A5053914975- Retinal Imaging and Analysis
- Retinal Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Cardiac electrophysiology and arrhythmias
- Ferroptosis and cancer prognosis
- Autophagy in Disease and Therapy
- Immune cells in cancer
- Monoclonal and Polyclonal Antibodies Research
- Glioma Diagnosis and Treatment
- Cell Adhesion Molecules Research
- Glycosylation and Glycoproteins Research
- Nanoplatforms for cancer theranostics
- Cytokine Signaling Pathways and Interactions
- Cardiac Imaging and Diagnostics
- Cancer Mechanisms and Therapy
- Ubiquitin and proteasome pathways
- Cancer-related molecular mechanisms research
- Glaucoma and retinal disorders
- Cell death mechanisms and regulation
- Galectins and Cancer Biology
- Chemical Thermodynamics and Molecular Structure
- Phonocardiography and Auscultation Techniques
- Endometriosis Research and Treatment
- Thermodynamic and Structural Properties of Metals and Alloys
- Ultrasound and Cavitation Phenomena
Shaanxi Provincial People's Hospital
2025
The Retina Center
2023-2025
University of Washington
2017-2025
Second Affiliated Hospital of Zhejiang University
2025
University of Shanghai for Science and Technology
2024
Shanghai University of Medicine and Health Sciences
2024
Soochow University
2021-2024
First Affiliated Hospital of Soochow University
2021-2024
First Affiliated Hospital of Henan University
2023
Hebei Medical University
2021-2022
Glioma stem cells (GSCs) are the important cause of tumorigenesis, recurrence, and chemo(radio)resistance in glioma. Targeting GSCs helps improve outcomes glioma treatment. Polo-like kinase 1 (PLK1) is a member serine/threonine protein family, which highly conserved. In recent years, it has been suggested that increased levels PLK1 its activity associated with tumor progression poor prognosis. We aimed to identify whether plays critical role stemness maintenance apoptosis regulation GSCs....
Gastric cancer represents a highly lethal malignancy with an elevated mortality rate among patients, coupled suboptimal postoperative survival prognosis. Nectin-4, overexpressed oncological target for various cancers, has been exploited to create antibody-drug conjugates (ADCs) treat solid tumors. However, there is limited research on Nectin-4 ADCs specifically gastric cancer, and conventional immunoglobulin G (IgG)-based frequently encounter binding site barriers. Based the excellent tumor...
Glioblastoma is one of the malignant tumors central nervous system with high lethality, disability and low survival rate. Effective induction its death existing challenges. In recent studies, heat shock protein 27 (HSP27) has been shown to be associated ferroptosis; therefore, targeting HSP27 may a potential therapeutic approach for GBM.Immunohistochemistry western blot analysis were used detect expression in GBM tissues. CCK8, plate clone formation assay, EdU proliferation assay cell...
Abstract Few metrics exist to describe phenotypic diversity within ophthalmic imaging datasets, with researchers often using ethnicity as a surrogate marker for biological variability. We derived continuous, measured metric, the retinal pigment score (RPS), that quantifies degree of pigmentation from colour fundus photograph eye. RPS was validated two large epidemiological studies demographic and genetic data (UK Biobank EPIC-Norfolk Study) reproduced in Tanzanian, an Australian, Chinese...
Background: Glioblastoma is a common primary malignant intracranial tumor in adults associated with high disability and mortality. Despite the use of traditional surgical methods, postoperative radiotherapy, targeted therapies, median survival for glioma patients remains disappointingly brief. As result, there an urgent need to explore new targets develop novel drugs potentially improve patient survival. Notably, CLIC1 expression upregulated tumors correlated aggressiveness, metastasis, poor...
Purpose Cataract is a major cause of age-related eye diseases in the United States, and cataract extraction most commonly performed surgery on Medicare beneficiaries. Analyzing pattern delivery care at national level can highlight areas disparities. We evaluated geographic disparities seen to beneficiaries States. Setting extractions across States 2012. Design Cross-sectional study examining distance provider observed versus expected number extractions. Methods current procedural terminology...
Background: Cancer-associated fibroblasts (CAFs) are an essential cell population in the pancreatic cancer tumor microenvironment and extensively involved drug resistance immune evasion mechanisms. Long non-coding RNAs (lncRNAs) evolution regulate biological behavior mediated by CAFs. However, there is a lack of understanding prognostic signatures CAFs-associated lncRNAs patients. Methods: Transcriptomic clinical data for adenocarcinoma (PAAD) corresponding mutation were obtained from The...
Despite tremendous advances in cancer treatment and survival rates, pancreatic remains one of the most deadly afflictions fourth leading cause deaths world.Matrix Metalloproteinases (MMPs) are thought to be involved progression.Matrix metalloproteinase (MMP)-2 is known play a pivotal role tumor invasion, metastasis angiogenesis, validated anticancer target.Inhibition MMP-2 activity able reduce cell invasion suppress growth vivo.Two novel peptides, M204C4 M205C4, which could specially inhibit...
The English Diabetic Eye Screening Programme (DESP) offers people living with diabetes (PLD) annual screening. Less frequent screening has been advocated among PLD without diabetic retinopathy (DR), but evidence for each ethnic group is limited. We examined the potential effect of biennial versus on detection sight-threatening (STDR) and proliferative (PDR) DR from a large urban multi-ethnic DESP.PLD in North-East London DESP (January 2012 to December 2021) no two prior consecutive visits up...
Introduction The English Diabetic Eye Screening Programme (DESP) offers people living with diabetes (PLD) annual eye screening. We examined incidence and determinants of sight-threatening diabetic retinopathy (STDR) in a sociodemographically diverse multi-ethnic population. Research design methods North East London DESP cohort data (January 2012 to December 2021) 137 591 PLD no retinopathy, or non-STDR at baseline one/both eyes, were used calculate STDR rates by sociodemographic factors,...
Ectonucleotidase CD39 hydrolyzing extracellular ATP (eATP) functions as a key modulator of immune response in the tumor microenvironment, yet role contributing stem cells more immunosuppressive microenvironment remains elusive. Here we report that upregulation is crucial for decrease concentration around glioma (GSCs) to maintain an microenvironment. Adriamycin (ADM) able promote release ATP, which recruits dendritic (DCs) phagocytose GSCs. inhibition further increased concentrations...
To investigate the efficacy of Bushen Huoxue Fang (BSHXF, a traditional Chinese medicine formula) for improving recurrent spontaneous abortion (RSA) in mice and role tyrosine kinase (JAK2) transcriptional activator (STAT3) signaling pathway its therapeutic mechanism.Female CBA/J were caged with male DBA/2 to establish RSA mouse models, which randomly divided into model group, dydrogesterone group BSHXF female BALB/c as control (n=6). From first day pregnancy, subjected daily intragastric...
Data is the cornerstone of using AI models, because their performance directly depends on diversity, quantity, and quality data used for training. Using presents unique potential, particularly in medical applications that involve rich such as ophthalmology, encompassing a variety imaging methods, records, eye-tracking data. However, sharing comes with challenges regulatory issues privacy concerns. This review explores traditional nontraditional methods medicine, focusing previous works...
Stiffness- and relaxation-based diastolic function (DF) assessment can characterize the presence, severity, mechanism of dysfunction. Although frequency-based characterization arterial is routine (input impedance, characteristic wave reflection), DF via methods incorporating optimization/efficiency criteria lacking. By definition, optimal filling maximizes (E wave) volume minimizes “loss” at constant stored elastic strain energy (which initiates mechanical, recoil-driven filling). In...
Abstract Background Glioblastomas (GBMs) are grade IV central nervous system tumors characterized by a poor prognosis and short median overall survival. Effective induction of GBM cell death is difficult because the population genetically unstable, resistant to chemotherapy highly angiogenic. In recent studies, ubiquitin-specific protease 7 (USP7) shown scavenge ubiquitin from oncogenic protein substrates, so effective inhibition USP7 may be potential key treatment for GBM. Methods...
Glioma is a common type of brain tumor with high incidence and mortality rates. Procollagen C-protease enhancer protein (PCOLCE) has been shown to regulate growth metastasis in several cancers. However, the role PCOLCE glioma unknown. This study aims assess association between prognosis glioma, investigated potential mechanisms.The prognostic value was determined using data from nine publicly available cohorts. We also relationship immune microenvironment predicted response immunotherapy...
Background. As a clinically important natural isoquinoline alkaloid, berberine has been reported to possess various pharmacological effects.Objectives. This study was aimed investigate the effect of on cell migration and invasion in human retinoblastoma (Rb) cells.Material Methods. The cytotoxicity estimated by 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide (MTT) assay. After being stimulated with under concentrations, were evaluated transwell Then, expression levels...
A classifier is a software component, often based upon deep learning (DL), that categorizes each input provided to it into one of fixed set "classes". An IDK may additionally output an "I don't know" (IDK) on certain input. Given several different classifiers for the same operation, problem considered using them in concert such manner average duration successfully classify any minimized. Optimal algorithms are proposed solving this problem, both as and under additional constraint operation...