A5101978997- Plant Molecular Biology Research
- Metal complexes synthesis and properties
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Photosynthetic Processes and Mechanisms
- Circadian rhythm and melatonin
- Proteins in Food Systems
- Plant Stress Responses and Tolerance
- Plant Reproductive Biology
- Plant Gene Expression Analysis
- Meat and Animal Product Quality
- Liver Disease Diagnosis and Treatment
- Plant nutrient uptake and metabolism
- Corneal surgery and disorders
- Genetic Mapping and Diversity in Plants and Animals
- MicroRNA in disease regulation
- Dermatologic Treatments and Research
- Ruminant Nutrition and Digestive Physiology
- Ziziphus Jujuba Studies and Applications
- Chromosomal and Genetic Variations
- High Altitude and Hypoxia
- Genetic and phenotypic traits in livestock
- Allelopathy and phytotoxic interactions
- Monoclonal and Polyclonal Antibodies Research
- Fatty Acid Research and Health
Guangdong Ocean University
2025
Nanjing Drum Tower Hospital
2023-2024
Harbin University of Commerce
2022-2024
Gansu Provincial Center for Disease Control and Prevention
2024
Shandong Provincial Hospital
2021-2023
Beijing University of Chinese Medicine
2021-2023
Yancheng Third People's Hospital
2023
Affiliated Hospital of Jining Medical University
2018-2023
Henan Agricultural University
2016-2022
Wuhan Polytechnic University
2022
The biological functions of WRKY transcription factors in plants have been widely studied, but their roles abiotic stress are still not well understood. We isolated an ABA overly sensitive mutant, abo3, which is disrupted by a T-DNA insertion At1g66600 encoding factor AtWRKY63. mutant was hypersensitive to both seedling establishment and growth. However, stomatal closure less ABA, the abo3 drought tolerant than wild type. Northern blot analysis indicated that expression ABA-responsive...
Summary Two allelic Arabidopsis mutants, leaf wilting 2‐1 and 2‐2 ( lew2‐1 lew2‐2 ), were isolated in a screen for plants with altered drought stress responses. The mutants more tolerant to as well NaCl, mannitol other osmotic stresses. lew2 mutant accumulated abscisic acid (ABA), proline soluble sugars than the wild type. expression of stress‐inducible marker gene RD29A , synthesis‐related P5CS (pyrroline‐5‐carboxylate synthase) an ABA SDR1 (alcohol dehydrogenase/reductase) was higher...
Abstract In yeast, the interaction of General Control Non‐derepressible 1 (GCN1) with GCN2 enables to phosphorylate eIF2α (the alpha subunit eukaryotic translation initiation factor 2) under a variety stresses. Here, we cloned AtGCN1 , an Arabidopsis homologue GCN1 . We show that directly interacts and is essential for phosphorylation salicylic acid (SA), ultraviolet (UV), cold stress amino deprivation conditions. Two mutant alleles, atgcn1‐1 atgcn1‐2 which are defective in eIF2α, showed...
The phytohormone abscisic acid (ABA) plays an important role in modulating plant growth, development, and stress responses. In a genetic screen for mutants with altered drought responses, we identified ABA-overly sensitive mutant, the abo1 which showed drought-resistant phenotype. mutation enhances ABA-induced stomatal closing increases ABA sensitivity inhibiting seedling growth. are more resistant to oxidative than wild type show reduced levels of transcripts several stress- or...
Abstract Dolichols are long-chain unsaturated polyisoprenoids with multiple cellular functions, such as serving lipid carriers of sugars used for protein glycosylation, which affects trafficking in the endoplasmic reticulum. The biological functions dolichols plants largely unknown. We isolated an Arabidopsis thaliana mutant, lew1 (for leaf wilting1), that showed a leaf-wilting phenotype under normal growth conditions. LEW1 encoded cis-prenyltransferase, when expressed Escherichia coli...
MicroRNAs (miRNAs) regulate gene expression and play critical roles in growth development as well stress responses eukaryotes. miRNA biogenesis plants requires a processing complex that consists of the core components DICER-LIKE 1 (DCL1), SERRATE (SE) HYPONASTIC LEAVES (HYL1). Here we show inactivation functionally redundant members SnRK2 kinases, which are abscisic acid (ABA) osmotic signaling pathways, leads to reduction accumulation under conditions. Further analysis revealed steady state...
Abstract Several long noncoding RNAs (lncRNAs) have been identified in various malignant tumors and determined to contribute the process of tumorigenesis, including that colorectal cancer (CRC). Cancer stem cells (CSCs) demonstrated promote expansion maintain invasion metastasis cells, owing their self‐renewal capacity. However, underlying modulation mechanism CSC‐associated lncRNAs CRC remains largely unclear. Using integrated bioinformatic analysis, we a novel lncRNA (lncRNA‐cCSC1) is...
A new cobalt(II) complex ( 1 ) of 5‐chloro‐8‐hydroxyquinoline was prepared and structurally characterized using infrared spectroscopy, electrospray ionization mass spectrometry, elemental analysis, single‐crystal X‐ray diffraction as well powder diffraction. Its biological activities including DNA binding anticancer activity were investigated. The study suggested that it interacted with calf thymus mainly via an intercalative mode. in vitro screened against a series tumor cell lines the...
Abstract Colorectal cancer is the most common gastrointestinal and causes severe damage to human health. PRDX2 a member of peroxiredoxin family reported have high level expression in colorectal cancer. However, mechanisms by which promotes proliferation are still unclear. Here, results indicated that was upregulated closely correlated with poor prognosis. Functionally, promoted cells. Mechanistically, could bind RPL4, reducing interaction between RPL4 MDM2. These findings demonstrate...
Single-channel seismic (SCS) methods play a crucial role in offshore wind farm assessments, offering rapid and continuous imaging of the subsurface. Conventional SCS often fall short resolution signal completeness, leading to potential misinterpretations geological structures. In this study, we propose application interferometry as powerful tool address these challenges by utilizing multiple reflections that are usually considered noise. First, demonstrate feasibility using approximate...
Abstract Nitrogen (N), phosphorus (P) or potassium (K) deficiency in plants can lead to a decrease amino acid and protein synthesis. However, it is unknown how translation gets repressed during macronutrient deficiencies. Previous research has shown that general control non-depressible 1 (GCN1) cooperate with GCN2 phosphorylate the alpha subunit of eukaryotic initiation factor (eIF2α). In this study, we observed phosphorylation eIF2α under N, P, K deficiencies, which was found be lost gcn1 ....
Summary N ‐linked glycosylation is an essential protein modification that helps folding, trafficking and translocation in eukaryotic systems. The initial process for shares a common pathway with assembly of dolichol‐linked core oligosaccharide. Here we characterize new Arabidopsis thaliana mutant lew3 ( leaf wilting 3 ), which has defect α‐1,2‐mannosyltransferase, homolog ALG11 yeast, transfers mannose to the oligosaccharide last two steps on cytosolic face ER ‐glycan precursor synthesis....
Background: Previously, our group confirmed the presence of a subset cancer stem cells in tissues endometrial carcinoma (ie, human [HuECSCs]). However, mechanisms by which microRNAs regulate growth HuECSCs remain elusive. Methods: We loaded miR-326 onto superparamagnetic iron oxide nanoparticles (miR-326@SPION) and transfected them into HuECSCs. Results: In present study, we found that expression levels members G-protein coupled receptor 91 (GPR91)/signal transducer activator transcription 3...
A zinc(<sc>ii</sc>) complex of HBrQ showed higher <italic>in vitro</italic> antitumor activity. It induced cell apoptosis in BEL-7404 cells via G<sub>2</sub> phase arrest, led to mitochondria dysfunction and activation caspase cascade. The central should play a key role enhance the effect