A5038636004- Lymphatic System and Diseases
- Alzheimer's disease research and treatments
- Angiogenesis and VEGF in Cancer
- Neuroscience and Neuropharmacology Research
- Lymphatic Disorders and Treatments
- Spine and Intervertebral Disc Pathology
- Immune cells in cancer
- Memory and Neural Mechanisms
- Neuroendocrine regulation and behavior
- Mitochondrial Function and Pathology
- Cervical and Thoracic Myelopathy
- Polysaccharides and Plant Cell Walls
- Liver Disease Diagnosis and Treatment
- Glycosylation and Glycoproteins Research
- Nerve injury and regeneration
- Retinoids in leukemia and cellular processes
- Biomarkers in Disease Mechanisms
- Clusterin in disease pathology
- Traditional Chinese Medicine Analysis
- Inflammasome and immune disorders
- Cholinesterase and Neurodegenerative Diseases
- Diabetes Treatment and Management
- Liver physiology and pathology
- Image Retrieval and Classification Techniques
- NF-κB Signaling Pathways
Shaanxi University of Chinese Medicine
2016-2025
Tibet Autonomous Region People's Hospital
2020
Shanghai Drug Administration
2019
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2017-2018
Shanghai University of Traditional Chinese Medicine
2017-2018
Shanghai Institute of Organic Chemistry
2015-2018
Chinese Academy of Sciences
2015-2018
Zhejiang Center for Disease Control and Prevention
2014-2017
Shanxi Medical University
2010-2016
University of Oklahoma Health Sciences Center
2008-2014
Abstract Developing novel drugs that can abrogate the growth and metastasis of malignant tumors is a major challenge for cancer researchers. Here we describe synthetic retinoid, namely WYC-209, which inhibits proliferation murine melanoma tumor-repopulating cells (TRCs), known to resist conventional drug treatment, with an IC 50 0.19 μM in dose-dependent manner. WYC-209 also TRCs human melanoma, lung cancer, ovarian breast culture. Interestingly, treated fail resume even after washout....
Podoplanin (PDPN), a transmembrane O-glycoprotein, is up-regulated in many tumors and involved tumor metastasis malignant progression. In previous studies, we generated functional blocking monoclonal antibody (mAb, SZ168) against the extracellular domain of human PDPN. This study aimed to investigate whether PDPN by SZ168 inhibits growth metastasis. Malignant melanoma xenograft model inoculating subcutaneously cell line C8161 into back BALB/c nude mice was used. Endogenous expression cells...
Flexible heteroarotinoids (Flex-Hets) compounds regulate growth, differentiation and apoptosis in cancer cells. The hypothesis of this study was that the lead Flex-Het, SHetA2, inhibits angiogenesis by blocking cytokine release from SHetA2 altered secretion thrombospondin-4 (TSP-4), vascular endothelial growth factor A (VEGF) fibroblast (bFGF) proteins normal cancerous ovarian renal cultures. Thymidine phosphorylase (TP) expression inhibited cancer, but not Endothelial tube formation...
Podoplanin (PDPN) is expressed on many tumors and involved in tumor metastasis. The objective of the present study was to develop an ELISA for determining soluble PDPN (sPDPN) levels as a potential novel marker plasma patients with cancers detection occurrence Mouse monoclonal antibodies (mAb) against human were developed characterized. Two anti-PDPN mAb, SZ-163 SZ-168, used sandwich detect sPDPN normal individuals. detected adenocarcinoma (87 cases, 31.09 ± 5.48 ng/ml), squamous cell...
Study Design. Cross-cultural adaptation and cross-sectional psychometric testing in a convenience sample of patients with low back pain. Objective. The aim this study was to translate adapt the Japanese Orthopaedic Association Back Pain Evaluation Questionnaire (JOABPEQ) into simplified Chinese version, assess its reliability validity. Summary Background Data. No version JOABPEQ previously available. Methods. We translated culturally adapted original English develop based on cross-cultural...
ABSTRACT Amyloid β protein (Aβ) plays a critical role in pathogenesis of Alzheimer's disease (AD). Our previous studies indicated that the sequence 31–35 Aβ molecule is an effective active center responsible for neurotoxicity vivo and vitro . In present study, we prepared novel antibody specifically targeting amyloid protein, investigated neuroprotection anti‐Aβ against 1–42 ‐induced impairments neuronal viability, spatial memory, hippocampal synaptic plasticity rats. The results showed...
Purpose This study aimed to validate the simplified Chinese version of Japanese Orthopaedic Association Cervical Myelopathy Evaluation Questionnaire (JOACMEQ) for patients with cervical spondylotic myelopathy (CSM).Methods The construct validity was conducted using confirmatory factor analysis (CFA). convergent based on loading, composite reliability (CR), and Pearson correlation coefficients (r). Internal consistency evaluated Cronbach’s α, test–retest intraclass (ICC), ceiling floor...
Intestinal microecology refers to the interaction between host and microorganisms in human intestinal tract, which is composed mainly of flora. microflora affects physiological pathological changes through metabolic activity interaction. Precancerous lesion liver a potential benign disease, may lead malignant transformation liver. It intermediate stage from transformation. Recent studies have shown that closely related occurrence precancerous lesions This study expounds bridge intestine...
To verify the anti-tumor effect of salidrosideon gastric cancer, BALB/C mice grafted with a mouse adenocarcinoma cell line MFC was used as experimental model. The were divided into four groups, one control and other three different drug administration groups. Animals in groups received Shenfoweikang herb over 60-day period starting at first day after grafting. saline controls. All sacrificed 61 days being grafted. assessed by ways: (1) tumor size periodically measured during life animals...
To explore the effects of Shanxian Granules (SXG) on diethylnitrosamine (DEN) -induced precancerous lesions in rats and its possible molecular mechanism. A total 50 male SD (190±10 g) were randomly divided into five groups. control group, DEN SXG low dose medium group high group. The received saline injection. liver cirrhosis 50mg/kg via intraperitoneal injection twice a week for 16 weeks. indexes function (ALT, AST GGT) measured by blood sampling. HE staining was used to observe...