A5102801964- Legume Nitrogen Fixing Symbiosis
- SARS-CoV-2 and COVID-19 Research
- Advanced Chemical Sensor Technologies
- Biochemical Analysis and Sensing Techniques
- COVID-19 Clinical Research Studies
- Toxin Mechanisms and Immunotoxins
- Vector-borne infectious diseases
- Heavy Metal Exposure and Toxicity
- Gut microbiota and health
- SARS-CoV-2 detection and testing
- Natural product bioactivities and synthesis
- Plant nutrient uptake and metabolism
- Agronomic Practices and Intercropping Systems
- Viral gastroenteritis research and epidemiology
- Inflammasome and immune disorders
- Trace Elements in Health
- Mycotoxins in Agriculture and Food
- Inflammatory mediators and NSAID effects
- Peptidase Inhibition and Analysis
- Endoplasmic Reticulum Stress and Disease
- Hydrogen's biological and therapeutic effects
- Traditional Chinese Medicine Analysis
- Infant Nutrition and Health
- Infection Control and Ventilation
- Wheat and Barley Genetics and Pathology
National University of Singapore
2025
First Affiliated Hospital of Henan University
2024
Huazhong University of Science and Technology
2012-2024
Shanghai Sunshine Rehabilitation Center
2024
Southern Medical University
2024
Second Hospital of Anhui Medical University
2021-2024
Anhui Medical University
2021-2024
Wuhan National Laboratory for Optoelectronics
2024
Qilu Hospital of Shandong University
2024
Chengdu University of Traditional Chinese Medicine
2017-2023
Protein misfolding in the endoplasmic reticulum (ER) activates a set of intracellular signaling pathways, collectively termed Unfolded Response (UPR). UPR promotes cell survival by reducing misfolded protein levels. If homeostasis cannot be restored, death. The molecular basis for switch between prosurvival and proapoptotic function is poorly understood. ER-resident proteins, PERK IRE1, control two key pathways. concomitantly IRE1 has clouded insight into their contributions toward life or...
Most persons infected with SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19), develop virus-specific antibodies within several weeks, but antibody titers might decline over time. Understanding timeline of is important for interpreting SARS-CoV-2 serology results. Serum specimens were collected from a convenience sample frontline health care personnel at 13 hospitals and tested to during April 3-June 19, 2020, again approximately 60 days later assess this timeline. The...
The natural polyamine spermidine and spermine have been reported to ameliorate aging aging-induced dementia.However, the mechanism is still confused.An model, senescence accelerated mouse-8 (SAMP8), was used in this study.Novel object recognition open field test results showed that oral administration of spermidine, rapamycin increased discrimination index, modified number, inner squares distance times.Spermidine activity SOD, decreased level MDA brain.Spermidine phosphorylate AMPK regulate...
Nature uses four methods of carbon chain elongation for the production 2-ketoacids, fatty acids, polyketides, and isoprenoids. Using a combination quantum mechanical (QM) modeling, protein-substrate protein metabolic engineering, we have engineered enzymes involved in leucine biosynthesis use as synthetic "+1" recursive pathway to extend 2-ketoacids. This modified preferentially selects longer-chain substrates catalysis, compared non-recursive natural pathway, can recursively catalyze five...
Quercetin is one of the most abundant dietary flavonoid compounds, and its mechanism for combating age-related neurodegenerative diseases unclear.
Over the past four decades, Bacillus biofertilizers, which are microbial formulations based on species, have significantly contributed to sustainable agriculture by enhancing crop growth, improving soil health, and reducing dependency chemical fertilizers. particularly known for their ability promote plant fix nitrogen, solubilize phosphorus, produce growth-promoting substances such as phytohormones antibiotics, emerged key players in development of eco-friendly agricultural solutions. This...
ABSTRACT The unpredictable nature of bioterrorism and the absence real-time detection systems have highlighted need for an efficient postexposure therapy Bacillus anthracis infection. One approach is passive immunization through administration antibodies that mitigate biological action anthrax toxin. We isolated characterized two protective fully human monoclonal with specificity antigen (PA) lethal factor (LF). These antibodies, designated IQNPA (anti-PA) IQNLF (anti-LF), were developed as...
BACKGROUND: Bisphenol A (BPA) is an endocrine disruptor that affects fetal growth in experimental studies.Bisphenol F (BPF) and bisphenol S (BPS), which have been substituted for BPA some consumer products, also shown endocrine-disrupting effects models.However, the of BPF BPS on humans are unknown.OBJECTIVES: Our goal was to investigate trimester-specific associations urinary concentrations BPA, BPF, with size at birth.METHODS: The present study included 845 pregnant women from Wuhan, China...
Cowpea (Vigna unguiculata) and mung bean radiata) are important legume crops yet their rhizobia have not been well characterized. In the present study, 62 rhizobial strains isolated from root nodules of these plants grown in subtropical region China were analyzed via a polyphasic approach. The results showed that 90% belonged to or related Bradyrhizobium japonicum, liaoningense, yuanmingense elkanii, while remaining represented Rhizobium leguminosarum, etli Sinorhizobium fredii. Diverse nifH...
Twenty-four Mesorhizobium strains were isolated from desert soils in the Xinjiang region of China and characterized by a polyphasic approach. These grouped into three clusters IGS-RFLP, SDS-PAGE analysis whole-cell proteins BOX-PCR analysis, corresponding to genomic species V, VI VII as found previous study. The results supported sequencing analyses rrs, IGS, atpD recA genes. Genospecies was most related septentrionale, while genospecies V both closely tianshanense, but distinct each other...
Three rhizobial strains (CCBAU 01393T, CCBAU 01389 and 03239) isolated from nodules of Caragana intermedia grown in saline-alkaline soils the north China had identical 16S rRNA genes that showed 99.7 99.5 % sequence similarities with those Rhizobium huautlense SO2T galegae USDA 4128T, respectively. Phylogenies housekeeping atpD, recA glnII confirmed their distinct position, differing recognized species. SDS-PAGE whole-cell soluble proteins a series phenotypic physiological tests allowed us...
ABSTRACT A 3-dose (0, 1, and 6 months) intramuscular (3-IM) priming series of a human dose (HuAVA) dilutions up to 1:10 anthrax vaccine adsorbed (AVA) provided statistically significant levels protection (60 100%) against inhalation for 4 years in rhesus macaques. Serum anti-protective antigen (anti-PA) IgG lethal toxin neutralization activity (TNA) were detectable following single injection HuAVA or 1:5 AVA two injections diluted (1:10, 1:20, 1:40 AVA). Anti-PA TNA highly correlated...
Aromatic azoxy compounds recently attracted wide interest for their unique liquid crystalline properties. However, biosynthetic pathways of natural products have rarely been reported. Three novel aromatic compounds, azoxymycins A, B, and C, isolated identified from Streptomyces chattanoogensis L10,