A5102027843- Immune cells in cancer
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Metabolism and Genetic Disorders
- CRISPR and Genetic Engineering
- Neural dynamics and brain function
- Liver physiology and pathology
- Plant tissue culture and regeneration
- Neuroinflammation and Neurodegeneration Mechanisms
- Neural and Behavioral Psychology Studies
- Photosynthetic Processes and Mechanisms
- Mitochondrial Function and Pathology
- Mental Health Research Topics
- Phagocytosis and Immune Regulation
Shaanxi University of Chinese Medicine
2023-2025
Beihang University
2024-2025
South China Agricultural University
2022
Background/Objectives: Schizophrenia is a severe psychiatric disorder characterized by deficits in perception and advanced cognitive functions. Prior studies have reported abnormal lateralization cortical morphology functional connectivity schizophrenia. However, it remains unclear whether schizophrenia affects hemispheric asymmetry the hierarchical organization of connectome. Methods: Here, we apply gradient mapping framework to connectome estimate first three gradients, which characterize...
Age-related hearing loss (ARHL) is a common sensory disability among older adults and considered risk factor for the development of dementia. Previous work has shown altered brain connectome topology in ARHL, including abnormal nodal strength clustering coefficient. However, whether ARHL affects hierarchical organization structural how these alterations relate to transcriptomic signatures remain unknown. Here, we apply gradient mapping framework derived from diffusion magnetic resonance...
Introduction Major depressive disorder (MDD) is a debilitating disease involving sensory and higher-order cognitive dysfunction. Previous work has shown altered asymmetry in MDD, including abnormal lateralized activation disrupted hemispheric connectivity. However, it remains unclear whether how MDD affects functional asymmetries the context of intrinsic hierarchical organization. Methods Here, we evaluate intra- inter-hemispheric first three gradients, characterizing unimodal-transmodal,...
Summary Functional genomics, synthetic biology and metabolic engineering require efficient tools to deliver long DNA fragments or multiple gene constructs. Although numerous assembly methods exist, most are complicated, time‐consuming expensive. Here, we developed a simple flexible strategy, unique nucleotide sequence‐guided nicking endonuclease (UNiE)‐mediated (UNiEDA), for cloning of DNAs multigene stacking. In this system, set 15‐nt 3′ single‐strand overhangs were designed produced by...
The brain's structural connectome supports signal propagation between neuronal elements, shaping diverse coactivation patterns that can be captured as functional connectivity. While the link structure and function remains an ongoing challenge, prevailing hypothesis is structure-function relationship may itself gradually decoupled along a macroscale gradient spanning unimodal to transmodal regions. However, this strongly constrained by underlying models which neglect requisite signaling...