A5101604738- Genomics, phytochemicals, and oxidative stress
- Skin Protection and Aging
- Cancer, Hypoxia, and Metabolism
- Erythropoietin and Anemia Treatment
- Plant chemical constituents analysis
- Ziziphus Jujuba Studies and Applications
- Natural product bioactivities and synthesis
- Antioxidant Activity and Oxidative Stress
- Ginger and Zingiberaceae research
- Traditional Chinese Medicine Analysis
- Andrographolide Research and Applications
- Ginseng Biological Effects and Applications
- Antioxidants, Aging, Portulaca oleracea
- Medicinal Plants and Bioactive Compounds
- Biological and pharmacological studies of plants
- Dermatology and Skin Diseases
- Bioactive natural compounds
- Plant Toxicity and Pharmacological Properties
- Plant biochemistry and biosynthesis
- Essential Oils and Antimicrobial Activity
- IL-33, ST2, and ILC Pathways
- Tryptophan and brain disorders
- Lipid metabolism and disorders
- Piperaceae Chemical and Biological Studies
- NF-κB Signaling Pathways
Guangzhou University of Chinese Medicine
2014-2022
Hong Kong University of Science and Technology
2010-2014
University of Hong Kong
2010-2014
Heidelberg University
1996
Chinese date, the fruit of Ziziphus jujuba Mill., has thousands years cultivation history, and about 700 cultivars dates in China. Two types are commonly found market: (i) fresh immature consumed as fruits, (ii) dried mature used medicines. Here, chemical biological properties these were revealed. Different sources showed similar profiles; however, amounts identified chemicals a great variation. The amount nucleotides, flavonoids polysaccharides could be affected by its maturity drying...
Radix Astragali (RA) is commonly used as a health food supplement to reinforce the body vital energy. Flavonoids, including formononetin, ononin, calycosin, and calycosin-7-O-β-d-glucoside, are considered be major active ingredients within RA. Here, we provided different lines of evidence that RA flavonoids stimulated expression erythropoietin (EPO), central regulator red blood cell mass, in cultured human embryonic kidney fibroblasts (HEK293T). A plasmid containing hypoxia response element...
Andrographolide sodium bisulfate (ASB), a water-soluble form made from andrographolide through sulfonating reaction, is an antioxidant and anti-inflammatory drug; however, the antiphotoaging effect of ASB has still not been revealed. Oxidative stress inflammation are known to be responsible for ultraviolet (UV) irradiation induced skin damage consequently premature aging. In this study, we aimed at examining on UV-induced photoaging mice by physiological histological analysis examination...
The fruit of Ziziphus jujuba Mill., known as Chinese date or jujube, is consumed a health supplement worldwide. To study the role jujube in brain benefits, its effects on neuronal differentiation PC12 cells were studied. Application water extract induced neurite outgrowth cells, >25% which differentiated; this effect was similar to that nerve growth factor. In parallel, expressions neurofilaments (NFs) jujube-treated cultures showed dose-dependent increase, with highest inductions by ∼150%...
The fruit of <i>Ziziphus jujuba</i> Mill., known as jujube or Chinese date, is commonly consumed health supplement herbal medicine worldwide. To study the beneficial role in enhancing hematopoietic function, we investigated its roles on expression erythropoietin cultured Hep3B human hepatocellular carcinoma cells. Application chemically standardized water extract stimulated a dose-dependent manner, with highest response by ~ 100 % increase. A plasmid containing hypoxia element, critical...
This study was designed to explore how supercritical fluid CO2 extract of Ligusticum chuanxiong Hort (CX) protects mouse liver and kidney from d-galactose-induced injury. The antioxidant capacity CX confirmed both in vitro vivo. malondialdehyde increase attenuated by CX, as well the aspartate aminotransferase, alanine blood urea nitrogen, creatinine level. In addition, activities enzymes were markedly renewed, gene expressions these upregulated groups. results histological analysis suggested...
According to the GC-MS analysis, compositional variation was observed between samples of patchouli oil, which an unknown compound identified as patchoulene epoxide (PAO) found only in long-stored whose biological activity still remains unknown. Therefore, present study aimed evaluate potential anti-inflammatory with three vivo inflammatory models: xylene-induced ear edema, acetic acid-induced vascular permeability, and carrageenan-induced paw edema. Further investigation into its underlying...
Rhodiolae Crenulatae Radix et Rhizoma (Rhodiola), the root and rhizome of Rhodiola crenulata (Hook. f. Thoms.) H. Ohba, has been used as a traditional Chinese medicine (TCM) to increase body resistance against hypoxia in mountain sickness. The mechanism this adaptogenic property deriving from Rhodiola, however, not revealed. Erythropoietin (EPO) is an erythrocyte-specific hematopoietic hormone that increases production red blood cells: crucial factor regulating balance responding hypoxia. In...
Oxidative and inflammatory damage has been suggested to play important roles in the pathogenesis of skin photoaging. Andrographolide sodium bisulfate (ASB) is a soluble derivative andrographolide known antioxidant anti‑inflammatory properties. In present study, cellular experiments were designed investigate molecular mechanisms underlying effect ASB relieving ultraviolet (UV)‑induced photo‑damage. Following pretreatment UV irradiation, apoptosis necrosis HaCaT cells investigated by Hoechst...
Osthole is the primary active component of a number herbal plants such as Cnidium monnieri fruit. In traditional Chinese herb medicine, osthole commonly used in combination with borneol to obtain improved pharmacological effects. The aim present study was investigate effect enantiomers on pharmacokinetics osthole. An appropriate high‑performance liquid chromatography (HPLC) method applied determine concentrations plasma. Following oral administration alone or combined rats, blood samples...
This study attempted to explore the effects of white pepper and its major component piperine on puerarin administered rats. Pharmacokinetic parameters in rats were determined by oral administration (400 mg/kg) or intravenous injection (40 puerarin, pretreated with without given orally. Compared control group only, combined use (10 20 increased C max 1.30‐fold 1.64‐fold AUC 0– ∞ 133% 157%, respectively. In contrast, coadministration (125 250 decreased absorption 83% 74%, On other hand,...
Fo Shou San (FSS) is an ancient herbal decoction composed of Angelicae Sinensis Radix (ASR; Danggui) and Chuanxiong Rhizoma (CR; Chuanxiong) in a ratio 3:2. FSS mainly prescribed for patients having deficiency blood supply, it indeed has been shown to stimulate the production erythropoietin (EPO) cultured cells. In order reveal mechanism this FSS-induced EPO gene expression, upstream regulatory cascade, via hypoxia-induced signaling, was revealed here hepatocellular carcinoma cell line...
Annals of the New York Academy SciencesVolume 804, Issue 1 p. 341-361 Zonal Heterogeneity Peroxisome Proliferation in Rat Livera H. D. FAHIMI, Corresponding Author FAHIMI Department Anatomy and Cell Biology University Heidelberg Heidelberg, Germanyb Prof. H.D. Fahimi, Biology, Im Neuenheimer Feld 307, D-69120 Germany.Search for more papers by this authorK. BEIER, K. BEIER GermanySearch authorM. LINDAUER, M. LINDAUER authorA. SCHAD, A. SCHAD authorJ. ZHAN, J. ZHAN PILL, PILL Medical Research...
Although the mortality of skin cancer patients is relatively low, there are still a large number died these tumors at high incidence rate. Chronic exposure to solar UV irradiation most common cause nonmelanoma tumors. Our research aimed explore effects andrographolide sodium bisulfate (ASB) on UV-induced and reveal underlying molecular mechanism. In present study, histopathology changes, immunohistochemical analysis, ELISA analysis western blot were mainly used in vivo. The results indicated...
Abstract Gleditsiae Fructus Abnormalis and Sinensis are obtained from different developmental stages of fruits Gleditsia sinensis Lam. (Leguminosae). The possible interchangeable usage the two fruits, however, has long been very controversial. Here, high performance liquid chromatography coupled with diode array detection was developed to explore their chemical fingerprinting profiles. Besides, amounts aglycones saponin compounds, echinocystic acid oleanolic in both were quantified. results...