A5054613167- Neuroinflammation and Neurodegeneration Mechanisms
- Synthesis and Characterization of Heterocyclic Compounds
- Sperm and Testicular Function
- Neurological Disease Mechanisms and Treatments
- Chemical synthesis and alkaloids
- Immune cells in cancer
- Synthesis and Biological Activity
- Menstrual Health and Disorders
- Marine Sponges and Natural Products
- Heme Oxygenase-1 and Carbon Monoxide
- Chemotherapy-induced cardiotoxicity and mitigation
- Reproductive Biology and Fertility
- Synthesis and pharmacology of benzodiazepine derivatives
- Metal-Organic Frameworks: Synthesis and Applications
- Synthesis and biological activity
- Axial and Atropisomeric Chirality Synthesis
- Endometriosis Research and Treatment
- Neuroscience of respiration and sleep
- Advanced Glycation End Products research
- Chemical Reaction Mechanisms
- Cytokine Signaling Pathways and Interactions
- Eicosanoids and Hypertension Pharmacology
- Cancer, Lipids, and Metabolism
- Cell death mechanisms and regulation
- Phytoestrogen effects and research
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Tianjin University of Traditional Chinese Medicine
2024
First Affiliated Hospital of Henan University
2019-2023
Xiamen University
1998-2001
Doxorubicin (DOX) is a highly effective chemotherapeutic that for various tumours. However, the clinical application of DOX has been limited by adverse reactions such as cardiotoxicity and heart failure. Since DOX-induced irreversible, drugs to prevent are needed.This study aimed investigate effect total flavonoids Selaginella tamariscina (P.Beauv.) Spring (TFST) on doxorubicin-induced cardiotoxicity.The present established models in C57BL/6 mice treated with (cumulative dose: 20 mg/kg body...
To investigate the efficacy of Bushen Huoxue Fang (BSHXF, a traditional Chinese medicine formula) for improving recurrent spontaneous abortion (RSA) in mice and role tyrosine kinase (JAK2) transcriptional activator (STAT3) signaling pathway its therapeutic mechanism.Female CBA/J were caged with male DBA/2 to establish RSA mouse models, which randomly divided into model group, dydrogesterone group BSHXF female BALB/c as control (n=6). From first day pregnancy, subjected daily intragastric...
We investigated the protective effects of ephedra herb (HEPH) on adriamycin-induced testicular toxicity in rats and explored potential mechanisms underlying these effects.A rat model adriamycin injury was established, sperm motility-related indicator oxidative stress levels testis were evaluated. Serum sex hormones cell apoptosis detected by enzyme-linked immunosorbent assay flow cytometry, respectively. Western blotting (WB), immunofluorescence analyses, reverse transcription-polymerase...
The present study investigated the effect of active components Descurainia sophia on allergic asthma and explored underlying mechanism. SD male rats were randomly divided into a normal group(NC), model group(M), D. decoction group(DS), fatty oil group(FO), flavonoid glycoside group(FG), oligosaccharide group(Oli), positive drug dexamethasone group(Y). was induced in by intraperitoneal injection ovalbumin(OVA) aluminum hydroxide gel adjuvant(sensitization) atomization OVA...
Abstract A concise and versatile approach to the activated form of (3S, 4R)-statine 6 its analogues is described. The key steps involve reductive alkylation (S)-O-tert-butyldimethysilylmalimide 12.
Pseudoephedrine (PSE) has rapid absorption and metabolism, which limits its pharmacologic actions. We postulated that pseudoephedrine nanoparticles (PSE-NPs) with high bioavailability could overcome this limitation. The defensive function of PSE-NPs against adriamycin-induced reproductive toxicity in mice was studied.We encapsulated PSE polylactide-polyglycolide (PLGA-NPs) verified their protective activity testicular injury vivo vitro.We report a promising delivery system loads into...
Lipid deposition in the kidney can cause serious damage to kidney, and there is an obvious epithelial-mesenchymal transition (EMT) fibrosis late stage. To investigate interventional effects mechanisms of phenolic compounds from Mori Cortex on EMT induced by sodium oleate-induced lipid renal tubular epithelial cells (NRK-52e cells), role played CD36 adjustment process, NRK-52e 200 μmol/L oleate were given 10 μmoL/L moracin-P-2″-O-β-d-glucopyranoside (Y-1), moracin-P-3'-O-β-d-glucopyranoside...
Abstract C 34 H CdN 12 O 2 S , triclinic, P 1̄, a = 9.6872(6) Å, b 10.4523(7) c 10.8422(9) α 113.022(7)°, β 96.919(6)°, γ 104.526(6)°, Z 1, V 948.20(13) Å 3 R gt ( F ) 0.0564, wR ref 0.1511, T 293(2) K.
Purpose: Fatty oil of Descurainia Sophia (OIL) has poor stability and low solubility, which limits its pharmacological effects. We hypothesized that fatty nanoparticles (OIL-NPs) could overcome this limitation. The protective effect OIL-NPs against monocrotaline-induced lung injury in rats was studied. Methods: prepared by wrapping with polylactic-polyglycolide (PLGA-NPs) conducted vivo vitro experiments to explore anti-pulmonary hypertension (PH) effect. In vitro, we induced malignant...
Diastereoselective methylation of dimethyl (S)-malate (8) followed by two three-step reductive dehydroxylation procedures afforded (R)-2-methylsuccinate (16) in 80.2% and 84.7% ee respectively, the later was further transformed into natural enantiomers ant venom alkaloids (R)-leptothoracine (1) (R)-3-methyl-N-(2-phenylethyl)pyrrolidine (2) (3R, 2'S)-3-methyl-N-(2-methylbutyl)pyrrolidine (3).Substituted pyrrolidine moiety is found a large number naturally occurring pyrrolidine, pyrrolizidine,...
Ethnopharmacological relevance: Asthma is a chronic airway inflammatory disease. Current treatment with mainstream medications has significant side effects. There growing evidence that the refractoriness of asthma closely related to common changes in lung and intestine. The lungs intestines, as sites frequent gas exchange body, are widely populated signaling molecules NO CO, which constitute NO-CO metabolism may be relevant pathogenesis intestines. Chinese herbal formula Tingli Dazao Xiefei...
Objective To explore the intervention mechanism of acacetin combined with wortmannin on myocardial fibrosis in fructose-induced SHR rats. Methods Using rats HUVEC cell induced by high-sugar DMEM, was explored. Results In rats, results showed that significantly downregulated serum REN, Ang II, ET-1 levels, and upregulated PGE2 NO levels ( P < 0.05 or 0.01). The combination further enhanced effect level 0.05). Acacetin increased expression CD31 protein CD31, VE-cadherin mRNA heart,...