A5039680882- Glioma Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Ubiquitin and proteasome pathways
- Protein Degradation and Inhibitors
- RNA Research and Splicing
- Meningioma and schwannoma management
- Cerebrovascular and Carotid Artery Diseases
- Natural Compounds in Disease Treatment
- RNA modifications and cancer
- Boron Compounds in Chemistry
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Circular RNAs in diseases
- Cancer Immunotherapy and Biomarkers
- Cancer Mechanisms and Therapy
- Traumatic Brain Injury and Neurovascular Disturbances
- Histone Deacetylase Inhibitors Research
- Vascular Malformations Diagnosis and Treatment
- Immune cells in cancer
- Renal and related cancers
- Nanoparticle-Based Drug Delivery
- Radiopharmaceutical Chemistry and Applications
Soochow University
2015-2024
First Affiliated Hospital of Soochow University
2015-2024
Loma Linda University
2023
Zhujiang Hospital
2023
Southern Medical University
2023
Wuxi No.2 People's Hospital
2023
Jiangnan University
2023
Soochow University
2022
Yangzhou University
2019
Nerve Centre
2017
Immunotherapy for glioblastoma multiforme (GBM) is limited because of a strongly immunosuppressive tumor microenvironment (TME). Remodeling the immune TME an effective strategy to eliminate GBM immunotherapy resistance. Glioma stem cells (GSCs) are inherently resistant chemotherapy and radiotherapy involved in evasion mechanism. This study aimed investigate effects histone methyltransferases 2 (EHMT2 or G9a) on whether this effect was related changes cell stemness.Tumor-infiltrating were...
Abstract Background Zfx is a zinc finger protein of the Zfy family, whose members are highly conserved in vertebrates. shared transcriptional regulator both embryonic stem cells (ESC) and hematopoietic (HSC), which suggests common genetic basis self-renewal adult cells. The level expression correlates with aggressiveness severity many cancer types, including prostate cancer, breast leukemia. However, importance human glioma largely unknown. In present study, we examined role glioma. Methods...
Circulating tumor cells (CTCs) are an important part of liquid biopsy as they represent a potentially rich source information for cancer diagnosis, monitoring, prognosis, and treatment guidance. It has been proved that the nanotopography interaction between surface CTC detection platforms can significantly improve capture efficiency CTCs, whereas many mature nanostructure substrates have developed based on chemistry materials. In this work, natural biointerface with unique biological...
Glioblastoma is one of the malignant tumors central nervous system with high lethality, disability and low survival rate. Effective induction its death existing challenges. In recent studies, heat shock protein 27 (HSP27) has been shown to be associated ferroptosis; therefore, targeting HSP27 may a potential therapeutic approach for GBM.Immunohistochemistry western blot analysis were used detect expression in GBM tissues. CCK8, plate clone formation assay, EdU proliferation assay cell...
Hematoma clearance has been a proposed therapeutic strategy for hemorrhagic stroke. This study investigated the impact of CX3CR1 (CX3C chemokine receptor 1) activation mediated by r-FKN (recombinant fractalkine) on hematoma resolution, neuroinflammation, and underlying mechanisms involving AMPK (AMP-activated protein kinase)/PPARγ (peroxisome proliferator-activated gamma) pathway after experimental germinal matrix hemorrhage (GMH).A total 313 postnatal day 7 Sprague Dawley rat pups were...
Abstract Inhibitors of programmed cell death ligand 1 (PD-L1) and vascular endothelial growth factor receptor 2 (VEGFR2) are commonly used in the clinic, but they beneficial for only a minority glioblastoma multiforme (GBM) patients. GBM has significant immunosuppressive properties, there many cells dysfunctional effector T tumor microenvironment (TME), which is one important reasons failure clinical treatment GBM. Here, we have identified P21 activated kinase 4 (PAK4) as pivotal immune...
Glioma has been investigated for decades, but the prognosis remains poor because of rapid proliferation, its aggressive potential, and resistance to chemotherapy or radiotherapy. The mammalian target rapamycin (mTOR) is highly expressed regulates cellular proliferation cell growth. MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene transcription translation via up-regulating down-regulating levels miRNAs. This study was conducted explore molecular functions miR-199a-3p in...
// Ting Sun 1, * , Haibin Wu Yanyan Li 1 Yulun Huang Lin Yao Xionghui Chen 2 Xiaoxiao Han Youxin Zhou and Ziwei Du Neurosurgery & Brain Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China Emergency Surgery, These authors have contributed equally to the work Correspondence to: Zhou, email: brain_lab@suda.edu.cn Keywords: targeting delivery, transferrin receptor, glioma stem cells Received: March 15, 2017 Accepted: June 20, Published: August...
ABCG2 is a member of the ATP-binding cassette transporter family, which has been detected in wide variety human aggressive tumors, including glioma stem cells (GSCs), tissues higher grades, and implanted xenografts. Previous research implied that might be associated closely with invasion spread tumors. However, specific roles mechanisms regulating migration GSCs remain unclear. In this study, we aimed to identify effects on by GSCs. Our results showed downregulation protein significantly...
Background: Immune cells recognize tumor antigens presented on major histocompatibility complex class I (MHC-I) molecule. Increase of MHC-I molecular expression makes more susceptible to lysis by immune cells. Methods: Tumor lysate vaccine was prepared damage glioma including cell lines and primary cultured from surgical samples. The enhanced effect histone deacetylase inhibitors (HDACi) observed. expressions pathway molecules were detected flow cytometry western blot after HDACi treatment....
Abstract Bromodomain and extraterminal domain (BET) family proteins are considered to be epigenetic readers that regulate gene expression by recognizing acetyl lysine residues on histones nonhistone chromatin factors have been classified as curative targets for a variety of cancers. Glioma‐initiating cells (GICs), which commit self‐renewal, perpetual proliferation, multidirectional differentiation, vigorous tumorigenicity, sustain the peculiar genetic diversification in GBM patients, thus,...
Glioma stem cells in the quiescent state are resistant to clinical radiation therapy. An almost inevitable glioma recurrence is due persistence of these cells. The high linear energy transfer associated with boron neutron capture therapy (BNCT) could kill and proliferative cells.The present study aimed evaluate effects BNCT on stem/progenitor vitro. damage induced by was assessed using cell cycle progression, apoptotic ratio apoptosis-associated proteins expression.The surviving fraction...
The role of celastrol in the treatment cancer has been an area growing interest. To circumvent issues low solubility, poor bioavailability, and systemic toxicity celastrol, we prepared liposomal using thin-film dispersion method. We characterized particle size, encapsulation efficiency, pharmacological parameters celastrol. drug concentration plasma tissues was measured LC-MS/MS. In addition, sulforhodamine B assay used to determine 50% inhibiting concentration. assessed effects compound...
// Ting Sun 1 , Yanyan Li Yulun Huang Zizhu Zhang 2 Weilian Yang Ziwei Du Youxin Zhou Neurosurgery and Brain Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China Beijing Capture Tech Co., Ltd, Beijing, Correspondence to: Zhou, email: brain_lab@suda.edu.cn Keywords: boron neutron capture therapy, glioma stem cells, target, CD133, bioconjugate Received: January 31, 2016 Accepted: April 26, Published: May 13, ABSTRACT uptake (10) by tumor cells...
Abstract Background Gliomas represent the most common primary malignant brain tumors, yet little is known about molecular pathogenesis of these tumors. The highly-regulated Wnt signal transduction pathway essential for normal developmental processes, and defects in are closely linked to oncogenesis. Dickkopf-1 (DKK-1) a secreted protein that acts as potent inhibitor pathway. aim this study was examine expression profile DKK-1 gene human glioma its association with tumor malignancy. Methods...
Glioma is the most common adult malignant primary brain tumor; however, effect of chemotherapy often limited by drug‑resistance and poor prognosis common. Ring finger protein 138 (RNF138) belongs to E3 ligase family, has significantly higher expression level in glioma tissue than noncancerous tissues. Epithelial-mesenchymal-transition (EMT) a critical role cancer invasion metastasis, ultimately leading increased cell motility resistance genotoxic agents. Extracellular‑signal regulated kinase...
// Long Chen 1, 2, * , Lei Shi 3, Wenhua Wang and Youxin Zhou 1 Department of Neurosurgery, The First Affiliated Hospital Soochow University, Suzhou 215006, P. R. China 2 Traditional Chinese Medicine Kunshan, Nanjing University Medicine, 215300, 3 People's Kunshan with Jiangsu These authors have contributed equally to this work Correspondence to: Shi, email: sl1012002322@126.com Zhou, zhouyxyq2008@sohu.com Keywords: glioma stem cells, demethoxycurcumin, reactive oxygen species, caspase-3,...
The new glioma cell line SHG-139 was established and its phenotype, tumorigenicity, pathological characteristics, derived stem cells SHG139S were studied. Immunohistochemistry used to assess expressions in the patient mouse tumor tissues, SHG-139S. Primary culture performed, proliferation, cycle genetic characteristics assessed. MiRNA (Micro RNA) LncRNA (Long non-coding microarray performed. We found that tissue positive for A2B5 (Glial precursors ganglioside), GFAP fibrillary acidic...