Sarah A. Naylor
A5060607874- Neural dynamics and brain function
- Neurobiology and Insect Physiology Research
- Neuroscience and Neuropharmacology Research
- Photoreceptor and optogenetics research
- Retinal Development and Disorders
- Axon Guidance and Neuronal Signaling
- Zebrafish Biomedical Research Applications
- Signaling Pathways in Disease
- Visual perception and processing mechanisms
- Autophagy in Disease and Therapy
- Ubiquitin and proteasome pathways
- Cellular transport and secretion
- Endoplasmic Reticulum Stress and Disease
- Lysosomal Storage Disorders Research
- Microtubule and mitosis dynamics
Allen Institute
2019-2023
Allen Institute for Brain Science
2019-2021
Washington University in St. Louis
2011-2012
The detection of novel stimuli is critical to learn and survive in a dynamic environment. Though powerfully affect brain activity, their impact on specific cell types circuits not well understood. Disinhibition one candidate mechanism for novelty-induced enhancements activity. Here we characterize the stimulus novelty disinhibitory circuit components using longitudinal 2-photon calcium imaging Vip, Sst, excitatory populations mouse visual cortex. Mice behavioral task with that become highly...
Abstract The mammalian visual system, from retina to neocortex, has been extensively studied at both anatomical and functional levels. Anatomy indicates the cortico-thalamic system is hierarchical, but characterization of cellular-level interactions across multiple levels this hierarchy lacking, partially due challenge simultaneously recording activity numerous regions. Here, we describe a large, open dataset (part Allen Brain Observatory ) that surveys spiking units in six cortical two...
Axonal degeneration is a molecular self-destruction cascade initiated following traumatic, toxic, and metabolic insults. Its mechanism underlies number of disorders including hereditary diabetic neuropathies the neurotoxic side effects chemotherapy drugs. Molecules that promote axonal could represent potential targets for therapy. To identify such molecules, we designed screening platform based on intoxication Drosophila larvae with paclitaxel (taxol), chemotherapeutic agent causes...
Autophagy is a self-degradative process in which cellular material enclosed within autophagosomes and trafficked to lysosomes for degradation. Autophagosomal biogenesis well described; however mechanisms controlling the growth ultimate size of are unclear. Here we demonstrate that Drosophila membrane protein Ema required autophagosomes. In an ema mutant, form response starvation developmental cues, these can mature into autolysosomes; very small, autophagy impaired. fat body cells, localizes...
Abstract Synaptic target selection is critical for establishing functional neuronal circuits. The mechanisms regulating remain incompletely understood. We describe a role the EGF receptor and its ligand Gurken in of octopaminergic Type II neurons Drosophila neuromuscular system. Mutants happyhour , regulator EGFR signaling, form ectopic junctions. These innervations are due to inappropriate selection. demonstrate that signaling necessary sufficient inhibit synaptic by these neurons,...