Lydia Ng

ORCID: 0000-0002-7499-3514
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About
Contact & Profiles
Research Areas
  • Single-cell and spatial transcriptomics
  • Cell Image Analysis Techniques
  • Neural dynamics and brain function
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Gene expression and cancer classification
  • Neuroscience and Neuropharmacology Research
  • Bioinformatics and Genomic Networks
  • Medical Image Segmentation Techniques
  • Functional Brain Connectivity Studies
  • Congenital heart defects research
  • Mitochondrial Function and Pathology
  • Advanced Fluorescence Microscopy Techniques
  • Advanced Neuroimaging Techniques and Applications
  • Photoreceptor and optogenetics research
  • Gene Regulatory Network Analysis
  • Radiomics and Machine Learning in Medical Imaging
  • Visual perception and processing mechanisms
  • Memory and Neural Mechanisms
  • Scientific Computing and Data Management
  • Neurogenesis and neuroplasticity mechanisms
  • Health, Environment, Cognitive Aging
  • Medical Imaging Techniques and Applications
  • Birth, Development, and Health
  • Neurobiology and Insect Physiology Research
  • Neuroscience and Neural Engineering

Allen Institute
2016-2025

Allen Institute for Brain Science
2016-2025

Bridge University
2023

University of Washington
2007-2018

Cleveland Clinic
2018

Pathwest Laboratory Medicine
2009

Strategic Insight (United States)
2003

Ed S. Lein Michael Hawrylycz Nancy Ao Mikael Ayres Amy Bensinger and 95 more Amy Bernard Andrew F. Boe Mark S. Boguski Kevin S. Brockway Emi J. Byrnes Lin Chen Li Chen Tsuey-Ming Chen Mei Chi Chin Jimmy Chong Brian E. Crook Aneta Czaplinska Chinh Dang Suvro Datta Nick Dee Aimee L. Desaki Tsega Desta Ellen Diep Tim Dolbeare Matthew J. Donelan Hong‐Wei Dong Jennifer Dougherty Ben J. Duncan Amanda Ebbert Gregor Eichele Lili K. Estin Casey Faber Benjamin A.C. Facer R.Theodore Fields Shanna R. Fischer Tim Fliss Cliff Frensley Sabrina N. Gates Katie Glattfelder Kevin R. Halverson Matthew R. Hart John G. Hohmann Maureen P. Howell Darren P. Jeung Rebecca A. Johnson Paul A. Karr Reena Kawal Jolene Kidney Rachel H. Knapik Chihchau L. Kuan James H. Lake Annabel R. Laramee Kirk Larsen Christopher Lau Tracy Lemon Agnes JH Liang Ying Liu Lon T. Luong Jesse Michaels Judith J. Morgan Rebecca J. Morgan Marty Mortrud Nerick F. Mosqueda Lydia Ng Randy Ng Geralyn J. Orta Caroline C. Overly Tu H. Pak Sheana Parry Dev S. Pathak Owen C. Pearson Ralph B. Puchalski Zackery L. Riley Hannah R. Rockett Stephen A. Rowland Joshua J. Royall Marcos J. Ruiz Nadia R. Sarno Katherine Schaffnit Nadiya V. Shapovalova Taz Sivisay Clifford R. Slaughterbeck Simón C. Smith Kimberly A. Smith Bryan I. Smith Andy J. Sodt Nick N. Stewart Kenda-Ruth Stumpf Susan M. Sunkin Madhavi Sutram Angelene Tam Carey D. Teemer Christina Thaller Carol L. Thompson Lee R. Varnam Axel Visel Ray M. Whitlock Paul Wohnoutka Crissa K. Wolkey Victoria Wong

10.1038/nature05453 article EN Nature 2006-12-06

The Allen Brain Atlas (http://www.brain-map.org) provides a unique online public resource integrating extensive gene expression data, connectivity data and neuroanatomical information with powerful search viewing tools for the adult developing brain in mouse, human non-human primate. Here, we review resources available at Atlas, describing each product type [such as situ hybridization (ISH) supporting histology, microarray, RNA sequencing, reference atlases, projection mapping magnetic...

10.1093/nar/gks1042 article EN cc-by-nc Nucleic Acids Research 2012-11-27

Glioblastoma is an aggressive brain tumor that carries a poor prognosis. The tumor's molecular and cellular landscapes are complex, their relationships to histologic features routinely used for diagnosis unclear. We present the Ivy Atlas, anatomically based transcriptional atlas of human glioblastoma aligns individual with genomic alterations gene expression patterns, thus assigning information most important morphologic hallmarks tumor. its clinical database freely accessible online data...

10.1126/science.aaf2666 article EN Science 2018-05-10

Significant advances in circuit-level analyses of the brain require tools that allow for labeling, modulation gene expression, and monitoring manipulation cellular activity specific cell types and/or anatomical regions. Large-scale projects individual laboratories have produced hundreds gene-specific promoter-driven Cre mouse lines invaluable enabling genetic access to subpopulations cells brain. However, potential utility each line may not be fully realized without systematic whole...

10.3389/fncir.2014.00076 article EN cc-by Frontiers in Neural Circuits 2014-07-10
Edward M. Callaway Hong‐Wei Dong Joseph R. Ecker Michael Hawrylycz Z. Josh Huang and 95 more Ed S. Lein John Ngai Pavel Osten Bing Ren Andreas S. Tolias Owen White Hongkui Zeng Xiaowei Zhuang Giorgio A. Ascoli M. Margarita Behrens Jerold Chun Guoping Feng James C. Gee Satrajit Ghosh Yaroslav O. Halchenko Ronna Hertzano Byung Kook Lim Maryann E. Martone Lydia Ng Lior Pachter Alexander J. Ropelewski Timothy L. Tickle X. William Yang Kun Zhang Trygve E. Bakken Philipp Berens Tanya L. Daigle Julie A. Harris Nikolas L. Jorstad Brian Kalmbach Dmitry Kobak Yang Eric Li Hanqing Liu Katherine S. Matho Eran A. Mukamel Maitham Naeemi Federico Scala Pengcheng Tan Jonathan T. Ting Fangming Xie Meng Zhang Zhuzhu Zhang Jingtian Zhou Brian Zingg Ethan J. Armand Zizhen Yao Darren Bertagnolli Tamara Casper Kirsten Crichton Nick Dee Dinh Diep Song‐Lin Ding Weixiu Dong Elizabeth L. Dougherty Olivia Fong Melissa Goldman Jeff Goldy Rebecca D. Hodge Lijuan Hu C. Dirk Keene Fenna M. Krienen Matthew Kroll Blue B. Lake Kanan Lathia Sten Linnarsson Christine S. Liu Evan Z. Macosko Steven A. McCarroll Delissa McMillen Naeem Nadaf Thuc Nghi Nguyen Carter R. Palmer Thanh Pham Nongluk Plongthongkum Nora Reed Aviv Regev Christine Rimorin William J. Romanow Stephen Savoia Kimberly Siletti Kimberly A. Smith Josef Šulc Bosiljka Tasic Michael Tieu Amy Torkelson Herman Tung Cindy T. J. van Velthoven Charles Vanderburg Anna Marie Yanny Rongxin Fang Xiaomeng Hou Jacinta Lucero Julia Osteen António Pinto‐Duarte Olivier Poirion

Here we report the generation of a multimodal cell census and atlas mammalian primary motor cortex as initial product BRAIN Initiative Cell Census Network (BICCN). This was achieved by coordinated large-scale analyses single-cell transcriptomes, chromatin accessibility, DNA methylomes, spatially resolved morphological electrophysiological properties cellular resolution input-output mapping, integrated through cross-modal computational analysis. Our results advance collective knowledge...

10.1038/s41586-021-03950-0 article EN cc-by Nature 2021-10-06

10.1016/j.cell.2020.09.057 article EN publisher-specific-oa Cell 2020-11-01

10.1038/s41593-019-0417-0 article EN Nature Neuroscience 2019-06-17

The mammalian brain consists of millions to billions cells that are organized into many cell types with specific spatial distribution patterns and structural functional properties1-3. Here we report a comprehensive high-resolution transcriptomic cell-type atlas for the whole adult mouse brain. was created by combining single-cell RNA-sequencing (scRNA-seq) dataset around 7 million profiled (approximately 4.0 passing quality control), approximately 4.3 using multiplexed error-robust...

10.1038/s41586-023-06812-z article EN cc-by Nature 2023-12-13

10.1038/nature18637 article EN Nature 2016-07-01

ABSTRACT Detailed anatomical understanding of the human brain is essential for unraveling its functional architecture, yet current reference atlases have major limitations such as lack whole‐brain coverage, relatively low image resolution, and sparse structural annotation. We present first digital atlas to incorporate neuroimaging, high‐resolution histology, chemoarchitecture across a complete adult female brain, consisting magnetic resonance imaging (MRI), diffusion‐weighted (DWI), 1,356...

10.1002/cne.24080 article EN cc-by-nc-nd The Journal of Comparative Neurology 2016-07-15

Understanding how brain activation mediates behaviors is a central goal of systems neuroscience. Here, we apply an automated method for mapping in the mouse order to probe sex-specific social are represented male brain. Our uses immediate-early-gene c-fos, marker neuronal activation, visualized by serial two-photon tomography: c-fos-GFP+ neurons computationally detected, their distribution registered reference and atlas, numbers analyzed statistical tests. results reveal distinct shared...

10.1016/j.celrep.2014.12.014 article EN cc-by Cell Reports 2014-12-31

Abstract Dendritic and axonal morphology reflects the input output of neurons is a defining feature neuronal types 1,2 , yet our knowledge its diversity remains limited. Here, to systematically examine complete single-neuron morphologies on brain-wide scale, we established pipeline encompassing sparse labelling, whole-brain imaging, reconstruction, registration analysis. We fully reconstructed 1,741 from cortex, claustrum, thalamus, striatum other brain regions in mice. identified 11 major...

10.1038/s41586-021-03941-1 article EN cc-by Nature 2021-10-06
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