A5101877477- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Genomics, phytochemicals, and oxidative stress
- Medicinal Plant Pharmacodynamics Research
- Natural product bioactivities and synthesis
- Pancreatic function and diabetes
- Spinal Cord Injury Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Inflammasome and immune disorders
- Flavonoids in Medical Research
- Phytoestrogen effects and research
- Ethnobotanical and Medicinal Plants Studies
- Pancreatic and Hepatic Oncology Research
- Acute Ischemic Stroke Management
- Renal Transplantation Outcomes and Treatments
- Gastrointestinal Tumor Research and Treatment
- Xenotransplantation and immune response
- Parkinson's Disease Mechanisms and Treatments
- Bone Metabolism and Diseases
- Curcumin's Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Neurogenesis and neuroplasticity mechanisms
- Traditional Chinese Medicine Analysis
- Nerve injury and regeneration
Southern Medical University
2025
Nanfang Hospital
2025
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2020-2025
Wenzhou Medical University
2020-2025
Guangzhou University of Chinese Medicine
2013-2024
Guangdong Provincial Hospital of Traditional Chinese Medicine
2014-2024
Guangdong Academy of Medical Sciences
2014-2019
Guangzhou University
2018
Purpose: Gouty arthritis could be triggered by the deposition of monosodium uric acid (MSU) crystals. Palmatine (PAL), a protoberberine alkaloid, has been proven to possess compelling health-beneficial activities. In this study, we aimed explore effect PAL on LPS plus MSU crystal-stimulated gouty in vitro and vivo. Methods: PMA-differentiated THP-1 macrophages were primed with then stimulated crystal presence or absence PAL. The expression pro-inflammatory cytokines oxidative stress-related...
Despite extensive studies on CD4+CD25+ regulatory T cells (Tregs), their application in adoptive transfer therapies is still not optimal immune-competent wild-type (WT) animal models. Therefore, it compelling to search for more potent Tregs potential clinical application. Mounting evidence has shown that naturally occurring CD8+CD122+ are also Tregs. However, suppression allograft rejection, efficiency and underlying mechanisms remain unclear. Using a murine allotransplantation model, we...
BACKGROUND Duodenal adenocarcinoma (DA), a rare gastrointestinal malignancy, lacks clear natural history and management strategies. This study aimed to investigate the long-term outcomes of patients with DA, focusing on survival impact tumor characteristics, surgery, adjuvant therapy. AIM To bridge this knowledge gap, we conducted hospital-based cohort in our 15-year experience DA at investigating along analyzing operations therapy outcomes. METHODS A retrospective analysis 208 diagnosed...
Abstract Background Neuronal structure is disrupted after spinal cord injury (SCI), causing functional impairment. The effectiveness of exercise therapy (ET) in clinical settings for nerve remodeling post-SCI and its underlying mechanisms remain unclear. This study aims to explore the effects related ET on SCI rats. Methods We randomly assigned rats various groups: sham-operated group, + ET, alone, H89, H89. Techniques including motor-evoked potential (MEP), video capture analysis,...
Parkinson's disease is recognized as the second most common neurodegenerative disorder after Alzheimer's disease, characterized by loss of dopominergic neurons in substantia nigra pars compacta and can be experimentally mimicked use neurotoxin, 1‑methyl‑4‑phenylpyridinium ion (MPP+), vitro models. In this study, we investigated potential protective effects apigenin (AP), galangin genkwanin, naturally occurring plant flavonoids, on MPP+‑induced cytotoxicity cultured rat adrenal...
Curcumin (CUR) possesses pronounced anti‐inflammatory and antioxidant activities. Generally, the clinical application of CUR is restricted due to its apparent unstability poor absorption, biological activities may be closely associated with metabolites. Tetrahydrocurcumin (THC) octahydrocurcumin (OHC) are two major hydrogenated metabolites appreciable potentials. Here, we comparatively explored CUR, THC, OHC in lipopolysaccharide‐ (LPS‐) induced RAW264.7 macrophages. The results revealed...
Calcineurin inhibitor cyclosporine is widely used as an immunosuppressant in clinic. However, mounting evidence has shown that hinders tolerance induction by dampening Tregs. Therefore, it of paramount importance to overcome this pitfall. Kaempferol was reported inhibit DC function. Here, we found kaempferol delayed islet allograft rejection. Combination and low-dose, but not high-dose, induced majority recipient mice. Although plus either dose largely abrogated proliferation...
CD8(+) T cells are regulatory (Tregs) that suppress both alloimmunity and autoimmunity in many animal models. This class of includes the CD8(+)CD28(-), CD8(+)CD103(+), CD8(+)FoxP3(+) CD8(+)CD122(+) subsets. The mechanisms action these not fully understood; however, secretion immunosuppressive cytokines, such as interleukin (IL)-4, IL-10 transforming growth factor beta (TGF-β) well direct killing target via Fas L/Fas perforin/granzyme B pathways have been demonstrated various Further studies...
Traditional Chinese medicine (TCM) has been extensively applied as preferable herbal remedy for menopausal symptoms. In the present work, potential of a TCM recipe named RRF, composed Radix Astragali, Angelicae Sinensis, and Folium Epimedii, was investigated on natural aging rat model. After administration RRF (141, 282, 564 mg/kg/d), circulated estradiol (E 2 ) level increased accompanied by reduction serum follicle stimulating hormone (FSH). But no significant impact lutenizing (LH)...
// Yeshu Wang 1, * , Qingfeng Xie 2, Chun-Ling Liang 3, Qiaohuang Zeng 1 and Zhenhua Dai 3 Graduate School, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, P.R. China 2 Center for Regenerative Translational Guangdong Provincial Academy Medical Sciences, Hospital Section Immunology, These authors have contributed equally to this work Correspondence to: Dai, email: zdai2009@outlook.com Keywords: autoimmunity, type diabetes, regulatory T cells, medicine Abbreviations: CsA,...
Parkinson's disease (PD) is characterized by progressive degeneration of dopaminergic neurons in the substantia nigra (SN)-striatum circuit, which associated with glial activation and consequent chronic neuroinflammation. Optimized Yinxieling Formula (OYF) a Chinese medicine that exerts therapeutical effect antiinflammation property on psoriasis. Our previous study has proven pretreatment OYF could regulate glia-mediated inflammation an acute mouse model PD induced...
The interactions between dietary cholesterol and intestinal microbiota strongly affect host health.
Background: Modified Dachaihu decoction (MDD) is a herbal prescription that has shown promising therapeutic benefits in ameliorating pulmonary diseases clinical practice. However, the detailed mechanisms remain unclear. Objective: This study aimed to elucidate lung-protective effects of MDD against acute lung injury (ALI) and involvement underlying mechanisms. Methods: High-performance liquid chromatography (HPLC) was performed identify main active ingredients MDD. Network pharmacological...
β-patchoulene (β-PAE) is one of the essential tricyclic sesquiterpenes patchouli oil while epoxide (β-PAO) oxidative product β-PAE which can only be found in with long storage period. Our previous researches demonstrated that both and β-PAO exert potent anti-inflammatory activity vivo, but more valuable still remains uncertain. Therefore, this study adopts model LPS-stimulated RAW264.7 macrophages to compare on activity. According our results, was superior anti-inflammation as evidence by...
Achieving long-term allograft survival or tolerance without continuously global immunosuppression is a highly desirable goal in transplantation. The objective of this study to induce conventional via short-term treatments with novel protein ESAT-6, which originally identified as T cell Ag the culture filtrate M. tuberculosis. Previous studies have shown that ESAT-6 virulence factor promotes growth and pathogenesis tuberculosis while briefly weakening an individual's immunity. In study,...
Abstract Immune responses are subdued in immune privileged sites, which provide a unique opportunity to prolong cellular allograft survival. We and others have previously shown that inducing tolerance of islet allografts transplanted murine testes is easier than conventional sites. However, it not practical transplant islets human testes. Here we found immunization B6 recipients with irradiated Balb/C splenocytes through testicular injection, 7 14 days before transplantation under the kidney...
Abstract Background The blood-spinal cord barrier (BSCB) can be seriously damaged after SCI and is considered to a therapeutic target. Exercise training recognized method for the treatment of SCI. destruction BSCB mediated by matrix metalloproteinase (MMP) leads inflammation, neurotoxin production, apoptosis neurons. failure effective regeneration new blood vessels also an important reason difficulty recovery We introduced underwater-treadmill (TT) first time, which help rats successfully...