 2016 Accepted: October 17, Published: November 07, ABSTRACT Recent evidence shows that miRNAs are...
To compare the long-term symptom alleviation and re-intervention of high-intensity focused ultrasound (HIFU) ablation secondary myomectomy for women with recurrent symptomatic uterine fibroids following myomectomy.A retrospective analysis.A general hospital in China.One hundred eighty-eight myomectomy.Women who underwent HIFU (n = 101) 87) at Chinese PLA General Hospital from January 2008 to December 2016 were analysed. Symptom relief recurrence evaluated using transformed severity scale...
This study introduces a novel 3D scaffold for bone regeneration, composed of silk fibroin, chitosan, nano-hydroxyapatite, LL-37 antimicrobial peptide, and pamidronate. The addresses critical need in tissue engineering by simultaneously combating infections promoting growth. was incorporated its broad-spectrum properties, while pamidronate included to inhibit resorption. scaffold's porous structure, essential cell infiltration nutrient diffusion, achieved through freeze-drying process. In...
Purpose Acute Mesenteric Ischemia (AMI) is a critical condition marked by restricted blood flow to the intestine, which can lead tissue necrosis and fatal outcomes. We aimed develop deep learning (DL) model based on CT angiography (CTA) imaging clinical data diagnose AMI. Methods A retrospective study was conducted 228 patients suspected of AMI, divided into training test sets. Clinical (medical history laboratory indicators) included in multivariate logistic regression analysis identify...
The treatment of infected wounds is often complicated by bacterial infection and impaired scar healing. Antibiotics growth factors are typically utilized to address these clinical challenges expedite wound However, the use hydrogels containing therapeutic agents restricted complex cases increases costs considerably. In this study, we developed a quaternized-chitosan-based hybrid hydrogel dressing (SQFB) with intrinsic antibacterial properties limitations. contained interpenetrating polymer...
BACKGROUND Single-port laparoscopic appendectomy is an advanced minimally invasive surgery that involves the use of upgraded instruments and equipment. We previously modified single-port with needle-type grasping forceps (mSLAN) for patients simple appendicitis, but feasibility safety our procedure need further evaluation in a high-quality clinical study. AIM To compare short-term outcomes mSLAN those conventional three-port (CLA) acute uncomplicated appendicitis. METHODS This single-center,...
Mechanical overloading can lead to disc degeneration. Nucleus pulposus (NP) cell senescence is aggravated within the degenerated disc. This study was designed investigate effects of high compression on NP and underlying molecular mechanism this process. Rat cells seeded in decalcified bone matrix were subjected non-compression (control) or (2% 20% deformation, 1.0 Hz, 6 hours/day). The reactive oxygen species (ROS) scavenger N-acetylcysteine (NAC) p38 MAPK inhibitor SB203580 used roles ROS...