A5024140704- Nerve injury and regeneration
- Alzheimer's disease research and treatments
- Spinal Cord Injury Research
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Nerve Injury and Rehabilitation
- Cerebrospinal fluid and hydrocephalus
- Alkaloids: synthesis and pharmacology
- Neuroscience of respiration and sleep
- Neurological Disease Mechanisms and Treatments
- Tissue Engineering and Regenerative Medicine
- Dementia and Cognitive Impairment Research
- Nitric Oxide and Endothelin Effects
- Intracerebral and Subarachnoid Hemorrhage Research
- Pain Mechanisms and Treatments
- Signaling Pathways in Disease
- Neuroendocrine regulation and behavior
- Magnolia and Illicium research
- Tryptophan and brain disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Ion channel regulation and function
- Supramolecular Self-Assembly in Materials
- Neonatal Respiratory Health Research
- Anesthesia and Neurotoxicity Research
- Berberine and alkaloids research
University of Hong Kong
2006-2024
South China University of Technology
2024
Guangzhou Medical University
2024
Guangzhou First People's Hospital
2024
Chinese University of Hong Kong
2013-2024
University of Macau
2024
Third Affiliated Hospital of Sun Yat-sen University
2024
Chinese Academy of Sciences
2022-2024
Jinan University
2024
Sun Yat-sen University
2024
A bioinspired hydrogel composed of hyaluronic acid-
Honokiol (HO) exerts neuroprotective effects in several animal models of Alzheimer's disease (AD), but the poor dissolution hampers its bioavailability and therapeutic efficacy.A novel honokiol nanoscale drug delivery system (Nano-HO) with smaller size excellent stability was developed this study to improve solubility HO. The anti-AD Nano-HO determined.Male TgCRND8 mice were daily orally administered or HO at same dosage (20 mg/kg) for 17 consecutive weeks, followed by assessment spatial...
Abstract The fluid‐filled cystic cavity sealed by a dense scar developed following traumatic spinal cord injury (SCI) has been major obstacle to neural regeneration and functional recovery. Here the transected lesion is bridged using self‐assembling peptide (F‐SAP) hydrogel loaded with membrane‐permeable intracellular sigma (ISP) LAR (ILP), targeted at perturbing chondroitin sulfate proteoglycan (CSPG) inhibitory signaling. As compared F‐SAP chondroitinase ABC, F‐SAP+ISP/ILP promotes...
Our group has shown that the polysaccharides extracted from Lycium barbarum (LBP) are neuroprotective for retinal ganglion cells (RGCs) in different animal models. Protecting RGCs secondary degeneration is a promising direction therapy glaucoma management. The complete optic nerve transection (CONT) model can be used to study primary of RGCs, while partial (PONT) because and separated location same retina this model; other situations, these types difficult distinguish. In order examine which...
Alzheimer’s disease (AD) is a common neurodegenerative characterized by progressive memory loss. Magnolol (MN), the main active ingredient of Magnolia officinalis , possesses anti-AD effects in several experimental models AD. In this study, we aimed to explore whether MN could ameliorate cognitive deficits TgCRND8 transgenic mice and elucidate its molecular mechanisms. Male were orally administered with (20 40 mg/kg) daily for 4 consecutive months, followed assessing spatial learning...
Abstract The molecular link between amyloid-β plaques and neurofibrillary tangles, the two pathological hallmarks of Alzheimer’s disease, is still unclear. Increasing evidence suggests that peptide activates multiple regulators cell cycle pathways, including transcription factors CDKs E2F1, leading to hyperphosphorylation tau protein. However, exact pathways downstream amyloid-β-induced imbalance are unknown. Here, we show PAX6, a factor essential for eye brain development which quiescent in...
Using two different lesion models, the spinal root avulsion and distal nerve axotomy, present study investigated effects of known neurotrophic factors on motoneuron survival in newborn rats. Results show that 100% motoneurons lesioned segment die at 1 week following avulsion, more than 80% them 2 weeks axotomy. Local application GDNF can rescue 92% up to from degeneration due almost BDNF fails prevent any death rats but it about 50% CNTF IGF-1 fail either axotomy or avulsion. Thus, comparing...
This study was undertaken to elucidate the molecular mechanisms by which lithium regulates development of spinal cord-derived neural progenitor cells (NPCs) in vitro and after transplanted vivo. Our results show that at therapeutic concentration significantly increases proliferation neuronal differentiation NPCs vitro. Specific ELISAs, western blotting, quantitative real-time RT-PCR assays demonstrate treatment elevates expression production brain-derived neurotrophic factor (BDNF) culture....
Gut dysbiosis, a well-known risk factor to triggers the progression of Alzheimer's disease (AD), is strongly associated with metabolic disturbance. Trimethylamine
Increasing evidence suggests that activation of satellite glia cells (SGCs) in sensory ganglia play important roles the development neuropathic pain. The present study aimed to investigate involvement SGC a novel model motor nerve injury induced pain hypersensitivity. was established by cervical 8 ventral root avulsion (C8VA). Glial fibrillary acidic protein (GFAP) used as marker activation. Unilateral C8VA resulted mechanical allodynia, but not thermal hyperalgesia bilateral paws....
In the present study, we transplanted E13.5 spinal cord–derived neural progenitor cells (NPCs) into acutely avulsed ventral horn of adult rats. The results showed that NPCs survived and integrated nicely within host at 6 weeks post-grafting. Although majority grafted differentiated astrocytes only a small proportion neuronal cells, interestingly, in significantly enhanced survival injured motoneurons promoted their regeneration peripheral nerve (PN) graft, as revealed by retrograde...
We previously showed that motor nerves are superior to sensory in promoting axon regeneration after spinal root avulsion. It is, however, impractical use as grafts. One potential approach enhancing axonal using is deliver trophic factors the graft. Here, we examined regulation of receptors for brain-derived neurotrophic factor, glial cell line-derived ciliary and pleiotrophin avulsion adult rats. then tested their survival-promoting neuroregenerative effects on motoneurons. The results...
Peripheral nerve (PN) transplantation and ventral root implantation are the two common types of recovery operations to restore connection between motoneurons their target muscles after brachial plexus injury. Despite experience accumulated over past decade, fundamental knowledge is still lacking concerning efficacy microsurgical interventions. Thirty-eight adult female Sprague–Dawley rats were divided into 5 groups. Immediately following avulsion, animals in first group (n = 8) second...