A5100629522- Bone health and treatments
- Monoclonal and Polyclonal Antibodies Research
- Bone Metabolism and Diseases
- Nanoplatforms for cancer theranostics
- SARS-CoV-2 and COVID-19 Research
- Bone health and osteoporosis research
- Land Use and Ecosystem Services
- Bacteriophages and microbial interactions
- Bone and Joint Diseases
- Hepatitis C virus research
- Asthma and respiratory diseases
- Wildlife-Road Interactions and Conservation
- Hepatitis B Virus Studies
- Immune Cell Function and Interaction
- COVID-19 Clinical Research Studies
- Bone Tissue Engineering Materials
- Cancer-related molecular mechanisms research
- Microbial infections and disease research
- Long-Term Effects of COVID-19
- Periodontal Regeneration and Treatments
- Tendon Structure and Treatment
- TGF-β signaling in diseases
- Mesenchymal stem cell research
- Sustainability and Ecological Systems Analysis
- Immune cells in cancer
Huashan Hospital
2024
Fudan University
2019-2024
Beijing Biocytogen (China)
2024
Yangzhou University
2024
Guangzhou Medical University
2017-2023
Ollscoil na Gaillimhe – University of Galway
2022-2023
Zhongnan Hospital of Wuhan University
2022
Wuhan University
2022
Suzhou Institute of Nano-tech and Nano-bionics
2021-2022
Chinese Academy of Sciences
2021-2022
Abstract Background As the number of patients increases, there is a growing understanding form pneumonia sustained by 2019 novel coronavirus (SARS-CoV-2), which has caused an outbreak in China. Up to now, clinical features and treatment infected with SARS-CoV-2 have been reported detail. However, relationship between coagulation scarcely addressed. Our aim investigate blood function infection. Methods In our study, 94 confirmed infection were admitted Renmin Hospital Wuhan University. We...
Abstract Continual generation of new neural cells from adult stem/progenitor (NPCs) is an important component life-long brain plasticity. However, the intrinsic regulation this process remains poorly defined. Here we report that Wip1 phosphatase, previously studied in oncogenesis, functions as a crucial physiological regulator cell generation. deficiency resulted 90% decrease formation olfactory bulb, accompanied by aberrantly decreased NPC amplification, stem frequency, and self-renewal. At...
Temporomandibular joint osteoarthritis (TMJOA) is a degenerative disease that gradually affects the articular cartilage, synovium, and bone structure. To date, molecular mechanism of TMJOA pathogenesis remains unclear. The aim this study was to explore biological function micro-ribonucleic acid 101a-3p (miR-101a-3p) its role in TMJOA.We detected effect interleukin-1β (IL-1β) on chondrocyte proliferation using Cell Counting Kit-8 (CCK-8) technology. Using quantitative polymerase chain...
Bacteriophage phiYY is currently the only double-stranded RNA (dsRNA) phage that infects Pseudomonas aeruginosa and a potential candidate for therapy. Here we applied RNA-seq to investigate lytic cycle of infecting P. strain PAO1r. About 12.45% (651/5,229) host genes were determined be differentially expressed genes. Moreover, oxidative stress response katB ahpB are upregulated 64- 128-fold after infection, single deletion each gene blocked indicating extremely sensitive stress. On contrary,...
Bio-Oss® and α-calcitonin gene-related peptide (CGRP) are involved in osteogenesis. However, it has remained to be assessed how α-CGRP affects the effect of Bio-Oss. In present study, primary osteoblasts were incubated with α-CGRP, Bio-Oss, α-GGRP-Bio-Oss or mimic-α-CGRP. The proliferation rate, mineralization nodules, alkaline phosphatase (ALP) activity expression osteogenic genes measured by a Cell Counting Kit-8 assay, Alizarin Red-S staining, ALP detection reverse-transcription...
Ecological risks (ERs) are external threats to ecosystem structure and function, the evaluation of ER is valuable for understanding extent disturbance ecosystems by human activities. An objective investigation spatio-temporal characteristics its affecting elements can contribute improvement ecological environment sustainable development regional resources. The Funiu Mountains were chosen as study area, risk index was built using landscape interference separation, spatial–temporal properties...
Antibody–antigen (Ab–Ag) interactions are canonically described by a model that exclusively accommodates noninteraction (0) or reproducible interaction (RI) states, yet this is inadequate to explain often-encountered nonreproducible signals. Here, monitoring diverse experimental systems using peptide–protein hybrid microarray, we observed Ab–probe comprise substantial proportion of antibody-based results. This enabled our discovery and capacity reliably identify (NRIs), as well development...
Pseudomonas aeruginosa is a common opportunistic human pathogen. With the emergence of multidrug-resistant (MDR) clinical infection P. aeruginosa, phage therapy has received renewed attention in treating infections. Moreover, detailed understanding host receptor lytic crucial for selecting proper phages therapy. Here, we describe characterization bacteriophage L5 with double-stranded DNA genome 42,925 bp. The genomic characteristics indicate that belonging to subfamily Autographivirinae. In...
Abstract Background: The Interleukin-1 Receptor Accessory Protein (IL1RAP) is found on cancer cells, stromal and infiltrating immune cells within the tumor microenvironment (TME) of various cancers. It plays an important role in development at stages by activating IL-1 superfamily pathway, thus become interesting target treatment. Methods: We investigated correlation between IL1RAP prognosis through analysis public dataset. An antibody discovery campaign was performed DX2206 identified as...
To investigate the expression level and clinical correlation of
Abstract Summary Appropriate use of FRAX reduces the number people requiring DXA scans, while contemporaneously determining those most at risk. We compared results with and without inclusion BMD. It suggests clinicians to carefully consider importance BMD in fracture risk estimation or interpretation individual patients. Purpose is a widely accepted tool estimate 10-year hip major osteoporotic adults. Prior calibration studies suggest this works similarly bone mineral density (BMD). The...
Hepatitis B virus (HBV) specifically infects hepatocytes, which can cause progressive liver fibrosis and a significantly increased risk of cancer. Multiple studies indicated host genetic, virological, immunological factors could affect the HBV infection. However, underlying mechanism involved in infection remained unclear. Based on analysis gene expression data 124 patients (GEO accession: GSE84044), molecular subgroups infected with hepatitis were identified this study, including C1, C2, C3...
Abstract Background Growing evidence has implicated core-binding factor beta (Cbfb) as a contributor to osteoblast differentiation, which plays key role in fracture healing. Herein, we aimed assess whether Cbfb affects differentiation after fibula fracture. Methods Initially, established conditional knockout mouse model for subsequent studies. Immunohistochemical staining was conducted detect the expression of proliferating cell nuclear antigen (PCNA) and collagen II end. Next, isolated...