A5100692009- Metal complexes synthesis and properties
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Metal-Organic Frameworks: Synthesis and Applications
- Magnetism in coordination complexes
- Nanoplatforms for cancer theranostics
- Crystal structures of chemical compounds
- Advanced biosensing and bioanalysis techniques
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and biological activity
- Lanthanide and Transition Metal Complexes
- Protein Interaction Studies and Fluorescence Analysis
- Ferrocene Chemistry and Applications
- Nanoparticle-Based Drug Delivery
- Advanced Nanomaterials in Catalysis
- DNA and Nucleic Acid Chemistry
- Carbon and Quantum Dots Applications
- Drug Transport and Resistance Mechanisms
- Click Chemistry and Applications
- Nanocluster Synthesis and Applications
- Crystallography and molecular interactions
- Photoacoustic and Ultrasonic Imaging
- Synthesis and Biological Evaluation
- RNA Interference and Gene Delivery
- Polyoxometalates: Synthesis and Applications
Guangxi Normal University
2016-2025
Institute of Natural Science
2025
Shanghai Jiao Tong University
2024-2025
Applied Mathematics (United States)
2025
Beijing Academy of Artificial Intelligence
2025
Shanghai Artificial Intelligence Laboratory
2025
Beijing University of Civil Engineering and Architecture
2023-2025
Chongqing Jiaotong University
2022-2024
Dalian University of Technology
2022-2024
Chinese Academy of Sciences
2006-2024
Abstract Herein, we describe an energy balance strategy between fluorescence and photoacoustic effects by sulfur substitution to transform existing hemicyanine dyes (Cy) into optimized NIRF/PA dual ratiometric scaffolds. Based on this scaffold, reported the first dual‐ratio response of nitroreductase probe AS‐Cy‐NO 2 , which allows quantitative visualization tumor hypoxia in vivo. composed a new scaffold thioxanthene‐hemicyanine (AS‐Cy‐1) 4‐nitrobenzene moiety, showed 10‐fold NIRF...
Porphyrins and their derivatives are widely used as photosensitizers sonosensitizers in tumor treatment. Nevertheless, poor water solubility low chemical stability reduce singlet oxygen (1O2) yield and, consequently, photodynamic therapy (PDT) sonodynamic (SDT) efficiency. Although strategies for porphyrin molecule assembly have been developed to augment 1O2 generation, there is scope further improving PDT SDT efficiencies. Herein, we synthesized ordered manganese (SM) nanoparticles with...
Chemodynamic immunotherapy that utilizes catalysts to produce reactive oxygen species (ROS) for killing tumor cells and arousing antitumor immunity has received considerable attention. However, it is still restricted by low ROS production efficiency insufficient immune activation, due intricate redox homeostasis in the microenvironment (TME). Herein, a metalloprotein-like hybrid nanozyme (FeS@GOx) designed situ growth of (ferrous sulfide, FeS) natural enzyme (glucose oxidase, GOx) amplify...
Two G-quadruplex ligands [Pt(L(a))(DMSO)Cl] (Pt1) and [Pt(L(b))(DMSO)Cl] (Pt2) have been synthesized fully characterized. The two complexes are more selective for SK-OV-3/DDP tumor cells versus normal (HL-7702). It was found that both Pt1 Pt2 could be a telomerase inhibitor targeting DNA. This is the first report demonstrating telomeric, c-myc, bcl-2 G-quadruplexes caspase-3/9 preferred to bind with rather than Pt1, which also can induce senescence apoptosis. different biological behavior of...
Highly sensitive detection of proteins is essential to biomedical research as well clinical diagnosis. Here, we develped a novel label-free colorimetric aptasensor based on nicking enzyme assisted signal amplification and DNAzyme for highly protein. The system consists hairpin DNA probe carrying an aptamer sequence target, G-riched containing two segments the recognition cleavage site enzyme, blocker DNA, enzyme. hybridization with prohibits formation activated DNAzymes in absence target....
Four novel copper tetrazole-1-acetic acid (Htza) coordination polymers, namely, {[Cu(tza)2(Htza)2]·2H2O}n (1), [Cu(tza)2]n (2), {[Cu4(tza)4(CH3COO)2(μ3-OH)2(H2O)2]·2H2O}n (3), and {[Cu4(tza)6(μ3-OH)2]·4H2O}n (4), were synthesized as pH-dependent products characterized by elemental analysis, Fourier transform infrared (FT-IR) spectra, electron paramagnetic resonance (EPR), magnetic properties, single-crystal X-ray diffraction studies. In 1, two neighboring ions are bridged carboxylato groups...
Abstract The self‐assembly of highly stable zirconium(IV)‐based coordination cages with aggregation induced emission (AIE) molecular rotors for in vitro bio‐imaging is reported. two cages, NUS‐100 and NUS‐101, are assembled from the trinuclear zirconium vertices flexible carboxyl‐decorated tetraphenylethylene (TPE) spacers. Extensive experimental theoretical results show that emissive intensity can be controlled by restricting dynamics AIE‐active though multiple external stimuli. Because...
Cisplatin is one of the most effective chemotherapeutic agents, although its clinical use limited by severe nephrotoxicity. Multifunctional platform for spatiotemporally controlled delivery cisplatin and multimodal synergistic therapy highly desirable in antitumor research. Herein, first time, an injectable, NIR-II light-modulated thermosensitive hydrogel synthesized through supramolecular self-assembly a conjugated polymer α-cyclodextrin. This intrinsically features NIR responsive...
Water-soluble hyaluronic acid–hybridized polyaniline nanoparticles show effective photothermal ablation of cancer with targeted specificity.
Agents inducing both apoptosis and autophagic death can be effective chemotherapeutic drugs. In our present work, we synthesized two organometallic gold(III) complexes harboring C^N ligands that structurally resemble tetrahydroisoquinoline (THIQ): Cyc-Au-1 (AuL1Cl2, L1 = 3,4-dimethoxyphenethylamine) Cyc-Au-2 (AuL2Cl2, L2 methylenedioxyphenethylamine). screening their in vitro activity, found gold exhibited lower toxicity, resistance factors, better anticancer activity than those of...
Dual functionalized natural biomass carbon dots from lychee exocarp were fabricated for cancer cell targetable near-infrared fluorescence imaging and photodynamic therapy.
Malignant melanoma is a highly aggressive tumor resistant to chemotherapy. Therefore, the development of new effective therapeutic agents for treatment malignant desirable. In this study, class polymeric photothermal based on poly( N ‐phenylglycine) (PNPG) suitable use in near‐infrared (NIR) phototherapy designed and developed. PNPG obtained via polymerization ‐phenylglycine (NPG). Carboxylate functionality NPG allows building multifunctional systems using covalent bonding. This approach...
Tumor microenvironment (TME)-activated cancer imaging and therapy is a key to achieving accurate diagnosis treatment of reducing the side effects. Herein, smart near-infrared carbon dot-metal organic framework MIL-100 (Fe) assemblies are constructed achieve TME-activated chemodynamic-photothermal combined therapy. First, emission dot (RCDs) developed using glutathione (GSH) as precursor. Then, RCDs@MIL-100 self-assemblies obtained RCDs, FeCl3 , trimesic acid solutions raw materials. After...
Clinical chemotherapeutic drugs have occasionally been observed to induce antitumor immune responses beyond the direct cytotoxicity. Such effects are coined as immunogenic cell death (ICD), representing a "second hit" from host system tumor cells. Although chemo-immunotherapy is highly promising, ICD inducers remain sparse with vague drug–target mechanisms. Here, we report an endoplasmic reticulum stress-inducing cyclometalated Ir(III)–bisNHC complex (1a) new inducer, and based on this...
Twelve new complexes Cu(L1)2–Cu(L12)2 were designed and synthesized to improve their chemotherapeutic properties. They showed considerable antiproliferative activity against T24 cancer cells but lower cytotoxicity human normal HL-7702 WI-38. A mechanism study indicated that Cu(L4)2 Cu(L10)2 reduced Fenton-like Cu+ by glutathione depletion, the resulting catalyzed generation of highly toxic hydroxyl radicals from excess H2O2. Simultaneously, could decrease catalase restrain H2O2 transfer H2O...