A5088743165- Ferroptosis and cancer prognosis
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer-related molecular mechanisms research
- Immune cells in cancer
- Cell Image Analysis Techniques
- Mitochondrial Function and Pathology
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Glioma Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Animal Nutrition and Physiology
- Single-cell and spatial transcriptomics
- Immune Response and Inflammation
- Alzheimer's disease research and treatments
- Musculoskeletal pain and rehabilitation
- Biosensors and Analytical Detection
- Cancer, Hypoxia, and Metabolism
- Anesthesia and Neurotoxicity Research
- Advanced biosensing and bioanalysis techniques
- RNA modifications and cancer
- Spine and Intervertebral Disc Pathology
- Sirtuins and Resveratrol in Medicine
- Neurological Disease Mechanisms and Treatments
- Angiogenesis and VEGF in Cancer
- Lipid metabolism and disorders
Beijing Sanbo Brain Hospital
2022-2025
Capital Medical University
2014-2025
Oklahoma State University
2024-2025
Xiangtan University
2023-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2025
Shanghai Zhabei District Shibei Hospital
2025
Third Hospital of Hebei Medical University
2022-2024
Hebei Medical University
2021-2024
Kunming University of Science and Technology
2024
Fujian Medical University
2023-2024
Abstract Dendritic and axonal morphology reflects the input output of neurons is a defining feature neuronal types 1,2 , yet our knowledge its diversity remains limited. Here, to systematically examine complete single-neuron morphologies on brain-wide scale, we established pipeline encompassing sparse labelling, whole-brain imaging, reconstruction, registration analysis. We fully reconstructed 1,741 from cortex, claustrum, thalamus, striatum other brain regions in mice. identified 11 major...
Carcinoembryonic antigen (CEA) is a recognized biomarker for lung cancer and can be used early detection. However, the clinical value of CEA not fully realized due to rigorous requirement high-sensitivity wide-range detection methods. Field-effect transistor (FET) biosensors, as one potentially powerful platforms, may detect with significantly higher sensitivity than conventional testing equipment, while their range are far below Here, we construct floating gate FET biosensor based on...
Background Metabolic dysfunction-associated fatty liver disease (MAFLD) has become the most common chronic disease. MAFLD is a major risk factor for end-stage including cirrhosis and primary cancer. The pathogenesis of complex not yet been clarified. To best our knowledge, few studies have conducted quantitative bibliometric analysis to evaluate published research. In this study, we comprehensive publications over past decade summarize current research hotspots predict future directions in...
Abstract Objectives Available literature documents that ischemic stroke can disrupt the morphology and function of mitochondria latter in other disease models be preserved by neuropilin-1 (NRP-1) via oxidative stress suppression. However, whether NRP-1 repair mitochondrial structure promote functional recovery after cerebral ischemia is still unknown. This study tackled this very issue explored underlying mechanism. Methods Adeno-associated viral (AAV)-NRP-1 was stereotaxically inoculated...
Abstract Background Necrotic enteritis (NE) is a major enteric disease in poultry, yet effective mitigation strategies remain elusive. Deoxycholic acid (DCA) and butyrate, two metabolites derived from the intestinal microbiota, have independently been shown to induce host defense peptide (HDP) synthesis. However, potential synergy between these compounds remains unexplored. Methods To investigate possible synergistic effect DCA butyrate regulating HDP synthesis barrier function, we treated...
Mitochondrial dysfunction contributes to cerebral ischemia-reperfusion (CI/R) injury, which can be ameliorated by Sirtuin-3 (SIRT3). Under stress conditions, the SIRT3-promoted mitochondrial functional recovery depends on both its activity and expression. However, approach enhance SIRT3 after CI/R injury remains unelucidated. In this study, Sprague-Dawley (SD) rats were intracranially injected with either adeno-associated viral Sirtuin-1 (AAV-SIRT1) or AAV-sh_SIRT1 before undergoing...
This letter generalizes the precoding-aided spatial modulation (PSM) to a multiuser (MU) downlink scenario. With precoding vectors elaborately designed, proposed MU-PSM scheme has capability resist multiple antenna eavesdropper. Specifically, signal matrices (SPMs) are designed cancel MU interference and modulate partial information bits on indices of receive antennas. To improve physical layer security, scrambling SPMs is conceived construct fast-varying matrix, which contributes...
ABSTRACT Ever since the seminal findings of Ramon y Cajal, dendritic and axonal morphology has been recognized as a defining feature neuronal types. Yet our knowledge concerning diversity morphologies, in particular distal projection patterns, is extremely limited. To systematically obtain single neuron full on brain-wide scale, we established platform with five major components: sparse labeling, whole-brain imaging, reconstruction, registration, classification. We achieved sparse, robust...
ABSTRACT Eimeria maxima is a major cause of coccidiosis in chickens and key predisposing factor for other economically significant diseases such as necrotic enteritis. However, detailed understanding the intestinal microbiome response to E. infection still lacking. This study aimed comprehensively investigate dynamic changes 14 days post-infection (dpi) with . Bacterial 16S rRNA gene sequencing was performed ileal cecal digesta collected from mock maxima- infected at prepatent (3 dpi), acute...
The intestinal microbiota is known to be altered by Eimeria-induced coccidiosis, but it remains unclear whether the fully restored after recovery. To address this, 110 newly hatched Cobb male broiler chickens were challenged with 2 × 104 sporulated oocysts of Eimeria maxima (EM) strain M6 or mock-infected saline on day 10. Body weight and feed intake recorded. Additionally, 10 mock- 12 EM-infected birds randomly selected assess small lesion, fecal oocyst shedding, ileal cecal compositions...
Sphingosine kinase 1 (SPHK1) is a member of the SPHK family, enzymes essential for phosphorylation sphingosine to sphingosine-1-phosphate (S1P). Previous studies have revealed important roles SPHK1 in inflammatory, anti-apoptotic, immune processes, and cancer. Although predictive significance possible gliomas recently been examined, precise molecular mechanisms remain unclear. We comprehensively examined investigated its correlation with glioma survival time using different datasets. The...
Breast desmoid-type fibromatosis (BDF) is a rare tumor predominated by mesenchymal cells. It has high recurrence rate, although distal metastasis uncommon. resembles breast cancer clinically, and histological pathology the only approach to confirmed diagnosis. Comprehensive individualized treatments were recommended for BDF patients. Here, we presented case of secondary primary carcinoma in our center. A 47-year-old female complained large mass her left 2.5 months. She past history with...
The urgent need for portable, sensitive, and accurate techniques to analyze multiple antibiotics is critical mitigating the health risks associated with low-dose coexposure-induced drug resistance, especially in infants. Emerging field-effect transistor (FET) biosensors are expected realize above requirement, but face challenges terms of sensitivity selectivity complex solutions practical applications. Here, we introduce a small-molecule coating strategy on carbon nanotube (CNT)-FET...
MicroRNAs (miRNAs), particularly miR-130a-5p, play pivotal roles in the tumorigenesis and progression of hepatocellular carcinoma (HCC) by participating diverse biological processes. The objective this study was to elucidate mechanistic basis which miR-130a-5p regulates expression tissue factor pathway inhibitor-2 (TFPI2) demonstrate subsequent impact miR-130a-5p/TFPI2 axis on HCC invasion. Expression levels TFPI2 were quantified HepG2 cell lines using quantitative real-time PCR (qRT-PCR)....
Calcium/calmodulin-dependent protein ID (CAMK1D) is widely expressed in many tissues and involved tumor cell growth. However, its role gliomas has not yet been elucidated. This study aimed to investigate the roles of CAMK1D proliferation, migration, invasion glioma. Through online datasets, Western blot, immunohistochemical analysis, glioma tissue significantly lower expression levels than normal brain (NB) tissues, was positively correlated with WHO classification. Kaplan-Meier survival...
Importance Pituitary adenoma is the second most common primary brain tumor. Perioperative hydrocortisone has been used for decades to avoid postoperative adrenal insufficiency. Recent studies suggest that withholding perioperative may be safe patients with an intact hypothalamus-pituitary-adrenal (HPA) axis. Objective To assess safety of during period pituitary surgery HPA Design, Setting, and Participants A parallel-group, triple-masked, noninferiority randomized clinical trial was...
Recently, localization has become an indispensable technique for wireless applications. In view of the limitation global position system (GPS) in certain environments, alternative approaches are demand. this paper, we consider a cooperative approach named sum-product algorithm over network (SPAWN). Although SPAWN theoretically facilitates localization, it several practical limitations. Specifically, results high computational complexity and increased traffic. The main lies selection...
Abstract Ever since the seminal findings of Ramon y Cajal, dendritic and axonal morphology has been recognized as a defining feature neuronal types. Yet our knowledge concerning diversity morphologies, in particular distal projection patterns, is extremely limited. To systematically obtain single neuron full on brain-wide scale, we established platform with five major components: sparse labeling, whole-brain imaging, reconstruction, registration, classification. We achieved sparse, robust...