A5100387500- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Reproductive biology and impacts on aquatic species
- Virus-based gene therapy research
- Animal Genetics and Reproduction
- Animal Behavior and Reproduction
- Cleft Lip and Palate Research
- CAR-T cell therapy research
- Nutrition, Genetics, and Disease
- Craniofacial Disorders and Treatments
- MicroRNA in disease regulation
- Genetics and Neurodevelopmental Disorders
- Autism Spectrum Disorder Research
- Obstructive Sleep Apnea Research
- RNA Interference and Gene Delivery
- Estrogen and related hormone effects
- SARS-CoV-2 and COVID-19 Research
- Cancer Genomics and Diagnostics
- Cancer Research and Treatments
- Cell death mechanisms and regulation
- Neurogenesis and neuroplasticity mechanisms
- Reconstructive Surgery and Microvascular Techniques
- Genomics and Chromatin Dynamics
- Genomic variations and chromosomal abnormalities
- Gender Studies in Language
- Nasal Surgery and Airway Studies
National Engineering Research Center for Information Technology in Agriculture
2023
Zhengzhou University
2023
China-US (Henan) Hormel Cancer Institute
2023
Zhejiang University
2023
Harbin Medical University
2022
Army Medical University
2020
University of Otago
2015-2019
Wuhan University
2002-2018
Renmin Hospital of Wuhan University
2018
Eastern Hepatobiliary Surgery Hospital
2017
Ovary-to-testis transformation in a sex-changing fish involves transcriptomic and epigenomic reprogramming.
Teleost fishes exhibit remarkably diverse and plastic sexual developmental patterns. One of the most astonishing is rapid socially controlled female-to-male (protogynous) sex change observed in bluehead wrasses (Thalassoma bifasciatum). Such functional widespread marine fishes, including species commercial importance, yet its underlying molecular basis remains poorly explored. RNA sequencing was performed to characterize transcriptomic profiles identify genes exhibiting sex-biased expression...
Phenotypic plasticity represents an elegant adaptive response of individuals to a change in their environment. Bluehead wrasses (Thalassoma bifasciatum) exhibit astonishing sexual plasticity, including female-to-male sex and discrete male morphs that differ strikingly behavior, morphology, gonadal investment. Using RNA-seq transcriptome profiling, we examined the genes physiological pathways underlying flexible behavioral differences among female, dominant (bourgeois) male, female-mimic...
Fishes exhibit remarkably diverse, and plastic, patterns of sexual development, most striking which is sequential hermaphroditism, where individuals readily reverse sex in adulthood. How this stunning example phenotypic plasticity controlled at a genetic level remains poorly understood. Several genes have been implicated regulating change, yet the degree to conserved machinery orchestrates process has not addressed. Using captive in-the-field social manipulations initiate combined with...
A safe and effective vaccine is urgently needed to control the unprecedented COVID-19 pandemic. Four adenovirus-vectored vaccines expressing spike (S) protein have been approved for use. Here, we generated several recombinant chimpanzee adenovirus (AdC7) S, receptor-binding domain (RBD), or tandem-repeat dimeric RBD (RBD-tr2). We found vaccination via either intramuscular intranasal route was highly immunogenic in mice elicit both humoral cellular immune responses. AdC7-RBD-tr2 showed higher...
Abstract Solenopsis invicta Buren, also known as the red imported fire ant (RIFA), has had a very negative effect on biological diversity, public safety, agriculture, and economics. Because of growth in global trade, RIFA threat to China will continue increase. To better understand characteristics newly observed distributions RIFA, we studied effects three factors including provincial areas, landcover types, climatic conditions 130 new occurrence records 2021. (1) We found that preferred...
The aim of the study was to evaluate efficacy buccal fat pad (BFP) in reconstruction various intraoral maxillary defects as well success, anatomy, healing process, merits, demerits, and complications this technique.The conducted Oral Maxillofacial Surgery Department First Affiliated Hospital Xinjiang Medical University, China, between 2007 2013. BFP used a pedicled graft small medium-sized patients (18 men 9 women) ranging age from 2 70 years (mean age, 36 y). criterion taken for successful...
Objective: To estimate the cleft lip with or without palate (CL/P) prevalence among births between 2006 and 2012 in Fangshan district of Beijing, China. Design: Surveillance data analysis. Setting: All hospitals that provide obstetric services district. Patients: The CL/P cases presented for this report were from 13 weeks’ gestation to 7 days postpartum. Main Outcome Measures: was defined as number per 10 000 births, including live stillbirths at 28 beyond. Results: overall 18.9 (95%...
Targeting cancer stem cells with oncolytic virus (OV) holds great potential for thorough elimination of cells.Based on our previous studies, we here established 11R-P53 and mGM-CSF carrying adenovirus (OAV) SG655-mGMP investigated its therapeutic effect hepatocellular carcinoma Hep3B-C teratoma ECCG5.Firstly, the augmenting 11R in construct was tested confirmed by examining expression EGFP Fluorescence FCM assays after transfecting ECCG5 OVA SG7605-EGFP SG7605-11R-EGFP.Secondly, expressions...
Abstract Bluehead wrasses undergo dramatic, socially-cued female to male sex change. We apply transcriptomic and methylome approaches in this wild coral reef fish identify the primary trigger subsequent molecular cascade of gonadal metamorphosis. Our data suggest that environmental stimulus is exerted via stress axis, repression aromatase gene (encoding enzyme converting androgens estrogens) triggers a cascaded collapse feminizing expression, identifies notable sex-specific...
// Faheem Ahmed Khan 1 , Hui Liu Hao Zhou Kai Wang Muhammad Tahir Ul Qamar 2 Nuruliarizki Shinta Pandupuspitasari 1, 3 and Zhang Shujun Key Laboratory of Agricultural Animal Genetics, Breeding Reproduction, Ministry Education China, College Science Technology Huazhong University, Wuhan, China Informatics, The Center for Biomedical Research, Tongji Hospital, Medical College, University Technology, Correspondence to: Shujun, email: sjxiaozhang@mail.hzau.edu.cn Keywords: spermatogenesis,...
Johnston and Hunter (1989) reported that in monozygotic twins discordant for cleft lip +/- palate, the noncleft demonstrated what appeared to be a bimodal distribution of nasal cavity width. Two thirds showed reduced airway size one third normal or slightly greater size. They suggested two-thirds group may represent medial prominences other underdevelopment maxillary prominence. We were particularly interested findings because difference differences pathogenesis therefore have etiologic...
In order to determine the human foamy virus (HFV) infection in vitro conveniently, we developed a baby hamster kidney cell (BHK)-21-derived indicator line (BHK-HFVLTR-EGFP) containing plasmid that encodes enhanced green fluorescent protein (EGFP) driven by HFV long terminal repeat promoter. The viral trans-activator Bel-1 can induce EGFP expression, so titer could be determined counting corresponding EGFP-positive cells. This foamy-virus-activated expression (FAE) assay was about 50 times...
‘Wreckfish’ a collective of species belonging to the family Polyprionidae, are an important commercial fishery and have significant aquaculture potential. Until now, genomic or transcriptomic information for any within genus Polyprion has either remained unpublished is non-existent. Using Illumina HiSeq, we compared transcriptomes hāpuku (Polyprion oxygeneios) ovaries explore developmental stage-specific variations underlying their reproductive physiology. We sought identify differentially...
Erectile dysfunction (ED) is a multifactorial disorder that can cause significant distress for men. Risk factor identification may allow future ED prevention or delay onset. The goal of this investigation is: 1) to evaluate different machine learning approaches prognosticating and, 2) analyze the degree importance risk factors. investigated include: logistic regression as statistical method, multilayer feedforward backpropagation neural networks (an artificial neural-network tool), 3) fuzzy...
Johnston and Hunter (1989) reported that in monozygotic twins discordant for cleft lip ± palate, the noncleft demonstrated what appeared to be a bimodal distribution of nasal cavity width. Two thirds showed reduced airway size one third normal or slightly greater size. They suggested two-thirds group may represent medial prominences other underdevelopment maxillary prominence. We were particularly interested findings because difference differences pathogenesis therefore have etiologic...
Fishes exhibit remarkably diverse, and plastic, patterns of sexual development, most striking which is sequential hermaphroditism, where individuals readily reverse sex in adulthood. How this stunning example phenotypic plasticity controlled at a genetic level remains poorly understood. Several genes have been implicated regulating change, yet the degree to conserved machinery orchestrates process has not addressed. Using captive in-the-field social manipulations initiate combined with...