A5065044167- vaccines and immunoinformatics approaches
- Computational Drug Discovery Methods
- Coconut Research and Applications
- Advanced Photocatalysis Techniques
- SARS-CoV-2 and COVID-19 Research
- Monoclonal and Polyclonal Antibodies Research
- TiO2 Photocatalysis and Solar Cells
- Gas Sensing Nanomaterials and Sensors
- Transgenic Plants and Applications
- Immunotherapy and Immune Responses
- Chromosomal and Genetic Variations
- Genomics and Phylogenetic Studies
- Corporate Finance and Governance
- Plant tissue culture and regeneration
- Biochemical and Structural Characterization
- Viral Infections and Outbreaks Research
- Advanced Nanomaterials in Catalysis
- CRISPR and Genetic Engineering
- Mosquito-borne diseases and control
- Bioinformatics and Genomic Networks
- Viral Infections and Vectors
- Plant Virus Research Studies
- Antenna Design and Analysis
- Photosynthetic Processes and Mechanisms
- Plant Gene Expression Analysis
Government College University, Faisalabad
2013-2025
Queen Mary University of London
2023-2025
Guangxi University
2020-2025
Huazhong Agricultural University
2016-2025
Forman Christian College
2018-2025
State Key Laboratory For Conservation and Utilization of Subtropical Agro-Bioresources
2020-2023
COMSATS University Islamabad
2016-2023
Higher Colleges of Technology
2021-2023
University of California, Riverside
2022
University of Agriculture Faisalabad
2015-2021
The recent pandemic of coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 has raised global health concerns. viral 3-chymotrypsin-like cysteine protease (3CLpro) enzyme controls replication and is essential for its life cycle. 3CLpro a proven drug discovery target in the case severe acute respiratory syndrome (SARS-CoV) Middle East (MERS-CoV). Recent studies revealed that genome sequence very similar to SARS-CoV. Therefore, herein, we analysed sequence, constructed 3D homology model,...
Abstract Background Middle East Respiratory Syndrome Coronavirus (MERS-COV) is the main cause of lung and kidney infections in developing countries such as Saudi Arabia South Korea. This infectious single-stranded, positive (+) sense RNA virus enters host by binding to dipeptidyl-peptide receptors. Since no vaccine yet available for MERS-COV, rapid case identification, isolation, infection prevention strategies must be used combat spreading MERS-COV infection. Additionally, there a desperate...
A nanocomposite composed of rGO and γ-Fe2O3 was prepared using ultrasonication for the adsorption malachite green (MG) dye. The preferential plane diffractions at 2θ values 35.54° 26.45° about (311) (002) with 19.85 20.92 nm crystallite sizes, respectively confirmed successful formation nature adsorbent. Moreover, XPS FTIR results also composite due to existence peaks relevant composite's components. adsorbent's surface charge (pHPZC = ~ 7.1) estimated salt addition technique. To minimize...
CuO@ZnO core-shell catalysts, coated by varying the CuO layer density ranging from 0.5% to 10%, were synthesized with aim enhance photocatalytic activity of ZnO in sunlight and control its photocorrosion. Initially, Cu(2+) ions impregnated on presynthesized wet impregnation finally converted layers calcination. The optical structural characterization powders was performed DRS, PL, Raman spectroscopy, XRD analysis, respectively. homogeneity explored FESEM. investigated for degradation...
Coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory coronavirus 2 (SARS-COV-2) is a significant threat to global health security. Till date, no completely effective drug or vaccine available cure COVID-19. Therefore, an against SARS-COV-2 crucially needed. This study was conducted design multiepitope based (MEV) SARS-COV-2. Seven highly antigenic proteins of were selected as targets and different epitopes (B-cell T-cell) predicted. Highly overlapping shortlisted....
Abstract Emergence of Dengue as one the deadliest viral diseases prompts need for development effective therapeutic agents. virus (DV) exists in four different serotypes and infection caused by serotype predisposes its host to another DV heterotypic re-infection. We undertook virtual ligand screening (VLS) filter compounds against that may inhibit inclusively all serotypes. Conserved non-structural protein targets such NS1, NS3/NS2B NS5, which play crucial role replication, cycle...
The SARS-CoV-2 was confirmed to cause the global pandemic of coronavirus disease 2019 (COVID-19). 3-chymotrypsin-like protease (3CLpro), an essential enzyme for viral replication, is a valid target combat SARS-CoV and MERS-CoV. In this work, we present structure-based study identify potential covalent inhibitors containing variety chemical warheads. targeted Asinex Focused Covalent (AFCL) library screened based on different reaction types were identified. addition, FDA-approved find...
The spike protein receptor binding domain (S-RBD) is a necessary corona-viral for and entry of coronaviruses (COVs) into the host cells. Hence, it has emerged as an attractive antiviral drug target. Therefore, present study was aimed to target severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) S-RBD with novel bioactive compounds retrieve potential candidates that could serve anti-coronavirus disease 2019 (COVID-19) drugs. In this paper, computational approaches were employed,...
Medicinal plants are the main natural pools for discovery and development of new drugs. In modern era computer-aided drug designing (CADD), there is need prompt efforts to design construct useful database management system that allows proper data storage, retrieval with user-friendly interface. An inclusive having information about classification, activity ready-to-dock library medicinal plant's phytochemicals therefore required assist researchers in field CADD. The present work was designed...
Abstract Background Coronavirus disease 2019 (COVID-19) linked with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cause illness and life-threatening pneumonia in humans. The current COVID-19 pandemic demands an effective vaccine to acquire protection against the infection. Therefore, present study was aimed design a multiepitope-based subunit (MESV) COVID-19. Methods Structural proteins (Surface glycoprotein, Envelope protein, Membrane glycoprotein) of SARS-CoV-2 are...
Respiratory syncytial virus (RSV) is primarily associated with respiratory disorders globally. Despite the availability of information, there still no competitive vaccine available for RSV. Therefore, present study has been designed to develop a multiepitope-based subunit (MEV) using reverse vaccinology approach curb RSV infections. Briefly, two highly antigenic and conserved proteins (glycoprotein fusion protein) were selected potential epitopes different categories (B-cell T-cell)...
Abstract Background Coconut is an important tropical oil and fruit crop whose evolutionary position renders it a fantastic species for the investigation of evolution monocot chromosomes subsequent differentiation ancient plants. Results Here, we report assembly annotation reference-grade genomes Cn. tall dwarf , genome sizes are 2.40 Gb 2.39 Gb, respectively. The comparative analysis reveals that two coconut subspecies diverge about 2–8 Mya while conserved Arecaceae-specific whole-genome...
Antibiotic resistance (AR) is the mechanism pattern in bacteria that evolves over some time, thus protecting against antibiotics. AR due to bacterial evolution make itself fit changing environmental conditions a quest for survival of fittest. has emerged misuse and overuse antimicrobial drugs, few antibiotics are now left deal with these superbug infections. To combat AR, vaccination an effective method, used either therapeutically or prophylactically. In current study, silico approach was...
Antibiotic resistance (AR) is the result of microbes' natural evolution to withstand action antibiotics used against them. AR rising a high level across globe, and novel resistant strains are emerging spreading very fast. Acinetobacter baumannii multidrug Gram-negative bacteria, responsible for causing severe nosocomial infections that treated with several broad spectrum antibiotics: carbapenems, β-lactam, aminoglycosides, tetracycline, gentamicin, impanel, piperacillin, amikacin. The A....
Monkeypox virus (MPXV) outbreaks have been reported in various countries worldwide; however, there is no specific vaccine against MPXV. In this study, therefore, we employed computational approaches to design a multi-epitope Initially, cytotoxic T lymphocyte (CTL), helper (HTL), linear B lymphocytes (LBL) epitopes were predicted from the cell surface-binding protein and envelope A28 homolog, both of which play essential roles MPXV pathogenesis. All evaluated using key parameters. A total 7...
Monkeypox is a viral zoonotic disease that caused by the monkeypox virus (MPXV) and mainly transmitted to human through close contact with an infected person, animal, or fomites which contaminated virus. In present research work, reverse vaccinology several other bioinformatics immunoinformatics tools were utilized design multi-epitopes-based vaccine against MPXV exploring three probable antigenic extracellular proteins: cupin domain-containing protein, ABC transporter ATP-binding protein...