A5100421888- Plant Molecular Biology Research
- interferon and immune responses
- Photosynthetic Processes and Mechanisms
- Immune cells in cancer
- Light effects on plants
- Diabetes and associated disorders
- Plant Stress Responses and Tolerance
- Ubiquitin and proteasome pathways
- Hepatitis B Virus Studies
- Calcium signaling and nucleotide metabolism
- Protein Tyrosine Phosphatases
- Crystallization and Solubility Studies
- Mitochondrial Function and Pathology
- Cytokine Signaling Pathways and Interactions
- Plant Genetic and Mutation Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer-related gene regulation
- Microbial Community Ecology and Physiology
- Toxoplasma gondii Research Studies
- Axon Guidance and Neuronal Signaling
- Protein Degradation and Inhibitors
- Hepatitis C virus research
- Genetic Neurodegenerative Diseases
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
Hunan Agricultural University
2012-2024
Ningbo University
2024
Zhengzhou University
2024
Henan Cancer Hospital
2024
University of Pittsburgh
2021
Jackson Laboratory
2016-2019
Tufts University
2019
Purdue University West Lafayette
2017
University of Connecticut
2014
Hunan University
2010
Abstract Glucose metabolism and innate immunity evolved side-by-side. It is unclear if how the two systems interact with each other during hepatitis B virus (HBV) infections and, so, which mechanisms are involved. Here, we report that HBV activates glycolysis to impede retinoic acid-inducible gene I (RIG-I)-induced interferon production. We demonstrate sequesters MAVS from RIG-I by forming a ternary complex including hexokinase (HK). Using series of pharmacological genetic approaches,...
MicroRNAs (miRNAs) regulate gene expression and play critical roles in growth development as well stress responses eukaryotes. miRNA biogenesis plants requires a processing complex that consists of the core components DICER-LIKE 1 (DCL1), SERRATE (SE) HYPONASTIC LEAVES (HYL1). Here we show inactivation functionally redundant members SnRK2 kinases, which are abscisic acid (ABA) osmotic signaling pathways, leads to reduction accumulation under conditions. Further analysis revealed steady state...
The galectin 3 binding protein (LGALS3BP, also known as 90K) is a ubiquitous multifunctional secreted glycoprotein originally identified in cancer progression. It remains unclear how 90K functions innate immunity during viral infections. In this study, we found that infections resulted elevated levels of 90K. Further studies demonstrated expression suppressed virus replication by inducing IFN and pro-inflammatory cytokine production. Upon investigating the mechanisms behind event,...
MAVS is an adapter protein involved in RIG-I-like receptor (RLR) signaling mitochondria, peroxisomes, and mitochondria-associated ER membranes (MAMs). However, the role of glucose metabolism RLR cross-regulation how these pathways are coordinated among organelles have not been defined. This study reports that action drives a switch from glycolysis to pentose phosphate pathway (PPP) hexosamine biosynthesis (HBP) through MAVS. We show peroxisomal responsible for flux shift into PPP type III...
Autoantibodies can be present years to decades before the onset of disease manifestations in autoimmunity. This finding suggests that initial autoimmune trigger involves a peripheral lymphoid component, which ultimately drives pathology local tissues later life. We show Sjögren's syndrome develop aged NOD.H-2h4 mice were driven by and dependent on dysregulation arose early Specifically, elimination spontaneous germinal centers spleens young transient blockade CD40 ligand (CD40L) or...
The shortage of land resources restricts the sustainable development agricultural production. Multiple cropping has been widely used in Southern China, but whether continuous planting will cause a decline soil quality and crop yield is unclear. To test multiple could increase grain yield, we investigated farmlands with different cultivation years (10-20 years, 20-40 >40 years). Results showed that tobacco-rice rotation significantly increased pH, nitrogen nutrient content, it richness...
Tumor-associated macrophages (TAMs) are critical in the tumor microenvironment (TME) of hepatocellular carcinoma (HCC). Major vault protein (MVP) mediates multidrug resistance, cell growth and development, viral immunity. However, relationship between MVP TAMs polarization has not been clarified HCC. We found that significantly increased M2-TAMs infiltration levels tissues HCC patients. promoted proliferation, metastasis, invasion by regulating M2 vivo vitro . Mechanistically, associated...
Aims and Background: To improve understanding of the relationship between schistosome-related enteropathy colorectal carcinoma with particular focus on endoscopic findings clinicopathological characteristics colonic schistosomiasis. Materials Methods: All cases intestinal schistosomiasis diagnosed at West China Hospital, Chengdu, China, October 2006 2012 were included in this study. A total 179 through colonoscopy pathological examinations collected for analysis demographics, symptoms,...
Background: Epigallocatechin-3-gallate (EGCG), which is the principal component of green tea, has been shown to prevent atherosclerosis. However, effect EGCG on atherosclerotic plaque stability remains unknown. Aim: This study aimed assess whether can enhance and investigate underlying mechanisms. Methods: Apolipoprotein E-deficient mice fed a high-fat diet were injected intraperitoneally with (10 mg/kg) for 16 weeks. Cross sections brachiocephalic arteries stained haematoxylin eosin...
Background and Aims Major vault protein (MVP) is up‐regulated during infections with hepatitis B virus (HBV) C (HCV). Here, we found that MVP deficiency inhibited hepatocellular carcinoma (HCC) development induced by diethylnitrosamine, X protein, HCV core. Approach Results Forced expression was sufficient to induce HCC in mice. Mechanistic studies demonstrate the ubiquitin ligase human double minute 2 (HDM2) forms mutual exclusive complexes either interferon regulatory factor (IRF2) or p53....
Abstract Oncogenic RET alteration is an important, tissue-agnostic therapeutic target across diverse cancers. We conducted a first-in-human phase 1 study on SY-5007, potent and selective inhibitor, in patients with -altered solid tumors. Primary endpoints were safety, maximum tolerated dose (MTD), recommended 2 (RP2D). Secondary included pharmacokinetics preliminary anti-tumor activity. A total of 122 enrolled (17 dose-escalation 105 dose-expansion phase), including 91 non-small cell lung...
Abstract The antineoplastic gefitinib has a low aqueous solubility, leading to poor absorption rates. To overcome this problem, microparticles (MP) were prepared using solution‐enhanced dispersion by supercritical fluids (SEDS) with CO 2 and the cosolvents dichloromethane ethanol. results showed that use of SEDS resulted in formation smaller particles rendered usually heterogeneous crystals crude drug pure uniform. Furthermore, reduction MP size increased dissolution rate gefitinib, vitro...
Nuclear protein of the testis (NUT) carcinoma is a rare and highly aggressive malignancy characterized by rearrangement NUT midline family member 1 (NUTM1) gene. Nevertheless, standardized strategies for its diagnosis treatment remain unavailable, underscoring need expert consensus. To address this gap, we conducted systematic review to gather comprehensive information on from five databases: PubMed, Web Science, Embase, Cochrane Library, Ovid Medline. This consensus was collaboratively...
MicroRNAs (miRNAs) are small, non-coding, regulatory RNAs that play important roles in abiotic stress responses plants, but their the adaptive response to heat at booting stage two rice varieties, 9311 and Nagina 22, remain largely unknown. In this study, 464 known miRNAs 123 potential novel were identified. Of these miRNAs, a total of 90 differentially expressed obtained with libraries as control group, which 54 upregulated 36 downregulated. To gain insight into functional significance,...
Background Ovarian cancer (OV) is the second most prevalent gynecological tumor. Recurrent pregnancy loss (RPL) refers to two or more spontaneous abortions. However, molecular mechanisms underlying both OV and RPL remain poorly understood. This article focuses on exploration of common genetic characteristics their mechanisms. Methods The 71 differentially expressed genes associated with 1427 survival were analyzed, among which 7 important in pathogenesis OV. Then stepAIC analysis was...
Proteins containing an expanded polyglutamine tract are neurotoxins. The proteins influence a variety of cellular functions. In Drosophila the GMR-Gal4/UAS expression system has been widely used in eye-based model to study human neurodegenerative diseases. This facilitated isolation and characterization abundant Drosophilagenes that interact with proteins. We express three tract, or alone. Doubling dose these resulted pupal lethality, indicating toxic induced sensitized condition is prone...
Among enteroviruses, echovirus can cause severe illnesses in neonates or infants, with high morbidity and mortality. Autophagy, a central component of host defense mechanisms, function against diverse infections. In the present study, we investigated interplay between autophagy. We demonstrated that infection increases LC3-II expression dose-dependently, accompanied by an increased intracellular LC3 puncta level. addition, induces formation autophagosome. These results suggest autophagy...
Yield is one of the most important quality indexes for crystal produced by high-pressure crystallization such as supercritical antisolvent (SAS) crystallization. In this study, a prediction model yield SAS was proposed in first place. Then, an experiment that prepares citric acid particle conducted through batch device. With help uniform design method, maximum (0.86) obtained under combination process parameters (the initial concentration solution 0.35 g/mL, operating temperature 33°C,...
Abstract β-cell destruction in type 1 diabetes (T1D) is considered a T-cell mediated autoimmune disease, but based on studies the NOD mouse model, B-lymphocytes also play critical pathogenic role. They do so by serving as preferential subset of APC that expand diabetogenic T cells. Immunological tolerance induction mechanisms normally eliminate or inactivate autoreactive are defective mice and T1D patients. We previously mapped faulty B-lymphocyte phenotype to 6.22Mb region Chromosome 4....
Diacylglycerol signaling network is a key mediator of neurovascular injuries after ischemic stroke. As primary target diacylglycerol, the family protein kinase D (PKD) has been implicated in pathological processes involved ischemia-reperfusion stroke, however, its vivo function disease not thoroughly evaluated. This study aims to investigate whether loss PKD activity affects stroke outcomes mice. Homozygous kinase-dead PKD2 knock-in mice (KI) were obtained by intercrossing heterozygous for...