A5003529964- Traditional Chinese Medicine Analysis
- Ginseng Biological Effects and Applications
- Cholinesterase and Neurodegenerative Diseases
- Natural product bioactivities and synthesis
- Metabolomics and Mass Spectrometry Studies
- Phytoestrogen effects and research
- Food Quality and Safety Studies
- Ziziphus Jujuba Studies and Applications
- Pharmacological Effects of Natural Compounds
- Nicotinic Acetylcholine Receptors Study
- Fungal Biology and Applications
- Cancer, Hypoxia, and Metabolism
- Plant-based Medicinal Research
- Phytochemicals and Antioxidant Activities
- Medicinal Plant Pharmacodynamics Research
- Erythropoietin and Anemia Treatment
- Medicinal Plants and Bioactive Compounds
- Phytochemistry and Biological Activities
- Identification and Quantification in Food
- Ginkgo biloba and Cashew Applications
- Medicinal Plant Extracts Effects
- Bone Metabolism and Diseases
- Neuroscience and Neuropharmacology Research
- Mitochondrial Function and Pathology
- Computational Drug Discovery Methods
Nanjing Agricultural University
2025
Hong Kong University of Science and Technology
2015-2024
University of Hong Kong
2015-2024
HKUST Shenzhen Research Institute
2016-2024
Chinese Medical Center
2018
City University of Hong Kong, Shenzhen Research Institute
2017-2018
University of Cambridge
2013
The University of Texas MD Anderson Cancer Center
2012
University of Macau
2005
First Affiliated Hospital of Anhui Medical University
2005
Radix Astragali (root of Astragalus; Huangqi) is a popular traditional Chinese medicine, and Astragalus membranaceus A. var. mongolicus are two commonly used species; however, there many species that could act as adulterants Astragali. To find the chemical composition Astragali, main constituents including flavonoids, saponins, polysaccharides, amino acids, trace elements were determined in Radices mongolicus, its eight adulterants, propinquus, lepsensis, aksuensis, hoantchy, hoantchy subsp....
Root of Panax notoginseng (Radix Notoginseng, Sanqi) is a well-known traditional Chinese medicine and mainly cultivated in Wenshan Yunnan, China. The active constituents include saponin, dencichine, flavonoid, polysaccharide; however, the levels these components vary different geographical regions growth also show seasonal variation. By using high-performance liquid chromatography spectrophotometry, contents notoginsenoside R1, ginsenoside Rg1, Rb1, Rd, polysaccharide were determined...
The roots of Angelica sinensis (Danggui), a traditional Chinese medicine, have been used for invigorating blood circulation over 2000 years in China. Three common species are found Asia: A. from China, acutiloba Japan, and gigas Korea. By using molecular genetic approach, the 5S-rRNA spacer domains three were amplified, their nucleotide sequences determined. Diversity DNA among various was domains, which could serve as markers authentic identification roots. In chemical analyses, main...
Chinese date, the fruit of Ziziphus jujuba Mill., has thousands years cultivation history, and about 700 cultivars dates in China. Two types are commonly found market: (i) fresh immature consumed as fruits, (ii) dried mature used medicines. Here, chemical biological properties these were revealed. Different sources showed similar profiles; however, amounts identified chemicals a great variation. The amount nucleotides, flavonoids polysaccharides could be affected by its maturity drying...
Radix Astragali (RA) is commonly used as a health food supplement to reinforce the body vital energy. Flavonoids, including formononetin, ononin, calycosin, and calycosin-7-O-β-d-glucoside, are considered be major active ingredients within RA. Here, we provided different lines of evidence that RA flavonoids stimulated expression erythropoietin (EPO), central regulator red blood cell mass, in cultured human embryonic kidney fibroblasts (HEK293T). A plasmid containing hypoxia response element...
The non-classical function of acetylcholine (ACh) has been reported in neuroinflammation that represents the modulating factor immune responses via activation α7 nicotinic receptor (α7 nAChR), i.e., a cholinergic anti-inflammatory pathway (CAP). Acetylcholinesterase (AChE), an enzyme for ACh hydrolysis, proposed to have cells. However, involvement AChE is unclear. Here, cultured BV2 cell, microglial cell line, and primary microglia from rats were treated with lipopolysaccharide (LPS) induce...
Cordyceps sinensis is a well-known traditional Chinese medicine, and some of the active components are nucleosides. The analysis nucleosides in material has been performed by reversed-phase high-performance liquid chromatography (HPLC) with gradient elution or spectrometry. Here, we have explored possibility using capillary electrophoresis to determine content three major (adenosine, guanosine uridine) Cordyceps. Capillary needs no gradients, it provides better separation due its higher...
Danggui Buxue Tang (DBT) is a simple decoction, having about 800 years of usage in China to treat menopausal irregularity women, which contains two herbs: Radix Astragali (Huangqi) and Angelicae Sinensis (Danggui). Traditionally, boiling water has been used for preparing DBT; however, the optimized conditions extraction have not yet determined. Here, amounts Astragali-derived astragaloside IV, calycosin, formononetin, Sinensis-derived ferulic acid ligustilide were determined DBT, extracted...
Flavonoids, a group of compounds mainly derived from vegetables and herbal medicines, share chemical resemblance to estrogen, indeed some which have been used as estrogen substitutes. In searching for possible functions flavonoids, the neuroprotective effect in brain could lead novel treatment, or prevention, neurodegenerative diseases. Here, different subclasses flavonoids were analyzed its inductive role neurite outgrowth cultured PC12 cells. Amongst tested flavonol aglycone, isorhamnetin...
Yu Ping Feng San (YPFS), a Chinese herbal decoction, is composed of Astragali Radix (AR; Huangqi), Atractylodis Macrocephalae Rhizoma (AMR; Baizhu) and Saposhnikoviae (SR; Fangfeng) in weight ratio 1∶2∶1. Clinically, YPFS has been widely used to regulate immune functions; however, the action mechanism it not known. Here, we addressed this issue by providing detail analyses chemical biological properties YPFS. By using rapid resolution liquid chromatography coupled with mass spectrometry,...
The fruit of Ziziphus jujuba Mill., known as jujube or Chinese date, is commonly consumed a health supplement herbal medicine worldwide. To study the beneficial role in regulating immune response, we investigated its roles on expressions pro‐inflammatory cytokines cultured macrophages. Application chemically standardized water extract for 24 h stimulated transcriptional expression interleukin (IL)‐1β, IL‐6, and tumor necrosis factor (TNF)‐α RAW 264.7 In contrast, pretreatment with suppressed...
Pterostilbene, a stilbenoid found in vegetables and natural products, has therapeutic potential due to its multiple pharmacological actions. In the brain, nerve growth factor (NGF) is pivotal neurotrophic factor, serving for neuronal survival differentiation. The decline NGF levels aged individuals contributes development of neurodegenerative processes cognitive impairment. Here, we aim explore effect pterostilbene on promoting neuron-like differentiation PC12 cells, well-established model...
Rhizoma Curcumae (Ezhu) is a traditional Chinese medicine that has been used in removing blood stasis and alleviating pain for over thousand years. Three species of Curcuma rhizomes are being used, which include wenyujin, phaeocaulis, kwangsiensis. In China, the production largely depends on agricultural farming. The essential oils considered as active constituents Curcumae, curdione, curcumol, germacrone. On basis yield germacrone an orthogonal array design, optimized extraction condition...
Danggui Buxue Tang (DBT), a Chinese medicinal decoction that is used commonly for treating women's ailments, contains Radix Astragali and Angelicae Sinensis. The ratio of Sinensis in DBT should be 5 : 1 as described China 1247 A.D. In order to verify the efficacy this ancient formulation stimulating immune responses, prepared from different drug ratios was applied onto cultured T-lymphocytes macrophages. T-lymphocytes, induced markedly cell proliferation, secretion interleukin-2...
Danggui Buxue Tang (DBT), a Chinese herbal decoction used to treat ailments in women, contains Radix Astragali (Huangqi; RA) and Angelicae Sinensis (Danggui; RAS). The weight ratio of RA RAS DBT must be 5:1 as stipulated early AD 1247; however, DBT's mechanism action has never been described. Here, the estrogenic effects were investigated by determining phosphorylations estrogen receptor α (ERα) extracellular signal‐regulated kinase 1/2 (Erk1/2) cultured MCF‐7 cells. application triggered...
Danggui Buxue Tang (DBT), a Chinese herbal decoction used to treat ailments in women, contains Radix Astragali (Huangqi; RA) and Angelicae Sinensis (Danggui; RAS). When DBT was applied onto cultured MG-63 cells, an increase of cell proliferation differentiation were revealed: both these effects significantly higher than RA or RAS extract. To search for the biological markers that are specifically regulated by DBT, DNA microarray reveal gene expression profiling cells as compared RA-...
A Radix Notoginseng flavonol glycoside (RNFG), quercetin 3-O-β-D-xylopyranosyl-β-D-galactopyranoside, was isolated from roots of Panax notoginseng. Among different biological properties tested, RNFG possessed a strong activity in preventing amyloid-β