A5081850154- Acute Ischemic Stroke Management
- Genetic Associations and Epidemiology
- Cerebrovascular and Carotid Artery Diseases
- Chronic Disease Management Strategies
- COVID-19 and healthcare impacts
- Intracerebral and Subarachnoid Hemorrhage Research
- COVID-19 Clinical Research Studies
- Cerebrovascular and genetic disorders
- Dementia and Cognitive Impairment Research
- Machine Learning in Healthcare
- Antiplatelet Therapy and Cardiovascular Diseases
- Biomedical Text Mining and Ontologies
- Health Systems, Economic Evaluations, Quality of Life
- Health disparities and outcomes
- Healthcare cost, quality, practices
- Venous Thromboembolism Diagnosis and Management
- Neurosurgical Procedures and Complications
- Glaucoma and retinal disorders
- Long-Term Effects of COVID-19
- Cancer-related molecular mechanisms research
- Retinal Diseases and Treatments
- Blood Pressure and Hypertension Studies
- Atrial Fibrillation Management and Outcomes
- Intracranial Aneurysms: Treatment and Complications
- Retinal Imaging and Analysis
University of Edinburgh
2016-2025
Health Data Research UK
2018-2025
British Heart Foundation
2020-2025
Genomics (United Kingdom)
2024
Edinburgh Cancer Research
2020-2024
UK Dementia Research Institute
2020-2024
Western General Hospital
2010-2024
University of Dundee
2024
National Institute for Health Research
2020-2023
University of Oxford
2002-2023
Cathie Sudlow and colleagues describe the UK Biobank, a large population-based prospective study, established to allow investigation of genetic non-genetic determinants diseases middle old age.
The UK Biobank cohort is a population-based of 500,000 participants recruited in the United Kingdom (UK) between 2006 and 2010. Approximately 9.2 million individuals aged 40-69 years who lived within 25 miles (40 km) one 22 assessment centers England, Wales, Scotland were invited to enter cohort, 5.5% participated baseline assessment. representativeness was investigated by comparing demographic characteristics nonresponders responders. Sociodemographic, physical, lifestyle, health-related...
Abstract Objective To develop and validate a pragmatic risk score to predict mortality in patients admitted hospital with coronavirus disease 2019 (covid-19). Design Prospective observational cohort study. Setting International Severe Acute Respiratory emerging Infections Consortium (ISARIC) World Health Organization (WHO) Clinical Characterisation Protocol UK (CCP-UK) study (performed by the ISARIC Coronavirus Consortium—ISARIC-4C) 260 hospitals across England, Scotland, Wales. Model...
Comparing stroke rates in different parts of the world may increase our understanding both etiology and prevention. However, comparisons are meaningful only if studies use standard definitions methods, with comparably presented data. We compared incidence its pathological types (cerebral infarction, primary intracerebral hemorrhage, subarachnoid hemorrhage) recent from around world.Studies a midyear 1984 or later, fulfilling criteria for comparable, community-based study, provided original...
Background and Purpose— The contribution of genetics to stroke risk, whether this differs for different subtypes, remainsuncertain. Genomewide complex trait analysis allows heritability be assessed from genomewide association study (GWAS) data. Previous candidate gene studies have identified many associations with stoke but these are important requires replication in large independent data sets. GWAS sets provide a powerful resource perform studies. Methods— We applied set 3752 ischemic...
Objectives UK Biobank is a UK-wide cohort of 502,655 people aged 40–69, recruited from National Health Service registrants between 2006–10, with healthcare data linkage. Type 2 diabetes key exposure and outcome. We developed algorithms to define prevalent incident for Biobank. The will be implemented by their results made available researchers on request. Methods used self-reported medical history medication assign type, tested this against linked primary secondary care in Welsh...
Causes of the well-documented association between low levels cognitive functioning and many adverse neuropsychiatric outcomes, poorer physical health earlier death remain unknown. We used linkage disequilibrium regression polygenic profile scoring to test for shared genetic aetiology functions disorders health. Using information provided by published genome-wide study consortia, we created scores 24 vascular–metabolic, neuropsychiatric, physiological–anthropometric traits in participants UK...
If the diagnostic and prognostic significance of brain microbleeds (BMBs) are to be investigated used for these purposes in clinical practice, observer variation BMB assessment must minimized.
Abstract Objective Lacunar stroke is common (25% of ischemic strokes) and mostly because an intrinsic cerebral microvascular disease unknown cause. Although considered primarily to be process, the vessel tissue damage could also explained by dysfunctional endothelium or blood–brain barrier (BBB) leak, not just ischemia. We tested for subtle generalized BBB leakiness in patients with lacunar control cortical stroke. Methods recruited mild assessed leak gray matter, white cerebrospinal fluid,...
Prospective, population-based studies that recruit participants in mid-life are valuable resources for dementia research. Follow-up these is often through linkage to routinely-collected healthcare datasets. We investigated the accuracy of datasets case ascertainment a validation study using data from UK Biobank—an open access, > 500,000 adults aged 40–69 years at recruitment 2006–2010. From 17,198 Biobank recruited Edinburgh, we identified those with ≥ 1 code their linked primary care,...
Background UK Biobank is a well-characterised cohort of over 500 000 participants including genetics, environmental data and imaging. An online mental health questionnaire was designed for to expand its potential. Aims Describe the development, implementation results this questionnaire. Method expert working group questionnaire, using established measures where possible, consulting patient group. Operational criteria were agreed defining likely disorder risk states, lifetime depression,...
Abstract Medical artificial intelligence (AI) offers great potential for recognizing signs of health conditions in retinal images and expediting the diagnosis eye diseases systemic disorders 1 . However, development AI models requires substantial annotation are usually task-specific with limited generalizability to different clinical applications 2 Here, we present RETFound, a foundation model that learns generalizable representations from unlabelled provides basis label-efficient adaptation...
Background UK Biobank is a well-characterised cohort of over 500 000 participants that offers unique opportunities to investigate multiple diseases and risk factors. Aims An online mental health questionnaire completed by was expected expand the potential for research into disorders. Method expert working group designed questionnaire, using established measures where possible, consulting with patient regarding acceptability. Case definitions were defined operational criteria lifetime...
Enlarged perivascular spaces (also known as Virchow-Robin spaces) on T2-weighted brain magnetic resonance imaging are common, but their etiology, and specificity to small vessel opposed general cerebrovascular disease or ageing, is unclear. We tested the association between enlarged ischemic stroke subtype, other markers of disease, common vascular risk factors.We prospectively recruited patients with acute stroke, diagnosed subtyped by a physician using clinical features imaging. A...
Abstract Objective To evaluate the associations of a polygenic risk score and healthy lifestyle with incident stroke. Design Prospective population based cohort study. Setting UK Biobank Study, UK. Participants 306 473 men women, aged 40-73 years, recruited between 2006 2010. Main outcome measure Hazard ratios for first stroke, estimated using Cox regression. A 90 single nucleotide polymorphisms previously associated stroke was constructed at P<1×10 −5 to test an association Adherence...