A5101493506- Alzheimer's disease research and treatments
- GDF15 and Related Biomarkers
- Neuroscience and Neuropharmacology Research
- Circadian rhythm and melatonin
- Liver physiology and pathology
- Liver Disease Diagnosis and Treatment
- Biochemical effects in animals
- Nuclear Receptors and Signaling
- Stress Responses and Cortisol
- Diabetes Treatment and Management
- Neurogenesis and neuroplasticity mechanisms
- Bone Metabolism and Diseases
- Neuropeptides and Animal Physiology
- Regulation of Appetite and Obesity
- Memory and Neural Mechanisms
- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Pancreatic function and diabetes
- Immune cells in cancer
Shaoyang University
2013-2024
Shanxi Medical University
2012-2014
Alzheimer's disease (AD), the most prevalent neurodegenerative in elderly, leads to progressive loss of memory and cognitive deficits. Amyloid-β protein (Aβ) brain is thought be main cause AD. Melatonin, an indole hormone secreted by pineal gland, has been reported produce neuroprotective effects. We examined whether melatonin could protect Aβ-induced impairments hippocampal synaptic plasticity, neuronal cooperative activity, learning memory. Rats received bilateral intrahippocampal...
Amyloid β peptide (Aβ) has been thought to be neurotoxic and responsible for the impairment of learning memory in Alzheimer's disease (AD). Humanin (HN), a 24 amino acid polypeptide first identified from unaffected occipital lobe an AD patient, is believed neuroprotective against AD-related neurotoxicity. In this study, we investigated effects Colivelin (CLN), novel HN derivative, Aβ by using behavioral test, vivo electrophysiological recording, intracellular calcium imaging. Our results...
Rattin, a specific derivative of humanin in rats, shares the ability with HN to protect neurons against amyloid β (Aβ) peptide-induced cellular toxicity. However, it is still unclear whether Rattin can Aβ-induced deficits cognition and synaptic plasticity rats. In present study, we observed effects Aβ31-35 on spatial reference memory vivo hippocampal Long-term potentiation rats by using Morris water maze test field potential recording. Furthermore, probable molecular mechanism underlying...
To assess the effect of omega-3 polyunsaturated fatty acids (n-3 PUFA) on liver regeneration rats with cirrhosis after hepatectomy and antifibrosis.Omega-3 were intravenously injected in n-3 PUFA group 3 days before operation to 1 day partial hepatectomy. 70% was performed rats, which subsequently divided into 4 groups, namely normal (PH); (LC+PH); cirrhosis, (1 mL/kg), (LC+n-3 PUFA+PH); (2 mL/kg) (LC+n-3PUFA*+PH). Body/liver weight ratios, serum parameters, histopathological examination,...
The tuberal nucleus (TN) is a hypothalamic region which well described in humans but remains poorly defined rodents. In this paper, the authors demonstrated by specific and sophisticated techniques role of somatostatin expressing TN (TNSST) neurons control food intake mice. Interestingly, their results showed TNSTT as compared to SST located arcuate nucleus. Furthermore, that appetite-promoting hormone, ghrelin, induced robust activation TNSST both in-vivo slices. They then confirmed those...
Objective To investigate the correlation of hippocampal synaptic plasticity with spatial learning and memory under normal pathological condition, provide experimental evidence for coincidence late-phase long-term potentiation (L-LTP) behavioral experiments. Methods 38 SD rats were randomly divided into two groups, control AD model. First, Morris water maze was used to test ability rats. The escape latencies search an underwater platform in 5 days navigation tests swimming time...