A5063832367- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Traditional Chinese Medicine Analysis
- Parkinson's Disease Mechanisms and Treatments
- Glutathione Transferases and Polymorphisms
- Synthesis and Biological Evaluation
- Andrographolide Research and Applications
- Air Quality and Health Impacts
- Plant-based Medicinal Research
- Neurological Disease Mechanisms and Treatments
- Genomics, phytochemicals, and oxidative stress
- Quinazolinone synthesis and applications
- Endoplasmic Reticulum Stress and Disease
- Phenothiazines and Benzothiazines Synthesis and Activities
- Adenosine and Purinergic Signaling
- Autophagy in Disease and Therapy
- Olfactory and Sensory Function Studies
- Alzheimer's disease research and treatments
Guangzhou University of Chinese Medicine
2014-2019
Guangzhou Medical University
2019
Evodiae fructus (EF) has been used in China for thousands of years as an analgesic, antiemetic, anti-inflammatory and antidiarrheal drug. EF is a toxic drug causes hepatotoxicity humans. Although recent chronic toxicity studies performed on aqueous extract revealed that it can produce obvious cumulative hepatotoxicity, the mechanism behind this still uncertain. In present study, we investigated influence oxidative stress, mitochondrial permeability transition, adenosine triphosphate (ATP),...
Parkinson's disease (PD), the second most common neurodegenerative disease, is characterized by progressive loss of dopaminergic neurons in substantia nigra. Although molecular mechanisms underlying neuronal degeneration PD remain unclear, neuroinflammation considered as vital mediator pathogenesis and progression PD. Bushen-Yizhi Formula (BSYZ), a traditional Chinese medicine, has been demonstrated to exert antineuroinflammation our previous studies. However, it remains unclear whether BSYZ...
A rapid sensitive analytical method was established and validated to investigate levistolide in rat plasma by liquid chromatography-tandem mass spectrometry operated the positive ion mode. Levistilide (LA) internal standard (IS) andrographolide (AD), mixed with sample, were separated on a reversed phase Spursil™ C18 5 µm column. The precursor/product transitions (m/z) 398.5/381.3 for LA 368.0/351.1 AD. calibration curve linear over range from 1,250 ng/mL oral administration 10-4,000...
Artemisitene (ATT) activates the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) by increasing its stabilization and reducing ubiquitination. The cysteine (Cys) residues of cytosolic Nrf2 repressor Kelch-like ECH-associated protein-1 (Keap1) function as redox sensors may be crucial in activating Nrf2. To determine whether ATT-induced activation is dependent on modification Keap1 to elucidate underlying mechanism, we transfected cell lines with six different mutant constructs, each a Cys...
Parkinson's disease (PD) is characterized by progressive degeneration of dopaminergic neurons in the substantia nigra (SN)-striatum circuit, which associated with glial activation and consequent chronic neuroinflammation. Optimized Yinxieling Formula (OYF) a Chinese medicine that exerts therapeutical effect antiinflammation property on psoriasis. Our previous study has proven pretreatment OYF could regulate glia-mediated inflammation an acute mouse model PD induced...
Parkinson’s disease (PD) is marked by the progressive degeneration of dopaminergic neurons (DAN) accompanied glial activation. Thus, inhibiting activation that occurs during this could be an effective method for treating PD. Optimized Yinxieling Formula (OYF), a Chinese medicinal formula, which used to efficiently treat autoimmune psoriasis, has been proved display potential immunomodulatory effects in inflammation-associated diseases. This study assessed therapeutic benefits OYF on...