A5072129534- Sepsis Diagnosis and Treatment
- Antifungal resistance and susceptibility
- Immune Response and Inflammation
- Inflammation biomarkers and pathways
- Polyamine Metabolism and Applications
- Immune cells in cancer
- Nosocomial Infections in ICU
- Peptidase Inhibition and Analysis
- Respiratory Support and Mechanisms
- Immune Cell Function and Interaction
- Lipoproteins and Cardiovascular Health
- Clusterin in disease pathology
- Streptococcal Infections and Treatments
- Cancer Immunotherapy and Biomarkers
- Traumatic Brain Injury and Neurovascular Disturbances
- Adrenal Hormones and Disorders
- Lipid metabolism and disorders
- Angiogenesis and VEGF in Cancer
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Epigenetics and DNA Methylation
- Gut microbiota and health
- Neonatal and Maternal Infections
- Nitric Oxide and Endothelin Effects
- Metabolomics and Mass Spectrometry Studies
- Hydrology and Drought Analysis
Children's Hospital of Fudan University
2023-2025
Fudan University
2022-2024
Shanghai Children's Medical Center
2024
Anhui Provincial Children's Hospital
2024
Shanghai Jiao Tong University
2024
Wuhan University
2023
State Key Laboratory of Virology
2023
University of Duisburg-Essen
2023
Nanjing Medical University
2023
Zhejiang Ocean University
2023
Degradation of the endothelial glycocalyx is critical for sepsis-associated lung injury and pulmonary vascular permeability. We investigated whether sulodexide, a precursor synthesis glycosaminoglycans, plays biological role in remodeling improves barrier dysfunction sepsis.The number children with septic shock that were admitted to PICU at Children's Hospital Fudan University who enrolled study was 28. On days one three after enrollment, venous blood samples collected, heparan sulfate,...
<title>Abstract</title> Introduction The plasma lipidome has emerged as an important indicator for assessing host metabolic and immune status in sepsis. While previous studies have largely examined specific lipid class changes adults sepsis, comprehensive investigations into lipidomic alterations pediatric sepsis are limited. This study aimed to characterize the using a metabolomics-based exploratory approach, providing insights pathophysiological mechanisms potential biomarkers. Methods A...
Background Notch signaling is critical for regulating the function of vascular endothelial cells (ECs). However, effect intracellular domain Notch1 (NICD) on EC injury in sepsis remains unclear. Methods We established a cell model dysfunction and induced mouse via lipopolysaccharide (LPS) injection cecal ligation puncture (CLP). Endothelial barrier expression endothelial-related proteins were determined using CCK-8, permeability, flow cytometry, immunoblot, immunoprecipitation assays. The...
Tumor-associated macrophages (TAMs) are critical in the tumor microenvironment (TME) of hepatocellular carcinoma (HCC). Major vault protein (MVP) mediates multidrug resistance, cell growth and development, viral immunity. However, relationship between MVP TAMs polarization has not been clarified HCC. We found that significantly increased M2-TAMs infiltration levels tissues HCC patients. promoted proliferation, metastasis, invasion by regulating M2 vivo vitro . Mechanistically, associated...
Sepsis, defined as life-threatening organ failure induced by a dysregulated host response to infection, is serious public health problem globally.1 Sepsis-related deaths represented 19.7% of globally in 2017, accounting for nearly 11 million.2 Approximately 1.2 million children are diagnosed with sepsis each year globally,3 and it estimated that 0.521 neonates die yearly.4 Early detection critical timely care improving clinical outcomes prognoses. As one the most densely populated countries...
Two independent experiments were performed with three groups each (sepsis control, sepsis, and sepsis apoE23 treatment) to investigate the anti-inflammatory effect of apolipoprotein 23 (apoE23) in a mouse model induced by S. typhimurium. Survival rates; plasma level variations tumor necrosis factor (TNF)-α, interleukin (IL)-6, lipopolysaccharide (LPS); typhimurium colony-forming units spleen tissue; mRNA protein expression levels low-density lipoprotein receptor (LDLR), LDLR-related (LRP),...
Objectives The relationship between adiposity and sepsis has received increasing attention. This study aims to explore the causal life course incidence. Methods Mendelian randomization (MR) method was employed in this study. Instrumental variants were obtained from genome-wide association studies for adiposity, including birth weight, childhood body mass index (BMI), obesity, adult BMI, waist circumference, visceral fat percentage. A meta-analysis of 10,154 cases 454,764 controls used MR...
Abstract Myeloid-derived suppressor cells (MDSCs) expand during sepsis and contribute to the development of persistent inflammation-immunosuppression-catabolism syndrome. However, underlying mechanism remains unclear. Exploring mechanisms MDSCs generation may provide therapeutic targets for improving immune status in sepsis. Here, a mouse model is established by cecal ligation perforation. Bone marrow at different time points are harvested detect proportion search differentially expressed...
<title>Abstract</title> During fungal infection, immune cells adapt their metabolic programs to support specialized anti-fungal effector functions. Nevertheless, the role of this process’s biochemical underpinnings is poorly understood. This study reports that infection drives a switch from glycolysis serine synthesis pathway (SSP) and one-carbon metabolism by inducing interaction spleen tyrosine kinase (SYK) phosphoglycerate dehydrogenase (PHGDH). As result, PHGDH promotes SYK...
Background: High prevalence and mortality of sepsis have been widely reported in pediatric intensive care units (PICUs) around the world. Till now, there's a lack national epidemiological data Mainland China. We carried out this study to reveal prevalence, therapeutic interventions, clinical outcomes other characteristics PICUs China.Methods: In cross-sectional study, point was conducted on 12 days from December 2018 November 2019 (from 9 AM third Wednesday every month next Thursday) 53...