A5045944348- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- CRISPR and Genetic Engineering
- Neurogenesis and neuroplasticity mechanisms
- Virus-based gene therapy research
- Neural dynamics and brain function
- Sleep and Wakefulness Research
- RNA Interference and Gene Delivery
- Neuroscience and Neural Engineering
- Photoreceptor and optogenetics research
- Cellular Automata and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Axon Guidance and Neuronal Signaling
- Viral Infections and Immunology Research
- Gene Regulatory Network Analysis
- S100 Proteins and Annexins
- Retinal Development and Disorders
- Single-cell and spatial transcriptomics
- RNA Research and Splicing
Norwegian University of Science and Technology
2011-2025
Kavli Institute for Systems Neuroscience
2018-2022
Accurate anatomical characterizations are necessary to investigate neural circuitry on a fine scale, but for the rodent claustrum complex (CLCX), this has yet be fully accomplished. The CLCX is generally considered comprise two major subdivisions, (CL) and dorsal endopiriform nucleus (DEn), regional boundaries these areas debated. To address this, we conducted multifaceted analysis of fiber- cytoarchitecture, genetic marker expression, connectivity using mice both sexes, create comprehensive...
Although a variety of remarkable molecular tools for studying neural circuits have recently been developed, the ability to deploy them in particular neuronal subtypes is limited by fact that native promoters are almost never specific enough. We showed one can generate transgenic mice with anatomical specificity surpassing combining enhancers uniquely active brain regions heterologous minimal promoter, an approach we call EDGE (Enhancer-Driven Gene Expression). Here extend this strategy...
Fan cells in layer II of the lateral entorhinal cortex (LEC) form a main component projection to dentate gyrus, CA3 and CA2 hippocampal formation. This has counterpart originating from stellate medial (MEC). Available evidence suggests that two pathways carry different information, exemplified by difference spatial tuning LEC MEC. The grid cell, prominent position-modulated cell type present MEC, been postulated derive its characteristic hexagonal firing pattern dominant disynaptic...
The entorhinal cortex, in particular neurons layer V, allegedly mediate transfer of information from the hippocampus to neocortex, underlying long-term memory. Recently, this circuit has been shown comprise a hippocampal output recipient Vb and cortical projecting Va. With use vitro electrophysiology transgenic mice specific for Vb, we assessed presence thus necessary connection Vb-to-Va functionally distinct medial (MEC) lateral (LEC) subdivisions; MEC, particularly its dorsal part,...
Accurate anatomical characterizations are necessary to investigate neural circuitry on a fine scale, but for the rodent claustrum complex (CC) this has yet be fully accomplished. The CC is generally considered comprise two major subdivisions, (CL) and dorsal endopiriform nucleus (DEn), regional boundaries these areas highly debated. To address this, we conducted multifaceted analysis of fiber- cyto-architecture, genetic marker expression, connectivity using mice both sexes, create...
Adult neurogenesis in the dentate gyrus plays a role adaptive brain functions such as memory formation. Adding new neurons to specific locus of neural circuit with functional needs is an efficient way achieve function. However, it unknown whether linked local demands potentially specified by activity neuronal circuits. By examining distribution and different types freely moving adult rats, we find that positionally associated active excitatory neurons, some which show place-cell activity,...
To extract behaviorally relevant information from our surroundings, brains constantly integrate and compare incoming sensory with those stored as memories. Cortico-hippocampal interactions could mediate such interplay between processing memory recall1-4 but this remains to be demonstrated. Recent work parsing entorhinal cortex-to-hippocampus circuitry show its role in episodic formation5-7 spatial navigation8. However, the organization function of hippocampus-to-cortex back-projection...
Summary Understanding brain function requires understanding neural circuits at the level of specificity which they operate. While recent years have seen development a variety remarkable molecular tools for study circuits, their utility is currently limited by inability to deploy them in specific elements native i.e. particular neuronal subtypes. One can obtain degree with neuron-specific promoters, but promoters are almost never sufficiently restricting this approach transgenic animals. We...
Accurate investigations of neural circuitry require specific genetic access to individual circuit elements, i.e., the myriad neuronal cell-types in brain. However, native promoters cannot achieve this because while most genes are expressed brain, few a single cell-type. We recently used enhancers, subcomponents transcriptional apparatus which tell when and where express, combined with heterologous minimal increase specificity transgene expression, an approach we call Enhancer-Driven Gene...
While a variety of remarkable molecular tools for studying neural circuits have recently been developed, the ability to deploy them in particular neuronal subtypes is limited by fact that native promoters are almost never specific enough. We showed one can generate transgenic mice with anatomical specificity surpassing combining enhancers uniquely active brain regions heterologous minimal promoter, an approach we call EDGE (Enhancer-Driven Gene Expression). Here extend this strategy...
All brain functionality arises from the activity in neural circuits different anatomical regions. These regions contain comprising unique cell types. An integral part to understanding is a full census of constituent parts, i.e., This can be based on characteristics. Previously combinations morphology and physiology, gene expression, chromatin accessibility have been used various cortical subcortical has given an extensive yet incomplete overview However, these techniques not applied all Here...
SUMMARY Understanding neural circuit function requires individually addressing their component parts: specific neuronal cell types. However, not only do the precise genetic mechanisms specifying types remain obscure, access to these by transgenic techniques also remains elusive. While most genes are expressed in brain, vast majority many different kinds of neurons, suggesting that promoters alone sufficiently distinguish there orders magnitude more distal cis-regulatory elements controlling...
Summary The entorhinal cortex, in particular neurons layer V, allegedly mediate transfer of information from the hippocampus to neocortex, underlying long-term memory. Recently, this circuit has been shown comprise a hippocampal output recipient Vb and cortical projecting Va. With use vitro electrophysiology transgenic mice specific for Vb, we assessed presence thus necessary connection Vb-to-Va functionally distinct medial (MEC) lateral (LEC) subdivisions; MEC, particularly its dorsal part,...