A5100665490- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Mesenchymal stem cell research
- RNA modifications and cancer
- AI in cancer detection
- RNA and protein synthesis mechanisms
- Fossil Insects in Amber
- Circular RNAs in diseases
- Liver physiology and pathology
- Radiomics and Machine Learning in Medical Imaging
- Cancer survivorship and care
- Diet and metabolism studies
- Head and Neck Cancer Studies
- Plant Diversity and Evolution
- Cancer Research and Treatments
- Genomics and Chromatin Dynamics
- Liver Disease Diagnosis and Treatment
- Extracellular vesicles in disease
- Voice and Speech Disorders
- Genetic factors in colorectal cancer
- Connective Tissue Growth Factor Research
- Tissue Engineering and Regenerative Medicine
- Pancreatic and Hepatic Oncology Research
- Digital Imaging for Blood Diseases
- TGF-β signaling in diseases
Fujian Medical University
2022-2024
Beijing Proteome Research Center
2023-2024
First Affiliated Hospital of Fujian Medical University
2022-2024
Harbin Institute of Technology
2024
Shandong Provincial Hospital
2023-2024
Shandong First Medical University
2024
Wenzhou Medical University
2023-2024
Shanghai Tenth People's Hospital
2022-2024
Tongji University
2022-2024
Shanghai Artificial Intelligence Laboratory
2024
Impaired wound healing in diabetics usually leads to life-threatening complications. To develop a system for fastening skin efficiently and safely diabetics, thermos-sensitive hydrogel containing the nanodrug, loaded form of gelatin microspheres (GMs), was designed deliver curcumin (Cur) as therapeutic drug. Cur is naturally existing polyphenolic compound with broad range biological functions useful potential therapies. Because molecule has weakness both bioavailability vivo stability,...
Purpose: Gouty arthritis could be triggered by the deposition of monosodium uric acid (MSU) crystals. Palmatine (PAL), a protoberberine alkaloid, has been proven to possess compelling health-beneficial activities. In this study, we aimed explore effect PAL on LPS plus MSU crystal-stimulated gouty in vitro and vivo. Methods: PMA-differentiated THP-1 macrophages were primed with then stimulated crystal presence or absence PAL. The expression pro-inflammatory cytokines oxidative stress-related...
Non-alcoholic fatty liver disease (NAFLD) is characterized by excess accumulation of triglycerides within the liver. However, whether circulating levels and cholesterol transported in triglyceride-rich lipoproteins (remnant cholesterol, remnant-C) are related to occurrence NAFLD has not yet been studied. This study aims assess association remnant-C with a Chinese cohort middle aged elderly individuals.All subjects current from 13,876 individuals who recruited Shandong REACTION study. We...
The use of speech based data in the classification Parkinson disease (PD) has been shown to provide an effect, non-invasive mode recent years. Thus, there increased interest pattern analysis methods applicable Parkinsonism for building predictive tele-diagnosis and tele-monitoring models. One obstacles optimizing classifications is reduce noise within collected samples, thus ensuring better accuracy stability. While currently used are ability invoke instance selection seldomly examined.In...
Postoperative cognitive dysfunction is a typical complication, which can be referred to as POCD. This complication common in elderly patients. Among them, POCD mainly manifested the function of patients with attention deficit and memory reduction after surgery, among serious are prone personality change, affects their social behavior ability. In context current era, cause not clear, combined results most studies, it found that central nervous inflammation, key factor affecting From...
The aim of this study was to explore the relationship between non-alcoholic fatty liver disease (NAFLD) and two blood inflammatory markers (systemic immune-inflammation (SII) index, system inflammation response index (SIRI)). National Health Nutrition Examination Survey data year 2017-2018 used for cross-sectional study. In order analyze association SII SIRI risk NAFLD, we multivariable logistic regression models, restricted cubic spline (RCS) plot, subgroup analysis data. total, there were...
Although multiple forms of dimers have been described for GPCR, their dynamics and function are still controversially discussed field. Fluorescence microscopy allows GPCR to be imaged within native context; however, a key challenge is site-specifically incorporate reporter moieties that can produce high-quality signals upon formation dimers. To this end, we propose supramolecular sensor approach detect agonist-induced dimer μ-opioid receptors (μORs) at the surface intact cells. With...
Abstract Diffuse large B cell lymphoma (DLBCL) is an aggressive blood cancer known for its rapid progression and high incidence. The growing use of immunohistochemistry (IHC) has significantly contributed to the detailed characterization, thereby playing a crucial role in guiding treatment strategies DLBCL. In this study, we developed AI-based image analysis approach assessing PD-L1 expression DLBCL patients. represents as major biomarker screening patients who can benefit from targeted...
Granulomatous experimental autoimmune thyroiditis (G-EAT) is induced by mouse thyroglobulin (MTG)-sensitized splenocytes activated in vitro with MTG and IL-12. Thyroid lesions reach maximal severity 20 days after cell transfer, usually resolve or progress to fibrosis day 60 depending on the extent of thyroid damage at 20. Our previous studies indicated that neutralization TNF-alpha FasL had no effect G-EAT induction, but promoted, while inhibited, resolution. TNF-related apoptosis-inducing...
Abstract Solenopsis invicta Buren, also known as the red imported fire ant (RIFA), has had a very negative effect on biological diversity, public safety, agriculture, and economics. Because of growth in global trade, RIFA threat to China will continue increase. To better understand characteristics newly observed distributions RIFA, we studied effects three factors including provincial areas, landcover types, climatic conditions 130 new occurrence records 2021. (1) We found that preferred...
Acetaminophen (APAP)-induced liver injury is one of the most frequent causes acute failure worldwide. Significant increases in levels miRNA-21 both tissues and plasma have been observed APAP-overdosed animals humans. However, mechanistic effect on remains unknown. In this study, we generated a new hepatocyte-specific knockout (miR-21-HKO) mouse line. miR-21-HKO background-matched sibling wild-type (WT) mice were treated with toxic dose APAP. Compared WT mice, miR-21 HKO showed an increased...
The liver is the largest solid organ in body and primarily composed of hepatocytes (HCs), endothelial cells (ECs), Kupffer (KCs), hepatic stellate (HSCs), which spatially interact cooperate with each other to maintain homeostasis. However, complexity molecular mechanisms underlying crosstalk between these different cell types remain be revealed. Here, we generated mice conditional deletion Gdf2 (also known as Bmp9 ) Bmp10 demonstrated that HSCs were major source GDF2 BMP10 liver. Using...
Abstract Background Patients with nasopharyngeal carcinoma (NPC) undergoing radiotherapy experience significant fatigue, which is frequently underestimated due to the lack of objective indicators for its evaluation. This study aimed explore longitudinal association between fatigue and nutrition status 1 week in advance. Methods From January 2021 June 2022, a total 105 NPC patients who received intensity‐modulated radiation therapy were enrolled observational study. The outcomes, including...
Abstract Extreme cold exposure has been widely considered as a cardiac stress and may result in function decompensation. This study was to examine the risk factors that contribute changes cardiovascular indicators of following extreme provide valuable insights into preservation adaptation occur real‐world environment. Seventy subjects were exposed outside (Mohe, mean temperature −17 −34°C) for one day, monitored by 24‐h ambulatory blood pressure device underwent echocardiography examination...
Diagnosis of Alzheimer's disease (AD) is very important, and MRI an effective imaging mode disease. There are many existing studies on the diagnosis based data. However, there no transfer learning between different datasets (including subjects), thereby improving sample size target dataset indirectly. Therefore, a new framework method proposed in this paper to solve problem. First, gravity used source domain data closer set. Secondly, best deviation transferred samples searched by instance...
Abstract Background: Pathological complete response (pCR) is accepted by FDA as a surrogate endpoint for accelerated approval of targeted agents in combination with chemotherapy based on better long-term outcomes compared to residual disease (Cortazar 2014). Methods: The multi-center, adaptively-randomized I-SPY2 platform trial uses pCR the primary identify investigational that will improve women stage 2/3 breast cancer high risk early recurrence, across all signatures, hormone receptor...