A5054725986- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Alzheimer's disease research and treatments
- Neurogenesis and neuroplasticity mechanisms
- Neuropeptides and Animal Physiology
- Neuroscience and Neural Engineering
- Receptor Mechanisms and Signaling
- Porphyrin and Phthalocyanine Chemistry
- Neuroinflammation and Neurodegeneration Mechanisms
- Nuclear Receptors and Signaling
- Cholinesterase and Neurodegenerative Diseases
- Axon Guidance and Neuronal Signaling
- Adenosine and Purinergic Signaling
- Neural dynamics and brain function
- Nicotinic Acetylcholine Receptors Study
- Cancer and Skin Lesions
- GDF15 and Related Biomarkers
- Porphyrin Metabolism and Disorders
- Neurological Disease Mechanisms and Treatments
- Circadian rhythm and melatonin
- Diabetes Treatment and Management
- Phosphodiesterase function and regulation
- Photoreceptor and optogenetics research
- Stress Responses and Cortisol
University of California, San Diego
2020-2024
Shanxi Medical University
2012-2021
Changzhi Medical College
2019-2021
Nanyang Technological University
2016-2021
University of Warwick
2016
Alzheimer's disease (AD), the most prevalent neurodegenerative in elderly, leads to progressive loss of memory and cognitive deficits. Amyloid-β protein (Aβ) brain is thought be main cause AD. Melatonin, an indole hormone secreted by pineal gland, has been reported produce neuroprotective effects. We examined whether melatonin could protect Aβ-induced impairments hippocampal synaptic plasticity, neuronal cooperative activity, learning memory. Rats received bilateral intrahippocampal...
Although appropriate exercise is beneficial for enhancing brain functions, high-intensity (HIE)-induced cognitive dysfunction causing more and concerns nowadays. In the present study, we observed effects of treadmill running on spatial learning adult Sprague Dawley male rats in Y-maze (n = 16 per group), investigated its possible electrophysiological molecular mechanisms by examining vivo hippocampal long-term potentiation (LTP), central inflammatory responses, JNK/p38/ERK signal pathway....
Background: Alzheimer’s disease (AD) is a neurodegenerative characterized by progressive decline in cognitive function. Type 2 diabetes mellitus (T2DM) an important risk factor for AD. Glucose-dependent insulinotropic polypeptide (GIP) has been identified to be effective T2DM treatment and neuroprotection. Objective: The present study investigated the neuroprotective effects possible mechanisms of DAla2GIP-Glu-PAL, novel long-lasting GIP analogue, APP/PS1 AD mice. Methods: Multiple...
Adult neurogenesis in the dentate gyrus plays a role adaptive brain functions such as memory formation. Adding new neurons to specific locus of neural circuit with functional needs is an efficient way achieve function. However, it unknown whether linked local demands potentially specified by activity neuronal circuits. By examining distribution and different types freely moving adult rats, we find that positionally associated active excitatory neurons, some which show place-cell activity,...
Remembering what just happened is a crucial prerequisite to form long-term memories but also for establishing and maintaining working memory. So far there no general agreement about cortical mechanisms that support short-term Using classifier-based decoding approach, we report hippocampal activity during few sparsely distributed brief time intervals contains information the previous sensory motor experience of rodents. These are characterized by only small increase firing rate neurons....
Remembering what just happened is a crucial prerequisite to form long-term memories but also for establishing and maintaining working memory. So far there no general agreement about cortical mechanisms that support short-term Using classifier-based decoding approach, we report hippocampal activity during few sparsely distributed brief time intervals contains information the previous sensory motor experience of rodents. These are characterized by only small increase firing rate neurons....
<title>Abstract</title> Background Alzhermer’s disease (AD) is a neurodegenerative characterized by progressive decline in cognitive function and high-density deposition of amyloid-β (Aβ) plaques the brain. Type 2 diabetes mellitus (T2DM) an important risk factor for AD. Glucose-dependent insulinotropic polypeptide (GIP) has been identified to be effective T2DM treatment neuroprotection. The present study further investigated neuroprotective effects novel long lasting GIP analogue...