A5004004202- Epigenetics and DNA Methylation
- Genetics and Neurodevelopmental Disorders
- Renal and related cancers
- Circular RNAs in diseases
- Immune Cell Function and Interaction
- MicroRNA in disease regulation
- Thyroid Disorders and Treatments
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer-related gene regulation
- Inflammasome and immune disorders
- Long-Term Effects of COVID-19
- Suicide and Self-Harm Studies
- Hormonal Regulation and Hypertension
- Robotics and Automated Systems
- COVID-19 Clinical Research Studies
- Adrenal Hormones and Disorders
- Extracellular vesicles in disease
- Immunotherapy and Immune Responses
- Allergic Rhinitis and Sensitization
- Air Quality and Health Impacts
- Immune Response and Inflammation
- Blood Pressure and Hypertension Studies
- Neuroscience of respiration and sleep
- RNA Research and Splicing
Children's Hospital of Fudan University
2017-2024
Huaihua University
2023-2024
National Health and Family Planning Commission
2024
Fudan University
2024
Southern Medical University
2024
Guangdong Provincial People's Hospital
2024
Guangdong Academy of Medical Sciences
2024
First Hospital of China Medical University
2020-2023
China Medical University
2020-2023
Duke Medical Center
2009-2012
In the adult population, glioblastoma multiforme is one of most common primary brain tumors encountered. Unfortunately, this highly malignant tumor represents over 50% all types central nervous system gliomas. The vast majority GBMs develops quite rapidly without clinical, radiological, or morphologic evidence a less precursor lesion (primary de novo GBMs), as compared to secondary that develop slowly by progression from diffuse low-grade astrocytomas. These GBM subtypes must be kept in mind...
Rationale: Macrophages play critical roles in the pathogenesis of type 1 diabetes mellitus (T1DM). Circular RNAs (circRNAs) are a novel class endogenous with covalently closed loop structures, implicated various disease processes. However, their impact on macrophage activation and T1DM remains elusive. Methods: circRNA expression profiles peripheral blood mononuclear cells (PBMCs) from children were determined by whole transcriptome microarray. Bioinformatics, quantitative real-time PCR,...
PTPRE-AS1 deficiency aggravates pulmonary inflammation but reduces colitis severity by modulating M2 macrophage activation.
Abstract N 6 -methyladenosine (m A), the most prevalent mRNA modification, has an important function in diverse biological processes. However, involvement of m A allergic asthma and macrophage homeostasis remains largely unknown. Here we show that methyltransferases METTL3 is expressed at a low level monocyte-derived macrophages from childhood patients. Conditional knockout Mettl3 myeloid cells enhances Th2 cell response aggravates airway inflammation by facilitating M2 activation. Loss gain...
Thyroid hormone influences glucose homeostasis through central and peripheral regulations. To date, the link between sensitivity to thyroid hormones prediabetes remains unknown. We aimed investigate association risk of in both general euthyroid populations.Participants with serum free triiodothyronine (FT3), thyroxine (FT4), thyrotropin (TSH) measurements from health checkup programs First Hospital China Medical University were collected. measured parameters representing sensitivities...
Circular RNAs (circRNAs) constitute a class of covalently circular non-coding RNA molecules formed by 5′ and 3′ end back-splicing. The rapid development bioinformatics large-scale sequencing has led to the identification functional circRNAs. Despite an overall upward trend, studies focusing on roles circRNAs in immune diseases remain relatively scarce. In present study, we obtained differential circRNA expression profile based microarray analysis peripheral blood mononuclear cells (PBMCs)...
Rationale:The aryl hydrocarbon receptor (AhR) functions in the regulation of intestinal inflammation, but knowledge underlying mechanisms innate immune cells is limited.Here, we investigated role AhR modulating macrophages inflammatory bowel disease pathogenesis.Methods: The cellular composition lamina propria CD45 + leukocytes a dextran sulfate sodium (DSS)-induced mouse colitis model was determined by single-cell RNA sequencing.Macrophage pyroptosis quantified analysis lactate...
Abstract Exosomes are an important carrier for cell communication. miRNAs in exosomes potential biomarkers and therapeutic targets different types of cancer. However, the role exosomal medulloblastoma (MB) patients is largely unknown. In this study, we reported that there was a higher level miR-130b-3p derived from MB patient plasma compared with healthy control plasma. could transfer to line played suppressor roles proliferation. suppressed tumorigenesis by targeting previously unknown...
<h3>Importance</h3> Maternal thyrotropin levels during gestation have a profound effect on pregnancy outcomes; however, few studies to date evaluated the importance of preconception levels. <h3>Objective</h3> To investigate associations between and outcomes. <h3>Design, Setting, Participants</h3> This population-based cohort study enrolled Chinese women aged 20 49 years from National Free Prepregnancy Checkups Project in China. Participants conceived within 6 months after examination...
Background: Ambient particulate matter with an aerodynamic diameter of ≤2.5 μm (PM2.5) is suggested to act as adjuvant for allergen-mediated sensitization and recent evidence suggests the importance T follicular helper (Tfh) cells in allergic diseases. However, impact PM2.5 exposure its absorbed polycyclic aromatic hydrocarbon (PAHs) on Tfh humoral immunity remains unknown. Objectives: We aimed explore environmental indeno[1,2,3-cd]pyrene (IP), a prominent PAH, model, subsequent pulmonary...
Abstract MAPK pathway-driven tumorigenesis, often induced by BRAF V600E , relies on epithelial dedifferentiation. However, how lineage differentiation events are reprogrammed remains unexplored. Here, we demonstrate that proteostatic reactivation of developmental factor, TBX3, accounts for BRAF/MAPK-mediated dedifferentiation and tumorigenesis. During embryonic development, BRAF/MAPK upregulates USP15 to stabilize which orchestrates organogenesis restraining differentiation. The USP15-TBX3...
Abstract Glioblastoma is universally fatal because of its propensity for rapid recurrence due to highly migratory tumor cells. Unraveling the genomic complexity that underlies this characteristic could provide therapeutic targets would greatly complement current surgical therapy. Using multiple high-resolution screening methods, we identified a single locus, adherens junctional associated protein 1 (AJAP1) on chromosome 1p36 lost or epigenetically silenced in many glioblastomas. We found...
Dysregulation of circRNAs is associated with a variety human diseases; however, its role in childhood asthma undefined.The differential expression profiles were analyzed by microarray. The effects and mechanisms which influence macrophage activation detected quantitative real-time PCR, RNA immunoprecipitation assay, chromatin among others. roles circRNA host gene tested cockroach allergen extract (CRE)-induced murine model.We identified 372 that differentially expressed PBMCs children as...