A5100703710- Lung Cancer Treatments and Mutations
- Gastric Cancer Management and Outcomes
- Cancer-related molecular mechanisms research
- Cell Adhesion Molecules Research
- Lung Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Lung Cancer Research Studies
- Medical Imaging and Pathology Studies
- Lymphoma Diagnosis and Treatment
- Cancer Research and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Peptidase Inhibition and Analysis
- Monoclonal and Polyclonal Antibodies Research
- Cancer Genomics and Diagnostics
- Renal Diseases and Glomerulopathies
- Cancer, Lipids, and Metabolism
- Ovarian cancer diagnosis and treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cervical Cancer and HPV Research
- Sarcoma Diagnosis and Treatment
- Ultrasound and Hyperthermia Applications
- interferon and immune responses
- Cancer, Hypoxia, and Metabolism
- Head and Neck Cancer Studies
Liaoning Cancer Hospital & Institute
2025
China Medical University
2010-2025
Third Affiliated Hospital of Sun Yat-sen University
2012-2025
Shandong Provincial QianFoShan Hospital
2023-2024
Shandong First Medical University
2022-2024
Saarland University
2024
Yangzhou University
2024
Beijing University of Chinese Medicine
2024
Wuhan Union Hospital
2024
Shanghai Jiao Tong University
2023
Parkinson disease (PD) is the most common movement disturbance characterized by loss of dopaminergic (DA) neurons in midbrain. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) aberrantly expressed and involved dendritic synapse development. However, role MALAT1 its underlying mechanism PD remain to be defined.The expressions miR-124 were evaluated qRT-PCR. N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mice SH-SY5Y cells subjected N-methyl-4-phenylpyridinium...
Copy Number Alterations (CNAs)-driven genes have gained attention as potential markers for predicting the response to immune checkpoint blockade in cancer treatment. Among them, VPS72 has emerged a promising candidate hepatocellular carcinoma (HCC). However, relationship between and infiltration remains unclear. TIMER analysis was performed identify populations bulk-RNAseq data. Then, we investigated HCC using diverse data sources, including TCGA GEO databases, clinical specimens, animal...
We evaluated the efficacy and safety of modified FOLFOX6 (mFOLFOX6) regimen as a neoadjuvant chemotherapy in gastric cancer patients.Seventy-three patients with T2-T4 or N+ were enroled. Preoperative consisted three cycles mFOLFOX6. The primary end points response rate R0 resection rate. Prognostic factors for overall survival (OS) investigated using univariate multivariate analyses.Sixty-seven (91.8%) completed 3 cycles, grade 3-4 toxicity arising 33.0%. radiology was 45.8%. Sixty-seven...
308 Background: Anti-PD-1 agent plus chemo as first-line therapy for advanced G/GEJ cancer (Checkmate-649) yields OS and PFS benefits compared to alone, indicating synergistic activity between immune checkpoint inhibitors chemo. The combination of anti-PD-1 anti-CTLA-4 has consistently demonstrated higher response rate PD-1 monotherapy but toxicity. Here, we performed this phase Ib/II study evaluate the efficacy safety AK104, a PD-1/CTLA-4 bispecific antibody, combined with XELOX...
Surfactant protein D (SP-D) is a lung-specific proposed to predict clinical outcomes in patients with chronic obstructive pulmonary disease (COPD). However, the changes serum SP-D during acute exacerbation (AECOPD) episodes and relationship of overall severity stable COPD (SCOPD) remain unclear.Serum levels were analyzed three groups, including AECOPD (n=40), SCOPD (n=71), controls (n=60). In group, determined at 1, 5, 14, 30 days post-exacerbation. BODE (body mass index, airflow...
Background Observational studies have indicated a potential association between education and cardiovascular diseases (CVDs). However, uncertainties regarding the causal relationship persist. Therefore, this study aimed to investigate whether higher levels of causally reduce risks CVDs. Methods Employing two-sample Mendelian randomization (MR) design, our examined ten different Utilizing data from IEU Open GWAS database, relevant single nucleotide polymorphisms (SNPs) were identified through...
Aims and Background: To improve understanding of the relationship between schistosome-related enteropathy colorectal carcinoma with particular focus on endoscopic findings clinicopathological characteristics colonic schistosomiasis. Materials Methods: All cases intestinal schistosomiasis diagnosed at West China Hospital, Chengdu, China, October 2006 2012 were included in this study. A total 179 through colonoscopy pathological examinations collected for analysis demographics, symptoms,...
The aim of this study was to investigate the clinical features, immunohistochemistry (IHC), compound mutation, and prognosis patients with non-small cell lung cancer (NSCLC) harboring exon 19 deletion-insertion mutations.This retrospective analysis included 4,666 NSCLC epidermal growth factor receptor (EGFR) mutations in a multi-center from January 2017 December 2020, 69 EGFR deletion-insertions were taken account. Next-generation sequencing (NGS) used detect subtype deletion-insertions....
Objective: The current study explored the expression of KAI1/CD82 and MRP1/CD9 its significance in laryngeal squamous cell carcinoma (LSCC). Methods: levels 100 LSCC tissue specimens, as well 30 para-LSCC non-carcinomatous specimens randomly taken from patients, were assessed using quantitative polymerase chain reaction (Q-PCR) immunohistochemistry correlations with pathological parameters their influence on survival function analyzed. Results: showed basically consistent changes both mRNA...
To investigate the effectiveness of a CTC-based classifier in stratifying stage IB LUAD.Stage LUADs have an approximately 70% 5-year survival rate. The clinical application ACT is controversial due to inconsistent results series trials and few useful guide biomarkers. Thus, there pressing need for robust biomarkers stratify patients define which group would most likely benefit from ACT. Methods: Two hundred twelve LUAD were enrolled divided into 3 independent cohorts. aptamer-modified...
It has been suggested that renin-angiotensin system (RAS) gene polymorphism is involved in the pathogenesis of Henoch-Schönlein purpura (HSP) with conflicting reports. We therefore investigate effect RAS on HSP susceptibility and severity a Chinese cohort. The study included 142 children 218 healthy controls were genotyped for polymorphisms. Significantly, differences T174M-T ACE-D frequency found between patients (p(alleo) = .002, OR(alleo) 2.001; p(alleo) .007, 1.533, respectively). also...
A growing volume of literature has suggested long noncoding RNAs (lncRNAs) as important players in tumor progression. In this study, we aimed to investigate the expression and prognostic value lncRNA LINC00173 (LINC00173) melanoma. was measured 163 paired cancerous noncancerous specimen samples by real-time polymerase chain reaction. The correlations between with clinicopathological characteristics prognosis were analyzed chi-square test, log-rank multivariate survival analysis....
The purpose of this study was to assess the risk factors and clinical characteristics cardiovascular cerebrovascular events in elderly hemodialysis patients.
To determine whether a bidirectional causal relationship exists between major depressive disorder (MDD) and heart failure (HF).
Treatments for young patients with gastric cancer (GC) remain poorly defined, and their effects on survival are uncertain. We aimed to investigate the receipt of chemotherapy by age category (18-49, 50-64, 65-85 years) explore whether differences in matched gains GC.Patients who were histologically diagnosed GC included from a Chinese multi-institutional database Surveillance, Epidemiology, End Results database. There 5,122 31,363 aged 18-85 years treated between 2000 2014, respectively....
CTCs play a critical role in the diagnosis and prognosis of liver cancer. However, there are few studies on whether different types can predict patients with HCC following LT.Retrospective data including detected by CanPatrolTM platform combined RNA-ISH were collected analyzed 56 from December 2016 to 2019 at Third Affiliated Hospital Sun Yat-sen University, Guangzhou, Guangdong Province, China.During study period, fifty-six (51 males, 5 females) included an mean age 52 ± 9 years. The 1-, 2-...
4031 Background: Anti-PD-1 monoclonal antibodies plus chemo as first-line therapy for advanced G/GEJ cancer yields OS and PFS benefits compared to alone while the survival are limited, especially in patients with low PD-L1 expression (CPS<5). Simultaneous blockade of PD-1 CTLA-4 pathways has shown synergistic anti-tumor activity been proven effective across multiple types. This phase Ib/Ⅱ dose-escalation study evaluated safety efficacy AK104, a PD-1/CTLA-4 bispecific antibody, combined...
After androgen ablation therapy (AAT), advanced prostate cancer (Pca) eventually progresses to castration-resistant Pca (CRPC); however, the biomarkers that are used predict its prognosis limited. In this study, serum samples from four patients with were collected at time of initial diagnosis and 3 months after AAT. Proteomic changes analyzed two-dimensional differential in-gel electrophoresis matrix-assisted laser desorption/ionization time-of-flightmass spectrometry. Altogether, nine...