A5101461431- Traditional Chinese Medicine Analysis
- Neurological Disease Mechanisms and Treatments
- Angiogenesis and VEGF in Cancer
- Pharmacological Effects of Natural Compounds
- Neuroinflammation and Neurodegeneration Mechanisms
- Gut microbiota and health
- Autophagy in Disease and Therapy
- Traditional Chinese Medicine Studies
- Atherosclerosis and Cardiovascular Diseases
- Lipid metabolism and disorders
- Brain Metastases and Treatment
- Glioma Diagnosis and Treatment
- Metabolomics and Mass Spectrometry Studies
- Cannabis and Cannabinoid Research
- Evaluation and Optimization Models
- Additive Manufacturing and 3D Printing Technologies
- Cancer-related molecular mechanisms research
- Sirtuins and Resveratrol in Medicine
- Geotechnical Engineering and Analysis
- Intracerebral and Subarachnoid Hemorrhage Research
- Phytoestrogen effects and research
- Liver Disease Diagnosis and Treatment
- Tryptophan and brain disorders
- Hydrogen's biological and therapeutic effects
- Kruppel-like factors research
Guangzhou University of Chinese Medicine
2015-2025
Hangzhou Normal University
2023-2024
Lanzhou Jiaotong University
2021
Guangzhou University
2010
Sinopec (China)
2009
Nanjing Traditional Chinese Medicine Hospital
2008
Wessex Institute of Technology
2001-2002
University of Southampton
2001-2002
The natural polyamine spermidine and spermine have been reported to ameliorate aging aging-induced dementia.However, the mechanism is still confused.An model, senescence accelerated mouse-8 (SAMP8), was used in this study.Novel object recognition open field test results showed that oral administration of spermidine, rapamycin increased discrimination index, modified number, inner squares distance times.Spermidine activity SOD, decreased level MDA brain.Spermidine phosphorylate AMPK regulate...
Intracerebral hemorrhage (ICH) is a subtype of stroke characterized by high mortality and disability rates. To date, the exact etiology ICH-induced brain injury still unclear. Moreover, there no effective treatment to delay or prevent disease progression currently. Increasing evidence suggests that ferroptosis plays dominant role in pathogenesis ICH injury. Baicalin main active ingredient Chinese herbal medicine Scutellaria baicalensis . It has been reported exhibit neuroprotective effects...
Sleep deprivation refers to an intentional or unintentional reduction in sleep time, resulting insufficient sleep. It is often caused by disorders, work demands (e.g., night shifts), and study pressure. promotes Aβ deposition tau hyperphosphorylation, which a risk factor for the pathogenesis progression of Alzheimer's disease (AD). Recent research has demonstrated potential involvement both AD through glial cell activation, lymphatic system, orexin circadian rhythm inflammation, gut...
Danggui Buxue Decoction (DBD) is a classic prescription of traditional Chinese medicine that mainly used for treating clinical anemia more than 800 years. This has been utilized nourishing "Qi" and enriching "Blood" women suffering from menopausal symptoms. Meanwhile, DBD the role improving angiogenesis promoting neuroprotective functions. Bone marrow-derived endothelial progenitor cells (EPCs) was suboptimal to treat focal cerebral ischemia (FCI). Thus, it's may be novel strategy combined...
Simultaneously regulating the phase morphology and dispersion of nanoparticles in multicomponent polymeric materials is a highly desired but challenging task. In this work, we investigate structural development PLLA/EGMA/SiO2 (polylactide/ethylene-acrylic ester-glycidyl methacrylate terpolymer/nanosilica) nanocomposites during melt compounding. By taking advantage temperature differences PLLA EGMA their different affinity with SiO2, polymer blend morphologies have been prepared by varying...
The Chinese formula Bushen-Yizhi (BSYZ) has been reported to ameliorate cognitive dysfunction. However the mechanism is still unclear. In this study, we employ an aging model, SAMP8 mice, explore whether BSYZ could protect dementia through SIRT1/endoplasmic reticulum (ER) stress pathway. Morris water maze and fearing condition test results show that oral administration of (1.46 g/kg/d, 2.92 g/kg/d 5.84 g/kg/d) donepezil (3 mg/kg/d) shorten escape latency, increase crossing times original...
Angelica sinensis (AS, Danggui in Chinese) is an important herbal component of various traditional formulae for the management asthenia and its tonic effects. Although AS has been shown to ameliorate cognitive damage nerve toxicity D-galactose (D-gal)-elicited senescent mice brain, effects on liver kidney injury have not yet explored. In this work, were subjected hypodermic injection with D-gal (200 mg/kg) orally gavaged (20, 40, or 80 once a day 8 successive weeks. Results revealed that...
The abnormal deposition of the extracellular amyloid-β peptide is typical pathological hallmark Alzheimer's disease. Strategies to reduce effectively alleviate neuronal degeneration and cognitive deficits Danggui-Shaoyao-San has been considered a useful therapeutic agent known for treatment However, mechanism disease remains unclear. We investigated Danggui-Shaoyao-San's effect on amyloidosis in an APP/PS1 mouse model. found alleviated mice. Additionally, ameliorated these reduced...
Previous studies proved that AS-IV could prevent blood-brain barrier (BBB) against an increase in permeability. However, its underlying molecular mechanism has not been enlightened yet. The aim of the study is to reveal potential protective astragaloside IV (AS-IV) on after ischemia-reperfusion.In vivo, neurological protection was measured by Long's five-point scale and 2,3,5-triphenyltetrazolium chloride staining. for BBB observed Evans blue extravasation technique. Endoplasmic reticulum...
The interplay between nanoparticles and polymer domains dominates the particle distribution structural evolution of multiphase blends. We herein report controlled silica (SiO2) in poly(l-lactic acid) (PLLA)/ethylene-acrylic ester-glycidyl methacrylate terpolymer (EGMA) blends with a typical droplet-matrix morphology. Due to thermodynamic equilibrium, SiO2 migrate from their predispersing PLLA matrix into droplet EGMA during stepwise melt compounding. However, will assemble at interface form...
SUMMARY Whether chondroitin sulfate (CS), a common ingredient naturally occurring in livestock and poultry products, improves osteoarthritis remains debating. Here, we show for the first time that CS induces steatogenesis, atherogenesis, dementia-like pathogenesis mice. Gut microbiome analysis revealed sulfatase-secreting bacteria Rikenella sulfate-reducing Desulfovibrio are enriched. Surprisingly, berberine use boosts CS-induced multi-loci inflammatory manifestations by further increasing...
Although artemisinin has been used as anti-malarial drug, accumulating evidence on the extended therapeutic potential of emerges. Apart from anti-malaria and anti-tumor, can also exert beneficial effects some metabolic disorders, such obesity, diabetes, aging-related diseases. However, whether should be applied to treatment wide-spectrum diseases is debating. Here, we discuss predisposition a raised risk malarial resistance consideration multi-target non-specific features artemisinin.
Abstract Background An interaction of the food types with gut microbiota changes is deeply implicated in human health and disease. To verify whether animal-based diets would lead to dysbiosis, systemic inflammation inflammatory pathogenesis, we fed mice chondroitin sulfate (CS), a sulfate-containing O -glycan naturally occurring livestock poultry products, monitored dynamic microbial flores, signatures, pathogenic hallmarks. Results A metagenomic analysis revealed overgrowth...
It remains obscure how to medically manage visceral obesity that predisposes metabolic disorders. Here, we show for the first time a trace amount of artemisinin (0.25 mg/kg) reduces adipose weight in an inflammatory obese mouse model induced by high-fat diet with lipopolysaccharide (HFD+LPS). HFD+LPS trigger pro-inflammatory responses, upregulate NOS2 expression, elicit potent nitric oxide (NO) burst, and reinforce mitochondrial dysfunctions facilitate adipogenesis gain. By targeting...