A5100332363- Breast Cancer Treatment Studies
- Advanced Breast Cancer Therapies
- HER2/EGFR in Cancer Research
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- AI in cancer detection
- Breast Lesions and Carcinomas
- Radiomics and Machine Learning in Medical Imaging
- Microbial Natural Products and Biosynthesis
- Cancer Treatment and Pharmacology
- Cancer-related Molecular Pathways
- Antifungal resistance and susceptibility
- MRI in cancer diagnosis
- Erythrocyte Function and Pathophysiology
- SARS-CoV-2 and COVID-19 Research
- Global Cancer Incidence and Screening
- Microbial metabolism and enzyme function
- Fermentation and Sensory Analysis
- Virology and Viral Diseases
- Tendon Structure and Treatment
- Genomics and Phylogenetic Studies
- BRCA gene mutations in cancer
- Microbial Metabolism and Applications
- Fungal Infections and Studies
Sun Yat-sen Memorial Hospital
2017-2025
Sun Yat-sen University
2017-2025
Guangdong Medical College
2024
Sun Yat-sen University Cancer Center
2022
State Key Laboratory of Oncology in South China
2022
Zhengzhou University
2021-2022
Education Department of Heilongjiang Province
2021
Ministry of Agriculture and Rural Affairs
2021
Northeast Agricultural University
2021
Zhejiang Gongshang University
2011-2020
Due to the adverse effects of erythropoietin (EPO) on cancer patient survival, it is necessary develop new agents that can be used efficiently manage and treat cancer-related anemia. In this study, novel distinctive carbon dots, J-CDs, derived from jujube are designed, synthesized, characterized. Based obtained results, material comprises sp2 sp3 atoms, as well oxygen/nitrogen-based groups, specifically promotes proliferation erythroid cells by stimulating self-renewal progenitor in vitro...
Tamoxifen resistance is accountable for relapse in many ER-positive breast cancer patients. Most of these recurrent patients receive chemotherapy, but their chemosensitivity unknown. Here, we report that tamoxifen-resistant cells express significantly more BARD1 and BRCA1, leading to DNA-damaging chemotherapy including cisplatin adriamycin, not paclitaxel. Silencing or BRCA1 expression inhibition phosphorylation by Dinaciclib restores the sensitivity cells. Furthermore, show activated...
The prognostic value of pathological complete response (pCR) in HR+/HER2- breast cancer patients following neoadjuvant chemotherapy (NAC) is limited, as many these achieve long-term survival regardless pCR status. effectiveness current tools-residual burden (RCB), the Miller-Payne (MP) score, CPS-EG score and immunohistochemical 4 (IHC4)-in this subgroup remains uncertain. In study, we validated role approaches developed a COMBINED capable more accurately stratifying into distinct risk...
Early Triple negative breast cancer (eTNBC) is the subtype with worst outcome. Circulating tumor DNA (ctDNA) shown to predict prognosis of cancer, but its utility in eTNBC remains unclear. 130 stage II-III female patients receiving neoadjuvant chemotherapy (NAC) have been enrolled prospectively and subjected ctDNA analysis. at post-NAC (pre-surgery) post-surgery, not baseline, associated worse prognosis. A threshold 1.1% maximum variant allele frequency baseline stratifies different relapse...
Different loading regimens of cyclic tensile strain impose different effects on cell proliferation and tenogenic differentiation TDSCs in three-dimensional (3D) culture vitro, which has been little reported previous literatures. In this study we assessed the efficacy a poly(L-lactide-co- ε -caprolactone)/collagen (P(LLA-CL)/Col) scaffold under mechanical stimulation custom-designed 3D bioreactor, revealed that with frequencies (0.3 Hz, 0.5 1.0 Hz) amplitudes (2%, 4%, 8%) had no influence...
Background The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Wuhan, China, rapidly grew into a global pandemic. How SARS-CoV-2 evolved remains unclear. Methods We performed comprehensive analysis using the available genomes and its closely related coronaviruses. Results ratio nucleotide substitutions to amino acid spike gene (9.07) between WIV04 Bat-CoV RaTG13 was markedly higher than that other coronaviruses (range, 1.29–4.81); non-synonymous synonymous...
Responses to extracellular stress are required for microbes survive in changing environments. Although the response mechanisms have been characterized extensively, evolution of pathway remains poorly understood. Here, we studied High Osmolarity Glycerol (HOG) pathway, one important osmotic pathways, across 10 yeast species and underpinned evolutionary forces acting on evolution.Although HOG is well conserved surveyed species, rate genes this varied substantially among or within different...
One of the main objectives broiler breeding is to prevent excessive abdominal adipose deposition. The role RNA modification in deposition not clear. This study was aimed map m 6 A landscape chicken tissue. MeRIP-seq performed compare differences methylation pattern between fat and lean broilers. We found that start codons, stop coding regions, 3′-untranslated regions were generally enriched for peaks. high methylated genes (fat birds vs. birds) primarily associated with fatty acid...
Breast cancer is the most commonly diagnosed in women, and has become second leading cause of death among women worldwide. Chemoresistance an important problem breast clinics. The identification new mechanisms affecting chemosensitivity great clinical value for treatment cancer. expression levels chemoresistance-associated long non-coding RNA (CRALA), a newly discovered RNA, were measured by quantitative real time-PCR 79 pre-treatment biopsied primary samples. Small interfering RNAs used to...
Acetobacter pasteurianus, an acetic acid resistant bacterium belonging to alpha-proteobacteria, has been widely used produce vinegar in the food industry. To understand mechanism of its high tolerance and robust ability oxidizing ethanol (> 12%, w/v), we described 3.1 Mb complete genome sequence (including 0.28 M plasmid sequence) with a G+C content 52.4% A. pasteurianus Ab3, which was isolated from traditional Chinese rice (Meiguichu) fermentation process. Automatic annotation revealed...
In order to obtain high-level production of antibiotics, oils have been used as the main carbon source for some Streptomyces strains. Based on multiomics analysis, this study provides insight into relationship between triacylglycerol (TAG) metabolism and antibiotic biosynthesis in S. albus ZD11, an oil-preferring industrial strain. Our investigation TAG hydrolysis yielded further evidence that strain utilizes complicated strategies enabling efficient metabolism. addition, a novel secreted...
Fungal pathogens can be lethal, especially among immunocompromised populations, such as patients with AIDS and recipients of tissue transplantation or chemotherapy. Prolonged usage antifungal reagents lead to drug resistance treatment failure. Understanding mechanisms that underlie by pathogenic microorganisms is thus vital for dealing this emerging issue. In study, we show dramatic sequence changes in PDR5, an ABC (ATP-binding cassette) efflux transporter protein gene opportunistic fungal...
The general secretion (Sec) pathway plays a prominent role in bacterial protein export, and the accessory component SecDF has been shown to improve transportation efficiency. Inspection of Streptomyces coelicolor genome reveals unexpected presence two different forms secDF homologous genes: one fused form (secDF) other separated (secD secF). However, functional homologs S. not yet determined. Transcriptional analysis that these genes are constitutively expressed. transcript levels secD secF...
Abstract Background Approximately 50% of breast mucinous carcinomas (MCs) are oval and have the possibility being misdiagnosed as fibroadenomas (FAs). We aimed to identify key features that can help differentiate MC with an shape from FA on ultrasonography (US). Methods Seventy-six MCs 71 consecutive patients 50 FAs were included in our study. All lesions pathologically diagnosed. According Breast Imaging Reporting Data System (BI-RADS), first, ultrasonographic recorded a final category was...
<sec><b>Objective</b>Despite cardiotoxicity overlap, the trastuzumab/pertuzumab and anthracycline combination remains crucial due to significant benefits. Pegylated liposomal doxorubicin (PLD), a less cardiotoxic anthracycline, was evaluated for efficacy cardiac safety when combined with cyclophosphamide followed by taxanes in human epidermal growth factor receptor-2 (HER2)-positive early breast cancer (BC).</sec><sec><b>Methods</b>In this multicenter, phase II study, patients confirmed...
Multidrug resistance protein Pdr5p is a yeast ATP-binding cassette (ABC) transporter in the plasma membrane. It confers multidrug by active efflux of intracellular drugs. However, highly polymorphic from clinical strain YJM789 loses its ability to expel azole and cyclohexmide. To investigate role amino acid changes this functional change, PDR5 chimeras were constructed segmental replacement homologous BY4741 fragments. Functions evaluated fluconazole cycloheximide assays. Their expression,...