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Tsega Desta

ORCID: 0000-0003-4477-3446
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A5102977444
Research Areas
  • Single-cell and spatial transcriptomics
  • Cell Image Analysis Techniques
  • Gene expression and cancer classification
  • Neural dynamics and brain function
  • Neuroscience and Neuropharmacology Research
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Mitochondrial Function and Pathology
  • Genetic Mapping and Diversity in Plants and Animals
  • Genetics and Neurodevelopmental Disorders
  • Congenital heart defects research
  • Epigenetics and DNA Methylation
  • Advanced Fluorescence Microscopy Techniques

Allen Institute for Brain Science
 2006-2022

Allen Institute
 2006-2022

 Genome-wide atlas of gene expression in the adult mouse brain
OPENALEX - Publications 
Ed S. Lein Michael Hawrylycz Nancy Ao Mikael Ayres Amy Bensinger and 95 more Amy Bernard Andrew F. Boe Mark S. Boguski Kevin S. Brockway Emi J. Byrnes Lin Chen Li Chen Tsuey-Ming Chen Mei Chi Chin Jimmy Chong Brian E. Crook Aneta Czaplinska Chinh Dang Suvro Datta Nick Dee Aimee L. Desaki Tsega Desta Ellen Diep Tim Dolbeare Matthew J. Donelan Hong‐Wei Dong Jennifer Dougherty Ben J. Duncan Amanda Ebbert Gregor Eichele Lili K. Estin Casey Faber Benjamin A.C. Facer R.Theodore Fields Shanna R. Fischer Tim Fliss Cliff Frensley Sabrina N. Gates Katie Glattfelder Kevin R. Halverson Matthew R. Hart John G. Hohmann Maureen P. Howell Darren P. Jeung Rebecca A. Johnson Paul A. Karr Reena Kawal Jolene Kidney Rachel H. Knapik Chihchau L. Kuan James H. Lake Annabel R. Laramee Kirk Larsen Christopher Lau Tracy Lemon Agnes JH Liang Ying Liu Lon T. Luong Jesse Michaels Judith J. Morgan Rebecca J. Morgan Marty Mortrud Nerick F. Mosqueda Lydia Ng Randy Ng Geralyn J. Orta Caroline C. Overly Tu H. Pak Sheana Parry Dev S. Pathak Owen C. Pearson Ralph B. Puchalski Zackery L. Riley Hannah R. Rockett Stephen A. Rowland Joshua J. Royall Marcos J. Ruiz Nadia R. Sarno Katherine Schaffnit Nadiya V. Shapovalova Taz Sivisay Clifford R. Slaughterbeck Simón C. Smith Kimberly A. Smith Bryan I. Smith Andy J. Sodt Nick N. Stewart Kenda-Ruth Stumpf Susan M. Sunkin Madhavi Sutram Angelene Tam Carey D. Teemer Christina Thaller Carol L. Thompson Lee R. Varnam Axel Visel Ray M. Whitlock Paul Wohnoutka Crissa K. Wolkey Victoria Wong

10.1038/nature05453 article EN Nature 2006-12-06
 Integrated Morphoelectric and Transcriptomic Classification of Cortical GABAergic Cells
OPENALEX - Publications 
Nathan W. Gouwens Staci A. Sorensen Fahimeh Baftizadeh Agata Budzillo Brian Lee and 93 more Tim Jarsky Lauren Alfiler Katherine Baker Eliza Barkan Kyla Berry Darren Bertagnolli Kris Bickley Jasmine Bomben Thomas Braun Krissy Brouner Tamara Casper Kirsten Crichton Tanya L. Daigle Rachel Dalley Rebecca de Frates Nick Dee Tsega Desta Samuel Dingman Lee Nadezhda Dotson Tom Egdorf Lauren Ellingwood Rachel Enstrom Luke Esposito Colin Farrell David Feng Olivia Fong Rohan Gala Clare Gamlin Amanda Gary Alexandra Glandon Jeff Goldy Melissa Gorham Lucas T. Graybuck Hong Gu Kristen Hadley Michael Hawrylycz Alex M. Henry DiJon Hill Madie Hupp Sara Kebede Tae Kyung Kim Lisa Kim Matthew Kroll Changkyu Lee Katherine E. Link Matthew Mallory Rusty Mann Michelle Maxwell Mary McGraw Delissa McMillen Alice Mukora Lindsay Ng Lydia Ng Kiet Ngo Philip R. Nicovich Aaron Oldre Daniel Park Hanchuan Peng Osnat Penn Thanh Pham Christina Alice Pom Zoran Popović Lydia Potekhina Ramkumar Rajanbabu Shea Ransford David Reid Christine Rimorin Miranda Robertson Kara Ronellenfitch Augustin Ruiz David Sandman Kimberly A. Smith Josef Šulc Susan M. Sunkin Aaron Szafer Michael Tieu Amy Torkelson Jessica Trinh Herman Tung Wayne Wakeman Katelyn Ward Grace Williams Zhi Zhou Jonathan T. Ting Anton Arkhipov Uygar Sümbül Ed S. Lein Christof Koch Zizhen Yao Bosiljka Tasic Jim Berg Gabe J. Murphy Hongkui Zeng

10.1016/j.cell.2020.09.057 article EN publisher-specific-oa Cell 2020-11-01
 Classification of electrophysiological and morphological neuron types in the mouse visual cortex
OPENALEX - Publications 
Nathan W. Gouwens Staci A. Sorensen Jim Berg Changkyu Lee Tim Jarsky and 90 more Jonathan T. Ting Susan M. Sunkin David Feng Costas A. Anastassiou Eliza Barkan Kris Bickley Nicole Blesie Thomas Braun Krissy Brouner Agata Budzillo Shiella Caldejon Tamara Casper Dan Castelli Peter Chong Kirsten Crichton Christine Cuhaciyan Tanya L. Daigle Rachel Dalley Nick Dee Tsega Desta Song‐Lin Ding Samuel Dingman Alyse Doperalski Nadezhda Dotson Tom Egdorf Michael Fisher Rebecca de Frates Emma Garren Marissa Garwood Amanda Gary Nathalie Gaudreault Keith B. Godfrey Melissa Gorham Hong Gu Caroline Habel Kristen Hadley James Harrington Julie A. Harris Alex M. Henry DiJon Hill Sam Josephsen Sara Kebede Lisa Kim Matthew Kroll Brian Lee Tracy Lemon Katherine E. Link Xiaoxiao Liu Brian Long Rusty Mann Mary McGraw Ştefan Mihalaş Alice Mukora Gabe J. Murphy Lindsay Ng Kiet Ngo Thuc Nghi Nguyen Philip R. Nicovich Aaron Oldre Daniel Park Sheana Parry Jed Perkins Lydia Potekhina David Reid Miranda Robertson David Sandman Martin Schroedter Cliff Slaughterbeck Gilberto Soler‐Llavina Josef Šulc Aaron Szafer Bosiljka Tasic Naz Taskin Corinne Teeter Nivretta Thatra Herman Tung Wayne Wakeman Grace Williams Rob Young Zhi Zhou Colin Farrell Hanchuan Peng Michael Hawrylycz Ed S. Lein Lydia Ng Anton Arkhipov Amy Bernard John W. Phillips Hongkui Zeng Christof Koch

10.1038/s41593-019-0417-0 article EN Nature Neuroscience 2019-06-17
 A comprehensive transcriptional map of primate brain development
OPENALEX - Publications 
Trygve E. Bakken Jeremy A. Miller Song‐Lin Ding Susan M. Sunkin Kimberly A. Smith and 94 more Lydia Ng Aaron Szafer Rachel Dalley Joshua J. Royall Tracy Lemon Sheila Shapouri Kaylynn Aiona James M. Arnold Jeffrey Bennett Darren Bertagnolli Kristopher Bickley Andrew F. Boe Krissy Brouner Stephanie Butler Emi J. Byrnes Shiella Caldejon Anita Carey Shelby Cate Mike Chapin Jefferey Chen Nick Dee Tsega Desta Tim Dolbeare Nadia Dotson Amanda Ebbert Erich Fulfs Garrett Gee Terri L. Gilbert Jeff Goldy Lindsey Gourley Ben W. Gregor Guangyu Gu Jon G. Hall Zeb Haradon David R. Haynor Nika Hejazinia Anna Hoerder‐Suabedissen Robert Howard Jay Jochim Marty Kinnunen Ali Kriedberg Chihchau L. Kuan Christopher Lau Chang‐Kyu Lee Felix Lee Lon T. Luong Naveed Mastan Ryan May J.L Melchor Nerick F. Mosqueda Erika Mott Kiet Ngo Julie Nyhus Aaron Oldre Eric N. Olson Jody Parente Patrick D. Parker Sheana Parry Julie Pendergraft Lydia Potekhina Melissa Reding Zackery L. Riley T. Guy Roberts Brandon M. A. Rogers Kate Roll David W. Rosen David Sandman Melaine Sarreal Nadiya V. Shapovalova Shi Shu Nathan Sjoquist Andy J. Sodt Robbie Townsend Lissette S. Velasquez Udi Wagley Wayne Wakeman Cassandra White Crissa Bennett Jennifer E. Wu Rob Young Brian L. Youngstrom Paul Wohnoutka Richard A. Gibbs Jeffrey Rogers John G. Hohmann Michael Hawrylycz Robert F. Hevner Zoltán Molnár John W. Phillips Chinh Dang Allan R. Jones David G. Amaral Amy Bernard Ed S. Lein

10.1038/nature18637 article EN Nature 2016-07-01
 Human neocortical expansion involves glutamatergic neuron diversification
OPENALEX - Publications 
Jim Berg Staci A. Sorensen Jonathan T. Ting Jeremy A. Miller Thomas Chartrand and 95 more Anatoly Buchin Trygve E. Bakken Agata Budzillo Nick Dee Song‐Lin Ding Nathan W. Gouwens Rebecca D. Hodge Brian Kalmbach Changkyu Lee Brian Lee Lauren Alfiler Katherine Baker Eliza Barkan Allison Beller Kyla Berry Darren Bertagnolli Kris Bickley Jasmine Bomben Thomas Braun Krissy Brouner Tamara Casper Peter Chong Kirsten Crichton Rachel Dalley Rebecca de Frates Tsega Desta Samuel Dingman Lee Florence D. D’Orazi Nadezhda Dotson Tom Egdorf Rachel Enstrom Colin Farrell David Feng Olivia Fong Szabina Furdan Anna A. Galakhova Clare Gamlin Amanda Gary Alexandra Glandon Jeff Goldy Melissa Gorham Natalia A. Goriounova Sergey L. Gratiy Lucas T. Graybuck Hong Gu Kristen Hadley Nathan Hansen Tim S. Heistek Alex M. Henry Djai B. Heyer DiJon Hill Chris Hill Madie Hupp Tim Jarsky Sara Kebede Lisa Keene Lisa Kim Mean‐Hwan Kim Matthew Kroll Caitlin S. Latimer Boaz P. Levi Katherine E. Link Matthew Mallory Rusty Mann Desiree A. Marshall Michelle Maxwell Mary McGraw Delissa McMillen Erica J. Melief Eline J. Mertens Leona Mezei Norbert Mihut Stephanie Mok Gábor Molnár Alice Mukora Lindsay Ng Kiet Ngo Philip R. Nicovich Julie Nyhus Gáspár Oláh Aaron Oldre Victoria Omstead Attila Ozsvár Daniel Park Hanchuan Peng Trangthanh Pham Christina Alice Pom Lydia Potekhina Ramkumar Rajanbabu Shea Ransford David Reid Christine Rimorin Augustin Ruiz David Sandman Josef Šulc

Abstract The neocortex is disproportionately expanded in human compared with mouse 1,2 , both its total volume relative to subcortical structures and the proportion occupied by supragranular layers composed of neurons that selectively make connections within other telencephalic structures. Single-cell transcriptomic analyses show an increased diversity glutamatergic neuron types pronounced gradients as a function cortical depth 3 . Here, probe functional anatomical correlates this diversity,...

10.1038/s41586-021-03813-8 article EN cc-by Nature 2021-10-06
 Toward an integrated classification of neuronal cell types: morphoelectric and transcriptomic characterization of individual GABAergic cortical neurons
OPENALEX - Publications 
Nathan W. Gouwens Staci A. Sorensen Fahimeh Baftizadeh Agata Budzillo Brian Lee and 92 more Tim Jarsky Lauren Alfiler Anton Arkhipov Katherine Baker Eliza Barkan Kyla Berry Darren Bertagnolli Kris Bickley Jasmine Bomben Thomas Braun Krissy Brouner Tamara Casper Kirsten Crichton Tanya L. Daigle Rachel Dalley Rebecca de Frates Nick Dee Tsega Desta Samuel Dingman Lee Nadezhda Dotson Tom Egdorf Lauren Ellingwood Rachel Enstrom Luke Esposito Colin Farrell David Feng Olivia Fong Rohan Gala Clare Gamlin Amanda Gary Alexandra Glandon Jeff Goldy Melissa Gorham Lucas T. Graybuck Hong Gu Kristen Hadley Michael Hawrylycz Alex M. Henry DiJon Hill Madie Hupp Sara Kebede Tae Kyung Kim Lisa Kim Matthew Kroll Changkyu Lee Katherine E. Link Matthew Mallory Rusty Mann Michelle Maxwell Mary McGraw Delissa McMillen Alice Mukora Lindsay Ng Lydia Ng Kiet Ngo Philip R. Nicovich Aaron Oldre Daniel Park Hanchuan Peng Osnat Penn Thanh Pham Christina Alice Pom Lydia Potekhina Ramkumar Rajanbabu Shea Ransford David Reid Christine Rimorin Miranda Robertson Kara Ronellenfitch Augustin Ruiz David Sandman Kimberly A. Smith Josef Šulc Susan M. Sunkin Aaron Szafer Michael Tieu Amy Torkelson Jessica Trinh Herman Tung Wayne Wakeman Katelyn Ward Grace Williams Zhi Zhou Jonathan T. Ting Uygar Sümbül Ed S. Lein Christof Koch Zizhen Yao Bosiljka Tasic Jim Berg Gabe J. Murphy Hongkui Zeng

Abstract Neurons are frequently classified into distinct groups or cell types on the basis of structural, physiological, genetic attributes. To better constrain definition neuronal types, we characterized transcriptomes and intrinsic physiological properties over 3,700 GABAergic mouse visual cortical neurons reconstructed local morphologies 350 those neurons. We found that most transcriptomic (t-types) occupy specific laminar positions within cortex, many t-types exhibit consistent...

10.1101/2020.02.03.932244 preprint EN cc-by-nd bioRxiv (Cold Spring Harbor Laboratory) 2020-02-04
 Human cortical expansion involves diversification and specialization of supragranular intratelencephalic-projecting neurons
OPENALEX - Publications 
Jim Berg Staci A. Sorensen Jonathan T. Ting Jeremy A. Miller Thomas Chartrand and 95 more Anatoly Buchin Trygve E. Bakken Agata Budzillo Nick Dee Song‐Lin Ding Nathan W. Gouwens Rebecca D. Hodge Brian Kalmbach Changkyu Lee Brian Lee Lauren Alfiler Katherine Baker Eliza Barkan Allison Beller Kyla Berry Darren Bertagnolli Kris Bickley Jasmine Bomben Thomas Braun Krissy Brouner Tamara Casper Peter Chong Kirsten Crichton Rachel Dalley Rebecca de Frates Tsega Desta Samuel Dingman Lee Florence D. D’Orazi Nadezhda Dotson Tom Egdorf Rachel Enstrom Colin Farrell David Feng Olivia Fong Szabina Furdan Anna A. Galakhova Clare Gamlin Amanda Gary Alexandra Glandon Jeff Goldy Melissa Gorham Natalia A. Goriounova Sergey L. Gratiy Lucas T. Graybuck Hong Gu Kristen Hadley Nathan Hansen Tim S. Heistek Alex M. Henry Djai B. Heyer DiJon Hill Chris Hill Madie Hupp Tim Jarsky Sara Kebede Lisa Keene Lisa Kim Mean-Hwan Kim Matthew Kroll Caitlin S. Latimer Boaz P. Levi Katherine E. Link Matthew Mallory Rusty Mann Desiree A. Marshall Michelle Maxwell Mary McGraw Delissa McMillen Erica J. Melief Eline J. Mertens Leona Mezei Norbert Mihut Stephanie Mok Gábor Molnár Alice Mukora Lindsay Ng Kiet Ngo Philip R. Nicovich Julie Nyhus Gáspár Oláh Aaron Oldre Victoria Omstead Attila Ozsvár Daniel Park Hanchuan Peng Trangthanh Pham Christina Alice Pom Lydia Potekhina Ramkumar Rajanbabu Shea Ransford David Reid Christine Rimorin Augustin Ruiz David Sandman Josef Šulc

The neocortex is disproportionately expanded in human compared to mouse, both its total volume relative subcortical structures and the proportion occupied by supragranular layers that selectively make connections within cortex other telencephalic structures. Single-cell transcriptomic analyses of mouse show an increased diversity glutamatergic neuron types pronounced gradients as a function cortical depth. To probe functional anatomical correlates this diversity, we describe robust Patch-seq...

10.1101/2020.03.31.018820 preprint EN cc-by-nd bioRxiv (Cold Spring Harbor Laboratory) 2020-04-02
 Divergent and nonuniform gene expression patterns in mouse brain
OPENALEX - Publications 
John A. Morris Joshua J. Royall Darren Bertagnolli Andrew F. Boe Josh Burnell and 24 more Emi J. Byrnes Cathy Copeland Tsega Desta Shanna R. Fischer Jeff Goldy Katie Glattfelder Jolene Kidney Tracy Lemon Geralyn J. Orta Sheana Parry Dev S. Pathak Owen C. Pearson Melissa Reding Sheila Shapouri Kimberly A. Smith Chad Soden Beth Solan John R. Weller Joseph S. Takahashi Caroline C. Overly Ed S. Lein Michael Hawrylycz John G. Hohmann Allan R. Jones

Considerable progress has been made in understanding variations gene sequence and expression level associated with phenotype, yet how genetic diversity translates into complex phenotypic differences remains poorly understood. Here, we examine the relationship between background spatial patterns of across seven strains mice, providing most extensive cellular-resolution comparative analysis mammalian brain to date. Using comprehensive brainwide anatomic coverage (more than 200 regions),...

10.1073/pnas.1003732107 article EN Proceedings of the National Academy of Sciences 2010-10-18
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