The ratiometric fluorescence assay, which can eliminate the external effects, has attracted great attention. In this work, a carbon dot (CD)-based nanohybrid dual-emission system was simply prepared by unique approach of solvothermal treating corn bract and used as fluorescent sensor for Hg2+ detection. Under single excitation, obtained had two emission bands around 470 678 nm, may originate from intrinsic structure CDs chlorophyll-derived porphyrins, respectively. presence Hg2+, at nm could...

The tumor microenvironment–activated Fe-Cu@PANI nanoprobe is used for photoacoustic imaging and photothermal therapy.

A green approach was developed for the preparation of fluorescent carbon dots (CDs) by using lychee seeds as precursors. The CDs performed simple pyrolysis. quantum yield as-prepared 10.6% quinine sulfate reference. were employed fluorescence probes detection methylene blue (MB). This sensing system exhibits excellent sensitivity and selectivity toward MB, a limit 50 mM is achieved. possible application imaging in living cells also explored. inherent cytotoxicity evaluated HepG2 cell, cell...

Dual functionalized natural biomass carbon dots from lychee exocarp were fabricated for cancer cell targetable near-infrared fluorescence imaging and photodynamic therapy.

Phototherapy exhibits significant potential as a novel tumor treatment method, and the development of highly active photosensitizers photothermal agents has drawn considerable attention. In this work, S N atom co-doped carbon dots (S,N-CDs) with an absorption redshift effect were prepared by hydrothermal synthesis lysine,

Tumor microenvironment (TME)-activated cancer imaging and therapy is a key to achieving accurate diagnosis treatment of reducing the side effects. Herein, smart near-infrared carbon dot-metal organic framework MIL-100 (Fe) assemblies are constructed achieve TME-activated chemodynamic-photothermal combined therapy. First, emission dot (RCDs) developed using glutathione (GSH) as precursor. Then, RCDs@MIL-100 self-assemblies obtained RCDs, FeCl3 , trimesic acid solutions raw materials. After...

The accurate diagnosis and targeted therapy of malignant tumors face significant challenges. To address these, an oxidized molybdenum polyoxometalate-copper nanocomposite (Ox-POM@Cu) is designed synthesized here. doping with Cu determines the formation oxygen vacancies, which can increase carrier concentration in Ox-POM@Cu, accelerate electron transfer, enhance redox activity, thus playing efficient catalytic role. presents unique enzymatic functions characterized by a multielement activity...

Based on a target-activated autocatalytic DNAzyme amplification strategy, novel fluorescence sensing platforms were constructed for highly sensitive and selective assay of base excision repair enzyme activity. By using rolling circle (RCA)-coupled cascade, an extremely low detection limit (0.002 U mL−1) was achieved.

Silver/carbon dots (CDs) nanocomposites receive significant attention for diverse applications owing to their unique physical and chemical properties. Herein, a green method is proposed synthesizing silver nanoparticle/N-doped CDs (AgNPs/N-CDs) nanocomposites, wherein the AgNPs are grown on surface of reduced N-CDs derived from Siraitia grosvenorii. The were used as reducing agent stabilizer, no additional stabilizer necessary. as-synthesized AgNPs/N-CDs characterized using...

A multifunctional nanoprobe with singlet oxygen generation that can target tumors and mitochondria was developed for photodynamic therapy of monitoring mitochondrion pH changes in cancer cells by ratiometric fluorescence imaging.

The absolute quantification of miRNAs in a single cell allows to better understand the heterogeneity cells and relationship between diseases. However, seldom methods for miRNA have been reported because content is very low. Herein, an ultrasensitive chemiluminescence assay strategy based on rolling circle amplification (RCA) microchip platform was proposed cell. In this strategy, ring probe with specificity designed synthesized, which could perform RCA target improve sensitivity satisfy need...

Abstract Tumor metastasis remains a leading factor in the failure of cancer treatments and patient mortality. To address this, silver‐induced absorption red‐shifted core‐shell nano‐particle is developed, surface‐modified with triphenylphosphonium bromide (TPP) hyaluronic acid (HA) to obtain novel nanodiagnosis‐treatment agent (Ag@CuS‐TPP@HA). This diagnosis‐treatment can dual‐targets cells mitochondria, exhibits maximal light at 1064 nm, thereby enhancing nesr‐infrared II (NIR‐II)...

We developed a WS2 nanosheet based chemiluminescence resonance energy transfer (CRET) platform for sensing biomolecules. This exhibits high detection sensitivity and specificity target molecules.

Calcium ion (Ca2+) plays crucial roles in the signal transduction pathways associated with various physiological and pathological events. Monitoring intracellular Ca2+ is of great significance for cell biology research. Here, we report use biomass quantum dots (BQDs) as a fluorescent reporter imaging Ca2+, based on inner-filter-mediated luminescence which was assisted by chelator alizarin red S (ARS). BQDs were prepared hydrothermal heating capsicum. The absorption ARS overlaps excitation...

Abstract Hydrogen sulfide (H 2 S) is a vital gaseous signaling molecule that plays central role in various physiological and pathological processes. Given the complementary advantages of fluorescence (FL) photoacoustic (PA) imaging, there growing demand for dual‐ratiometric probes enable precise vivo monitoring H S levels. In this study, use 2‐mercapto‐1,3,4‐thiadiazole (MTD) as novel recognition group presented first time, following conjugation with cyanine dyes to obtain new PA probe...

Sulfur dioxide (SO2) dysmetabolism is closely associated with various diseases such as acute kidney injury (AKI). Nevertheless, the relationship between SO2 levels and iodinated contrast-induced AKI remains largely unclear. Therefore, accurate imaging of level fluctuations in vivo therefore critically important. However, no photoacoustic (PA) method currently available for detection SO2. To address this gap, we designed synthesized a PA probe toward SO2, namely, Rho-QL, first time performed...