Denize Atan
A5031321430- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Ocular Diseases and Behçet’s Syndrome
- Ophthalmology and Visual Impairment Studies
- Retinal and Optic Conditions
- Retinal Development and Disorders
- Cerebral Venous Sinus Thrombosis
- Corneal surgery and disorders
- Systemic Lupus Erythematosus Research
- Memory and Neural Mechanisms
- Inflammasome and immune disorders
- Multiple Sclerosis Research Studies
- Photoreceptor and optogenetics research
- Neurological Complications and Syndromes
- Genetic Associations and Epidemiology
- Diversity and Career in Medicine
- Child Nutrition and Feeding Issues
- COVID-19 and healthcare impacts
- Blood Pressure and Hypertension Studies
- Genetic and Kidney Cyst Diseases
- Ophthalmology and Eye Disorders
- Chronic Kidney Disease and Diabetes
- Membrane-based Ion Separation Techniques
- Pituitary Gland Disorders and Treatments
University of Bristol
2015-2025
Bristol Eye Hospital
2011-2025
University Hospitals Bristol NHS Foundation Trust
2019-2025
University Hospitals Bristol and Weston NHS Foundation Trust
2020-2025
UK Biobank
2021-2023
ORCID
2023
North Bristol NHS Trust
2020-2021
At Bristol
2021
University College London
2020
Moorfields Eye Hospital
2020
Abstract Medical artificial intelligence (AI) offers great potential for recognizing signs of health conditions in retinal images and expediting the diagnosis eye diseases systemic disorders 1 . However, development AI models requires substantial annotation are usually task-specific with limited generalizability to different clinical applications 2 Here, we present RETFound, a foundation model that learns generalizable representations from unlabelled provides basis label-efficient adaptation...
<h3>Abstract</h3> <h3>Objectives</h3> To determine whether more years spent in education is a causal risk factor for myopia, or myopia education. <h3>Design</h3> Bidirectional, two sample mendelian randomisation study. <h3>Setting</h3> Publically available genetic data from consortiums applied to large, independent population cohort. Genetic variants used as proxies and of were derived large genome wide association studies: 23andMe Social Science Association Consortium (SSGAC), respectively....
A guideline is proposed that comprises the minimum items to be reported in research studies involving an eye tracker and human or non-human primate participant(s). This was developed over a 3-year period using consensus-based process via open invitation international tracking community. will reviewed at maximum intervals of 4 years.
Cadaveric studies have shown disease-related neurodegeneration and other morphological abnormalities in the retina of individuals with Parkinson disease (PD); however, it remains unclear whether this can be reliably detected vivo imaging. We investigated inner retinal anatomy, measured using optical coherence tomography (OCT), prevalent PD subsequently assessed association these markers development a prospective research cohort.
Optical Coherence Tomography (OCT) enables non-invasive imaging of the retina and is used to diagnose manage ophthalmic diseases including glaucoma. We present first large-scale genome-wide association study inner retinal morphology using phenotypes derived from OCT images 31,434 UK Biobank participants. identify 46 loci associated with thickness nerve fibre layer or ganglion cell plexiform layer. Only one these has been glaucoma, despite its clear role as a biomarker for disease, Mendelian...
Serum lipids are modifiable, routinely collected blood test features associated with cardiovascular health. We examined the association of commonly serum lipid measures (total cholesterol [TC], high-density lipoprotein [HDL-C], low-density [LDL-C], and triglycerides) intraocular pressure (IOP).Cross-sectional study in UK Biobank European Prospective Investigation into Cancer Nutrition (EPIC)-Norfolk cohorts.We included 94 323 participants from (mean age, 57 years) 6230 EPIC-Norfolk 68...
Better understanding of primary open-angle glaucoma (POAG) genetics could enable timely screening and promote individualized disease risk prognostication.
Abstract Background Diabetes mellitus is a chronic disease which detrimental to cardiovascular health, often leading secondary microvascular complications, with huge global health implications. Therapeutic interventions that can be applied multiple vascular beds are urgently needed. Diabetic retinopathy (DR) and diabetic kidney (DKD) characterised by early permeability changes which, if left untreated, lead visual impairment renal failure, respectively. The heparan sulphate cleaving enzyme,...
Abstract Background Sensory changes due to aging or disease can impact brain tissue. This study aims investigate the link between glaucoma, a leading cause of blindness, and alterations in connections. Methods We analyzed diffusion MRI measurements white matter tissue large group, consisting 905 glaucoma patients (aged 49-80) 5292 healthy individuals 45-80) from UK Biobank. Confounds group differences were mitigated by matching sub-sample controls subjects. compared classification using...
Current methods to diagnose neurodegenerative diseases are costly and invasive. Retinal neuroanatomy may be a biomarker for more processes can quantified in vivo using optical coherence tomography (OCT), which is inexpensive noninvasive. We examined the association of neuroretinal morphology with brain MRI image-derived phenotypes (IDPs) large cohort healthy older people.UK Biobank participants aged 40 69 years old underwent comprehensive examinations including ophthalmic imaging...
To examine the associations of alcohol consumption with glaucoma and related traits, to assess whether a genetic predisposition modified these associations, perform Mendelian randomization (MR) experiments probe causal effects. Cross-sectional observational gene–environment interaction analyses in UK Biobank. Two-sample MR using summary statistics from large consortia. Biobank participants data on intraocular pressure (IOP) (n = 109 097), OCT-derived macular inner retinal layer thickness...
Strabismus refers to an abnormal alignment of the eyes leading loss central binocular vision. Concomitant strabismus occurs when angle deviation is constant in all positions gaze and often manifests early childhood it considered be a neurodevelopmental disorder visual system. As such, inherited as complex genetic trait, affecting 2–4% population. A genome-wide association study (GWAS) for self-reported (1345 cases 65,349 controls from UK Biobank) revealed single significant locus on...
Purpose: Cross-sectional and longitudinal studies have consistently reported an association between education myopia. However, conventional observational are at risk of bias due to confounding by factors such as socioeconomic position parental educational attainment. The current study aimed estimate the causal effect on refractive error using regression discontinuity analysis. Methods: Regression analysis was applied assess influence raising school leaving age (ROSLA) from 15 16 years...
The diagnosis of multiple sclerosis is based on a combination clinical and paraclinical tests. potential contribution retinal optical coherence tomography (OCT) has been recognized. We tested the feasibility OCT measures asymmetry as diagnostic test for at community level. In this community-based study 72 120 subjects, we examined inter-eye difference inner data using UK Biobank collected 22 sites between 2007 2010. reporting quality control guidelines were followed. percentage (IEPD)...
Abstract Few metrics exist to describe phenotypic diversity within ophthalmic imaging datasets, with researchers often using ethnicity as a surrogate marker for biological variability. We derived continuous, measured metric, the retinal pigment score (RPS), that quantifies degree of pigmentation from colour fundus photograph eye. RPS was validated two large epidemiological studies demographic and genetic data (UK Biobank EPIC-Norfolk Study) reproduced in Tanzanian, an Australian, Chinese...
Papilloedema can be the first sign of life-threatening disease, for example, brain tumours. Due to potential seriousness this clinical sign, detection papilloedema would normally prompt urgent hospital referral further investigation. The problem is that many benign structural variations optic nerve anatomy mistaken papilloedema, so-called pseudopapilloedema. consequence people are referred because they incorrectly identified have when don't. As a result, referrals with suspected in England...
Purpose To report the prevalence of visual acuity, field, and ocular motility problems in children with epilepsy referred to Children's Epilepsy Surgery Service (CESS) for surgery. Methods This was a retrospective observational study all CESS Bristol between 2015 2020. Data extraction included age, age at diagnosis, etiology (as determined by seizure semiology, neuroimaging, electroencephalography), anti-seizure drugs, motility, fundus imaging. Results A total 221 were seen during period:...
Noninfectious uveitis is a sight-threatening immune-mediated intraocular inflammatory disorder. The inheritance of in multiplex families and its association with known monogenic polygenic immunologic disorders suggests that common genetic variants underlie susceptibility to as well other disorders. TNFA IL10 are strong candidate genes, given the influence these cytokines on inflammation, immune tolerance, apoptosis.The role 12 polymorphisms spanning genomic regions was investigated 192...
The white-dot syndromes are a heterogenous group of chorioretinal disorders that have many common clinical features. Whether these represent distinct entities or different manifestations the same disease warrants further interrogation. Two were investigated, with closely overlapping phenotypes--multifocal choroiditis panuveitis (MFCPU) and punctate inner choroidopathy (PIC)--for differences in course genotype frequency at IL10 TNF loci, known to be associated noninfectious uveitis.Twelve...