A5089711006- Nerve injury and regeneration
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- 3D Printing in Biomedical Research
- Supramolecular Self-Assembly in Materials
- Graphene and Nanomaterials Applications
- Neuroscience and Neural Engineering
- Spinal Cord Injury Research
- Polymer Surface Interaction Studies
- RNA Interference and Gene Delivery
- Hydrogels: synthesis, properties, applications
- Advanced Sensor and Energy Harvesting Materials
- Silk-based biomaterials and applications
- Mesenchymal stem cell research
- Biomedical Ethics and Regulation
- Neurogenesis and neuroplasticity mechanisms
- Conducting polymers and applications
- biodegradable polymer synthesis and properties
- Nerve Injury and Rehabilitation
- Signaling Pathways in Disease
- Polydiacetylene-based materials and applications
- Wound Healing and Treatments
- Advanced biosensing and bioanalysis techniques
- Planarian Biology and Electrostimulation
- Electrochemical sensors and biosensors
Jinan University
2015-2025
Third Affiliated Hospital of Sun Yat-sen University
2020-2025
Sun Yat-sen University
2009-2025
Chinese University of Hong Kong
2014-2016
University of Hong Kong
2015-2016
Wuzhou University
2016
National University of Singapore
2009-2012
Institute of Bioengineering and Nanotechnology
2009-2010
Zhengzhou University
2005
Self-assembling peptide (SAP) RADA16-I (Ac-(RADA)4-CONH2) has been suffering from a main drawback associated with low pH, which damages cells and host tissues upon direct exposure. In this study, we presented strategy to prepare nanofiber hydrogels two designer SAPs at neutral pH. was appended functional motifs containing cell adhesion RGD neurite outgrowth IKVAV. The were specially designed have opposite net charges the combination of created hydrogel (-IKVAV/-RGD) characterized by...
Hydrogel-based regenerated scaffolds show promise as a platform for neural regeneration following spinal cord injury (SCI). Nevertheless, the persistent problem of poor mechanical strength and limited integration with host tissue still exists. In this study, bioinspired hydrogel highly sophisticated features after SCI is developed. The composed dihydroxyphenylalanine (DOPA)-grafted chitosan designer peptide, offering unique set qualities such being injectable, having self-healing abilities,...
Local reconstruction of a permissive environment with biomaterials is promising strategy to treat spinal cord injury (SCI). We reported hybrid hydrogel fabricated from small functional self-assembling peptide (F-SAP) and large silk fibroin (SF). The diffusion SF micelles into F-SAP solution was driven by the dynamic synergy between osmotic pressure F-SAP/SF electrostatic interactions, resulting in rearrangement formation rod-like filaments axes nearly perpendicular nanofibers. Spectroscopy...
A bioinspired hydrogel composed of hyaluronic acid-
Acute full-thickness skin wounds (FTSW) caused by extensive burns or high-energy trauma are not adequately addressed current clinical treatments. This study hypothesized that biomimetic nanofiber scaffolds (NFSs) functionalized with rich attachment of bone-marrow-derived mesenchymal stem cells (BM-MSCs) can promote wound healing in acute FTSW. Results a rat model showed both NFS and BM-MSCs contributed to the healing. Wounds group higher density achieved complete closure 8 days earlier than...
The harsh local micro-environment following spinal cord injury (SCI) remains a great challenge for neural regeneration. Local reconstitution of favorable by biocompatible scaffolds with desirable functions has thus been an area concern. Herein, hybrid hydrogel was developed using Fmoc-grafted chitosan (FC) and Fmoc peptide (FI). Dynamic reversible π-π stacking interactions the fluorenyl rings enabled FC/FI to exhibit excellent injectable self-healing properties, as characterized visual...
Abstract The fluid‐filled cystic cavity sealed by a dense scar developed following traumatic spinal cord injury (SCI) has been major obstacle to neural regeneration and functional recovery. Here the transected lesion is bridged using self‐assembling peptide (F‐SAP) hydrogel loaded with membrane‐permeable intracellular sigma (ISP) LAR (ILP), targeted at perturbing chondroitin sulfate proteoglycan (CSPG) inhibitory signaling. As compared F‐SAP chondroitinase ABC, F‐SAP+ISP/ILP promotes...
Peripheral nerves are fragile and easily damaged, usually resulting in nervous tissue loss, motor sensory function loss. Advances neuroscience engineering have been significantly contributing to bridge the damage nerve create permissive environment for axonal regrowth across lesions. We successfully designed two self-assembling peptides by modifying RADA 16-I with functional motifs IKVAV RGD. Nanofiber hydrogel formed when combing neutral solutions together, defined as 16-Mix that overcomes...
Nerve regeneration is a serious clinical challenge following peripheral nerve injury. Lycium barbarum polysaccharide (LBP) the major component of wolfberry extract, which has been shown to be neuroprotective and promising in recovery many studies. Electrospun nanofibers, especially core-shell structured nanofibers being capable serving as both drug delivery system tissue engineering scaffolds, are well known suitable scaffolds for applications. In this study, LBP was incorporated into...
The formation of a fluid-filled cystic cavity after spinal cord injury (SCI) is major obstacle for neural regeneration. In this study, the post-SCI was bridged by functional self-assembling peptide (F-SAP) nanofiber hydrogel coupled with growth factor "cocktail". A sustained release factors achieved carefully tailoring physical hindrances and charge-induced interactions between nanofibers. Such an engineering microenvironment elicited axon regeneration, as determined tracing descending...
Poly(3,4-ethylene dioxythiophene) (PEDOT) is a promising conductive material widely used for interfacing with tissues in biomedical fields because of its unique properties. However, obtaining high charge injection capability and stability remains challenging. In this study, pristine carbon nanotubes (CNTs) modified by dopamine (DA) self-polymerization on the surface polydopamine (PDA@CNTs) were utilized as dopants PEDOT to prepare hybrid films through electrochemical deposition indium tin...
Electrical stimulation (ES) can be used to manipulate recovery after peripheral nerve injuries. Although biomaterial-based strategies have already been implemented gain momentum for ES and engineer permissive microenvironments neural regeneration, the development of biomaterials specific stimuli-responsive modulation cell properties remains a challenge. Herein, we homogeneously incorporate pristine carbon nanotubes into functional self-assembling peptide prepare hybrid hydrogel with good...
By the method of injection molding combined with thermally induced phase separation (TIPS), a novel nerve conduit plurality channels and macro-/microporous architecture was fabricated using poly (lactide-co-glycolide) (PLGA, 75:25; Mn = 1.22 × 105). The diameter conduits number could be regulated by changing parameters mold, porosity as high 95.4%. Meanwhile, hierarchical pore walls controlled through varying solution concentration contents porogen. degradation study in vitro showed that...
Chitosan (CHI) is a versatile biological material that well known for its hemostatic properties. This preliminary study evaluated several self-assembling hydrophobically modified chitosan (HM–CHI) sponges to determine their efficacy on hemostasis. Fourier transform infrared (FT-IR) spectroscopy was used the successful graft of dodecyl groups onto nitrogen atoms CHI molecules. A platelet aggregation assay revealed HM–CHI accelerated rate. Fluorescence showed changed structure fibrinogen in...
The treatment of spinal cord injury aims to reconstruct the fiber connection and restore interrupted neural pathways. Adipose mesenchymal stem cells (ADSCs) can promote recovery motor functions in injury. However, poor survival ADSCs leakage outside site after local transplantation reduce number cells, which seriously attenuates cumulative effect. We performed heterotopic on rats with severe using human loaded within self-assembly hydrogel RADA16-RGD (R: arginine; A: alanine; D: aspartic...